Natural Product Research,
Год журнала:
2025,
Номер
unknown, С. 1 - 8
Опубликована: Март 7, 2025
Multidrug-resistant
bacterial
species
and
their
untreatable
infections
threaten
human
health
worldwide.
The
four
seasons'
essential
oils
(EOs)
of
Operculicarya
decaryi
were
investigated
against
methicillin
resistant
Staphylococcus
aureus
MRSA.
Limonene
was
the
major
component
identified
in
O.
EOs
followed
by
methyl
cinnamate.
autumn
oil
(Odao)
has
a
robust
antibacterial
effect
Camphor,
carvone,
p-cymen-7-ol,
α-terpinen-7-al,
cryptone,
caryophyllene
oxide
highly
correlated
to
observed
activity.
Odao
exhibited
significant
wound
healing
ability
remarkable
anti-inflammatory
activity
adult
dermal
fibroblasts
(HDFa)
cells
inflammatory
model.
A
reduction
microbial
counts
recovered
from
spleens
groups
treated
either
Fusidic
acid
or
vivo
skin
infection
murine
model
observed.
This
study
is
first
record
for
phytochemical
composition
its
antimicrobial,
activities,
suggesting
camphor,
p-cymen-7-ol
as
top
components.
Pharmaceutics,
Год журнала:
2025,
Номер
17(4), С. 405 - 405
Опубликована: Март 24, 2025
Background:
Pseudomonas
aeruginosa
is
one
of
the
major
pathogens
that
cause
respiratory
infections.
The
rise
antimicrobial
resistance
has
prompted
a
need
for
alternatives
to
conventional
antibiotics.
Bacteriophages
(phages),
natural
predators
bacteria,
are
gaining
interest
as
an
alternative
therapeutic
option
against
drug-resistant
However,
phage
viability
can
be
lost
during
manufacturing
and
delivery.
Recent
studies
show
phages
taken
up
by
lung
epithelial
cells,
which
makes
fewer
available
antibacterial
action
extracellular
bacteria
P.
in
airways.
Methods:
In
this
study,
we
encapsulated
liposomes
using
thin
film
hydration.
effect
processing
conditions
loading
titer
on
encapsulation
was
studied.
impact
nebulization
tested
air-jet
nebulizer
(PARI-LC
Plus).
Phage
cellular
uptake
evaluated
vitro
H441
cell
model,
grown
at
air–liquid
interface.
Results:
Our
results
demonstrate
favorable
(58
±
6.02%)
achieved
with
minimum
loss
(0.64
0.21
log)
low
liposomal
formulations
exhibited
controlled
release
over
10
h.
formulation
also
reduced
from
1.55
0.04
log
(for
suspension)
1.08
0.05
liposomes).
Encapsulation
enabled
two-fold
reduction
longer
retention
human
monolayer.
Conclusions:
indicate
favors
protection
improves
availability
activity.
These
findings
highlight
potential
inhaled
Antibiotics,
Год журнала:
2024,
Номер
13(6), С. 561 - 561
Опубликована: Июнь 15, 2024
Klebsiella
pneumoniae
strains
that
are
resistant
to
multiple
drugs
(KPMDRs),
which
often
acquired
in
hospital
settings
and
lead
healthcare-associated
infections,
pose
a
serious
public
health
threat,
as
does
hypervirulent
K.
(hvKp),
can
also
cause
infections
otherwise
healthy
individuals.
The
widespread
unnecessary
use
of
antibiotics
seen
during
the
recent
COVID-19
pandemic
has
exacerbated
challenges
posed
by
antibiotic
resistance
clinical
settings.
There
is
growing
concern
(hvKp)
may
acquire
genes
confer
antimicrobial
resistance,
thus
combining
an
MDR
profile
with
their
increased
ability
spread
body
sites,
causing
difficult-to-treat
infections.
This
study
aimed
compare
virulence
profiles
KPC-3-producing
isolates
collected
over
four
years
(2020–2023).
A
genome-based
surveillance
all
CRE-K.
was
used
identify
genetic
differences
characterize
profiles.
Our
results
provide
picture
evolution
contribute
avoiding
possible
characteristics
multi-drug
virulence,
thought
be
one
main
global
health,
within
our
hospital.
Macromol—A Journal of Macromolecular Research,
Год журнала:
2025,
Номер
5(2), С. 15 - 15
Опубликована: Апрель 8, 2025
Antimicrobial
resistance
(AMR)
is
a
major
global
health
problem,
exacerbated
by
the
excessive
and
inappropriate
use
of
antibiotics
in
human
medicine,
animal
care
agriculture.
Therefore,
new
strategies
compounds
are
needed
to
overcome
this
issue.
In
view,
it
may
be
appropriate
reconsider
existing
biomaterials
alleviate
antibiotic
overuse.
Chitin,
naturally
abundant
amino
mucopolysaccharide,
poly-β-1,
4-N-acetylglucosamine
(GlcNAc).
It
white,
hard,
inelastic,
nitrogenous
polysaccharide
source
surface
pollution
coastal
areas.
Chitosan
derives
from
partial
N-deacetylation
chitin
originates
shells
crustaceans
fungi
cell
walls.
nontoxic
natural
antimicrobial
polymer
approved
GRAS
(Generally
Recognized
as
Safe
United
States
Food
Drug
Administration).
