Role of microRNAs in Immune Regulation with Translational and Clinical Applications
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(3), С. 1942 - 1942
Опубликована: Фев. 5, 2024
MicroRNAs
(miRNAs)
are
19-23
nucleotide
long,
evolutionarily
conserved
noncoding
RNA
molecules
that
regulate
gene
expression
at
the
post-transcriptional
level.
In
this
review,
involvement
of
miRNAs
is
summarized
in
differentiation
and
function
immune
cells,
anti-infective
responses,
immunodeficiencies
autoimmune
diseases.
Roles
anticancer
immunity
transplantation
solid
organs
hematopoietic
stem
cells
also
discussed.
Major
focus
put
on
translational
clinical
applications
miRNAs,
including
establishment
noninvasive
biomarkers
for
differential
diagnosis
prediction
prognosis.
Patient
selection
response
to
biological
therapy
one
most
promising
fields
application.
Replacement
or
inhibition
has
enormous
therapeutic
potential,
with
constantly
expanding
possibilities.
Although
important
challenges
still
await
solutions,
evaluation
miRNA
fingerprints
may
contribute
an
increasingly
personalized
management
dysregulation
a
remarkable
reduction
toxicity
treatment
side
effects.
More
detailed
knowledge
molecular
effects
physical
exercise
nutrition
system
facilitate
self-tailored
lifestyle
recommendations
advances
prevention.
Язык: Английский
Critical Role of Cellular microRNAs in Virus Infection: Decades of Progress
Animals and zoonoses.,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Interferon and immunity: the role of microRNA in viral evasion strategies
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Май 9, 2025
Interferons
(IFNs)
are
indispensable
innate
antiviral
cytokines
that
orchestrate
the
vertebrate
immune
response
against
viral
incursions.
Nearly
every
cell
possesses
remarkable
ability
to
release
IFNs
upon
detecting
threats,
triggering
a
robust
signaling
cascade
alerts
neighboring
cells
and
halts
propagation
via
paracrine
communication.
The
intricate
influence
of
is
mediated
by
an
extensive
network
proteins
activated
through
Jak-STAT
pathways,
facilitating
swift
transcription
over
300
interferon-stimulated
genes
(ISGs)
fortify
cellular
defenses
replication.
However,
cunning
nature
viruses
has
led
evolution
sophisticated
evasion
strategies,
notably
manipulation
host
microRNAs
(miRNAs)
disrupt
vital
components
IFN
machinery.
This
review
delves
into
interplay
between
infections
both
host-
viral-derived
miRNAs,
exploring
their
potent
roles
in
modulating
RIG-I-like
receptors,
Toll-like
JAK/STAT
pathway,
ultimately
shaping
landscape
immunity.
Язык: Английский
HIV-1 diagnostic, prognostic and ART-resistance detection potential of selected MiRNAs
BMC Infectious Diseases,
Год журнала:
2025,
Номер
25(1)
Опубликована: Июнь 2, 2025
The
global
HIV
prevalence
estimate
at
the
end
of
2022
was
39
million.
This
has
led
to
mass
testing
diagnose
new
cases,
and
conduction
prognostic
tests
for
monitoring
progression.
is
being
done
meet
targets
95%:
95%
UN
AIDS
goal
which
be
achieved
by
2025.
Therefore,
there
need
discover
other
diagnostic
biomarkers
supplemented
with
currently
used
ones.
Studies
indicate
that
micro
RNAs
have
their
levels
influenced
presence
replication
aetiologic
agents,
thus
RNA
(miRNA)
expression
profile
test
may
serve
dual
purpose
diagnosis
prognosis.
this
study
assessed
HIV-1
potential
patterns
circulating
miRNAs
in
positive
persons
Cape
Coast,
Ghana.
A
cross-sectional
research
design
assess
seven
-
hsa-mir-146a,
hsa-mir-155,
hsa-mir-34a,
hsa-mir-29a,
hsa-mir-29b,
hsa-mir-223
hsa-mir-27a
72
plasma
samples.
samples
were
obtained
from
six
antiretroviral
therapy
naïve
persons,
37
ART-experienced
29
healthy
controls.
Total
extracted,
afterwards,
cDNA
synthesis
RT-qPCR
done.
There
low
elevated
two
relative
control.
sensitivities
above
82.14%,
72.73%
81.25
respectively,
specificities
86.21%,
70.59%
87.50%
respectively.
Upregulated
associated
infection
ART-naïve
persons.
Hsa-mir-223,
hsa-mir-29a
hsa-mir29b
present
quantities
distinguished
between
viral
load
categories
classified
as
very
high.
These
correlated
load.
Low
hsa-mir-155
less
than
7cps/ml
them
HIV-negative
Increased
hsa-mir-146a
ART-resistance.
Decreased
could
HIV-1.
Hsa-mir-155,
good
progression
possess
detect
minute
copies.
Elevated
a
biomarker
Язык: Английский
Characterizing Host microRNA: Virus Interactions of Orthoavulavirus javaense
Viruses,
Год журнала:
2024,
Номер
16(11), С. 1748 - 1748
Опубликована: Ноя. 7, 2024
Post-transcriptional
gene
regulation
mediated
by
microRNAs
(miRNAs)
relies
on
sequence
complementarity
between
the
miRNA
seed
site
and
target
transcript(s).
This
can
completely
inhibit
or
reduce
translation
into
protein.
We
hypothesized
that
viruses
employ
complementarity/similarity
with
host
miRNAs
to
increase
miRNA-mediated
of
expression
specifically
during
viral
infection(s).
In
this
study,
we
focus
Язык: Английский
ПАТОГЕНЕТИЧНІ ОСОБЛИВОСТІ АНТИВІРУСНИХ БІЛКІВ ТА СИСТЕМИ CRISPR-CAS У ЛІКУВАННІ ХВОРИХ НА ВІЛ-ІНФЕКЦІЮ
Інфекційні хвороби,
Год журнала:
2024,
Номер
4, С. 64 - 72
Опубликована: Дек. 17, 2024
ВІЛ-інфекція
–
це
соціально
небезпечне
інфекційне
захворювання,
що
розвивається
внаслідок
довготривалого
персистування
вірусу
в
лімфоцитах,
макрофагах
і
клітинах
нервової
тканини.
Хвороба
характеризується
прогресуючою
дисфункцією
імунної,
нервової,
лімфатичної
та
інших
систем
організму.
Термінальною
стадією
є
синдром
набутого
імунного
дефіциту
(СНІД),
при
якому
імунна
система
організму
втрачає
можливість
захищати
хворого
від
ВІЛ-асоційованих
захворювань.
Без
лікування
смерть
СНІДу
настає
у
100
%
випадків.
Досі
немає
ефективних
вакцин
ліків
ВІЛ-інфекції.
Комбінована
антиретровірусна
терапія
(АРТ)
стандартом
лікування.
Основна
перешкода
лікуванні
хворих
на
ВІЛ-інфекцію,
тому
числі
АРТ,
наявність
резервуарів
ВІЛ,
які
можуть
активуватися
після
припинення
терапії.
Альтернативними
обнадійливими
методами
терапії
таких
редагування
генів
за
допомогою
білків
APOBEC3,
BST-2/Tetherin
системи
CRISPR-Cas.