Association of SARS-CoV-2 Seropositivity with Persistent Immune Activation in HIV/Tuberculosis Co-Infected Patients DOI Creative Commons
Ashwini Shete, Manisha Ghate, Hiroko Iwasaki

и другие.

Reports — Medical Cases Images and Videos, Год журнала: 2024, Номер 7(3), С. 61 - 61

Опубликована: Июль 29, 2024

We asked if SARS-CoV-2 seropositivity in HIV/TB co-infected patients plays a role precipitating active tuberculosis HIV-infected individuals and alters inflammatory status. A prospective study was conducted on presenting with pulmonary (n = 20) or extrapulmonary 12) tuberculosis. Abbott IgG kits assessed the presence of anti-nucleoprotein antibodies. Inflammatory markers viz. osteopontin, total full-length galectin-9, C-reactive protein were tested at baseline end antituberculosis treatment. The score (INS) based percentage reduction markers’ levels Anti-SARS-CoV-2 antibodies detected five male diagnosed 2) 3) TB. None them reported symptomatic COVID-19. marker did not differ significantly compared to those seronegative patients. However, INS correlated negatively (r −0.386, p 0.039), indicating persistently raised these treatment individuals. Among four studied, galectin-9 failed decrease (p 0.030). majority enrolled our (84.5%) SARS-CoV-2-seronegative, that infection might have played TB reactivation.

Язык: Английский

Association of SARS-CoV-2 Seropositivity with Persistent Immune Activation in HIV/Tuberculosis Co-Infected Patients DOI Creative Commons
Ashwini Shete, Manisha Ghate, Hiroko Iwasaki

и другие.

Reports — Medical Cases Images and Videos, Год журнала: 2024, Номер 7(3), С. 61 - 61

Опубликована: Июль 29, 2024

We asked if SARS-CoV-2 seropositivity in HIV/TB co-infected patients plays a role precipitating active tuberculosis HIV-infected individuals and alters inflammatory status. A prospective study was conducted on presenting with pulmonary (n = 20) or extrapulmonary 12) tuberculosis. Abbott IgG kits assessed the presence of anti-nucleoprotein antibodies. Inflammatory markers viz. osteopontin, total full-length galectin-9, C-reactive protein were tested at baseline end antituberculosis treatment. The score (INS) based percentage reduction markers’ levels Anti-SARS-CoV-2 antibodies detected five male diagnosed 2) 3) TB. None them reported symptomatic COVID-19. marker did not differ significantly compared to those seronegative patients. However, INS correlated negatively (r −0.386, p 0.039), indicating persistently raised these treatment individuals. Among four studied, galectin-9 failed decrease (p 0.030). majority enrolled our (84.5%) SARS-CoV-2-seronegative, that infection might have played TB reactivation.

Язык: Английский

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