Cells, Год журнала: 2024, Номер 13(18), С. 1512 - 1512
Опубликована: Сен. 10, 2024
The virus-host relationship is indispensable for executing successful viral infection. pathogenesis of HIV determined by an intricate interaction between the host and virus regulation infection, thereby influencing various aspects, including signaling pathways. High mutation rates population heterogeneity characterize with consequences potential to escape immune system anti-viral inhibitors used in therapy. origin high exhibited may be attributed a limited template-copied fidelity that likely operates cytoplasm. HIV-1 infection induces upregulation activation tumor suppressor p53 protein early stages plays multifaceted role context affecting replication. involved maintaining genetic integrity, actively participating DNA repair processes through its biochemical activities via ability interact components machinery. This report focuses on impact reverse transcription process while incorporating incorrect non-canonical nucleotides. presence functional host-coded proofreading-repair cytoplasm lead biological outcomes.
Язык: Английский