Chitin
chitosan,
non-toxic
biopolymers,
useful
for
wastewater
treatment
remove
pollutants,
such
pharmaceuticals,
heavy
metals
dyes.
The
described
features
make
these
biopolymers
intriguing
investigated
their
application
antibacterials.
Microbiology Spectrum,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 17, 2025
ABSTRACT
Antimicrobial
resistance
is
an
escalating
global
health
crisis,
underscoring
the
urgent
need
for
timely
and
targeted
therapies
to
ensure
effective
clinical
treatment.
We
developed
a
machine
learning
model
based
on
metagenomic
next-generation
sequencing
(mNGS)
rapid
antimicrobial
susceptibility
prediction
(mNGS-based
AST),
which
was
tailored
five
ESKAPEE
bacteria:
Acinetobacter
baumannii
,
Klebsiella
pneumoniae
Escherichia
coli
Pseudomonas
aeruginosa,
Staphylococcus
aureus
.
However,
utility
remained
unvalidated.
Assuming
that
mNGS-based
AST
results
were
obtained
during
management,
we
assessed
its
using
data
from
previous
observational
cohort
study
of
mNGS
applications.
collected
114
patients
infected
with
bacteria
07/2021
03/2023
incorporated
into
model.
evaluated
performance
hypothetical
impact
method
by
comparing
therapy
recommendations
those
traditional
culture-based
AST.
The
primary
outcome
(
n
=
113
strains).
displayed
overall
accuracy
93.84%
shorter
turnaround
time
(1.12
±
0.33
days
vs
2.81
0.57
AST,
t
−27.31,
P
<
0.05).
secondary
outcomes
included
proportion
who
could
benefit
It
allow
earlier
suitable
antibacterial
adjustments
in
32.05%
culture-positive
(25/78)
offer
actionable
16.67%
culture-negative
cases
(6/36).
offers
promising
approach
individualized
therapy.
IMPORTANCE
Metagenomic
(mNGS)-based
(AST)
novel
predicting
short-read
data.
it
significantly
reduce
while
maintaining
high
level
accuracy,
allowing
therapeutic
patients.
Furthermore,
can
be
integrated
maximize
without
substantial
cost
increases.
This
demonstrates
potential
precise,
selection
highlights
broader
applicability
enhancing
use
various
infections.
Heliyon,
Год журнала:
2024,
Номер
10(10), С. e31420 - e31420
Опубликована: Май 1, 2024
Schoepfia
schreberi
has
been
used
in
Mayan
folk
medicine
to
treat
diarrhea
and
cough.
This
study
aimed
determine
the
anti-growth,
anti-resistance,
anti-virulence
activities
of
S.
extracts
against
Acinetobacter
baumannii,
a
pathogen
leader
that
causes
healthcare-associated
infections
with
high
rates
drug-resistant
including
carbapenems,
last
line
antibiotics
known
as
superbugs,
analyze
their
composition
using
HPLC-DAD.
Ethyl
acetate
(SSB-3)
methanol
(SSB-4)
bark
exhibit
antimicrobial
biocidal
effects
drug-susceptible
A.
baumannii.
Chemical
analysis
revealed
SSB-3
SSB-4
contained
gallic
ellagic
acids
derivatives.
The
anti-resistance
activity
or
SSB-4,
combined
imipenem,
exhibited
potent
antibiotic
reversal
baumannii
by
acting
pump
efflux
modulators.
also
displayed
surface
motility
its
capacity
survive
reactive
oxygen
species.
suggests
can
be
considered
source
antibiotics,
even
adjuvanted
compounds,
anti-resistant
agents
contributing
ethnopharmacological
knowledge
reappraisal
medicinal
flora,
supporting
traditional
use
plant
for
treatment
infectious
diseases.
Antibiotics,
Год журнала:
2024,
Номер
13(12), С. 1219 - 1219
Опубликована: Дек. 14, 2024
Background:
The
COVID-19
pandemic
has
intensified
concerns
over
bacterial
infections
and
antimicrobial
resistance,
particularly
in
Romania.
This
systematic
review
explores
infection
patterns
resistance
during
the
to
address
critical
gaps
knowledge.
Methods:
A
review,
following
PRISMA
guidelines,
was
conducted
using
databases
such
as
PubMed
Scopus,
focusing
on
studies
of
from
2020
2022.
Articles
Romanian
patients
were
analyzed
for
demographic
data,
trends,
profiles.
Results:
total
87
included,
detailing
20,000
cases
infections.
found
that
Gram-negative
bacteria,
Escherichia
coli
Klebsiella
pneumoniae,
most
frequently
identified
pathogens,
alongside
Gram-positive
Staphylococcus
aureus
Enterococcus
spp.
Multidrug
(MDR)
noted
24%
reported
strains,
with
common
carbapenems
cephalosporins.
Conclusions:
amplified
complexity
managing
infections,
critically
ill
patients.
rise
MDR
bacteria
underscores
need
stringent
stewardship
control
measures.
Continuous
monitoring
trends
profiles
will
be
essential
improve
treatment
strategies
post-pandemic
healthcare
settings.
