From Entry to Outbreak in a High School Setting: Clinical and Wastewater Surveillance of a Rare SARS-CoV-2 Variant

Viruses, Год журнала: 2025, Номер 17(4), С. 477 - 477

Опубликована: Март 27, 2025

In December 2021, an outbreak of the SARS-CoV-2 B.1.640.2 variant, potentially originating from Cameroon, was investigated among schoolchildren in Germany. The index case, adult who had recently returned a three-week stay Republic Congo, introduced variant into school setting via their children, resulting subsequent transmission within and ultimately to hospital ward. Whole-genome sequencing viral samples identified both B.1.640.1 lineages. This highlights unpredictable nature emerging variants emphasizes importance early detection containment mitigate high-risk populations. Notably, wastewater surveillance detected during study peri-od, reinforcing utility wastewater-based epidemiology as complementary tool for warning novel variants. These findings underline critical need timely research adherence quarantine measures enhance control efforts.

Язык: Английский

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Wastewater Surveillance of SARS-CoV-2 in Zambia: An Early Warning Tool

Опубликована: Июнь 26, 2024

Wastewater-based surveillance has emerged as an important method for monitoring SARS-CoV-2. This study investigated the presence of SARS-CoV-2 in wastewater Zambia. We conducted a longitudinal Copperbelt and Eastern provinces Zambia from October 2023 to December during which 155 samples were collected. The subjected three different concentration methods, namely bag-mediated filtration, skimmed milk flocculation, polythene glycol-based assays. Molecular detection nucleic acid was using real-time PCR. Whole genome sequencing Illumina COVIDSEQ assay. Of samples, 62 (40%) tested positive these, 13 sequences sufficient length determine lineages obtained two phylogenetically analyzed. Various Omicron subvariants detected including BA.5, XBB.1.45, BA.2.86, JN.1. Some these have been clinical cases Interestingly, phylogenetic analysis positioned sequence Province B.1.1.529 clade, suggesting that earlier variants late 2021 could still be circulating may not wholly replaced by newer subvariants. stresses need integrating into mainstream strategies circulation

Язык: Английский

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Detection of Omicron variant in November 2021: a retrospective analysis through wastewater in Halifax, Canada

Environmental Science Water Research & Technology, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

This study evaluates the efficacy of wastewater surveillance and passive sampling techniques for early detection SARS-CoV-2 Omicron variant in a university setting Halifax, Canada.

Язык: Английский

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Wastewater Surveillance of SARS-CoV-2 in Zambia: An Early Warning Tool

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 8839 - 8839

Опубликована: Авг. 14, 2024

Wastewater-based surveillance has emerged as an important method for monitoring the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). This study investigated presence of SARS-CoV-2 in wastewater Zambia. We conducted a longitudinal Copperbelt and Eastern provinces Zambia from October 2023 to December during which 155 samples were collected. The subjected three different concentration methods, namely bag-mediated filtration, skimmed milk flocculation, polythene glycol-based assays. Molecular detection nucleic acid was using real-time Polymerase Chain Reaction (PCR). Whole genome sequencing Illumina COVIDSEQ assay. Of samples, 62 (40%) tested positive SARS-CoV-2. these, 13 sequences sufficient length determine lineages obtained phylogenetically analyzed. Various Omicron subvariants detected including BA.5, XBB.1.45, BA.2.86, JN.1. Some these have been clinical cases Interestingly, phylogenetic analysis positioned sequence Province B.1.1.529 clade, suggesting that earlier variants late 2021 could still be circulating may not wholly replaced by newer subvariants. stresses need integrating into mainstream strategies circulation

Язык: Английский

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Longitudinal safety and efficacy of the BNT162b2 mRNA COVID-19 vaccine in children aged 4–11 years with juvenile-onset autoimmune inflammatory rheumatic diseases: A prospective multicenter study

Vaccine, Год журнала: 2024, Номер 42(26), С. 126426 - 126426

Опубликована: Окт. 17, 2024

Язык: Английский

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Environmental Detection and Monitoring of SARS-CoV-2 for COVID-19 Risk Prediction

Springer eBooks, Год журнала: 2024, Номер unknown, С. 65 - 77

Опубликована: Янв. 1, 2024

Язык: Английский

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