An exploration of the natural and acquired immunological mechanisms to high-risk human papillomavirus infection and unmasking immune escape in cervical cancer: A concise synopsis DOI Creative Commons

Mohammed Mohsen Mohammed,

Zaytoon A. Al-Khafaji,

Nadia Mudher Al-Hilli

и другие.

Tzu Chi Medical Journal, Год журнала: 2024, Номер 37(1), С. 28 - 41

Опубликована: Дек. 3, 2024

The most common STD that triggers cervical cancer is the human papillomavirus. More than 20 types of papillomavirus (HPV) can induce uterine cancer. Almost all women acquire genital HPV infection soon after their first intercourse, with them clearing virus within 3 years. An immune response necessary to clear. responders are innate system elements composed macrophages, keratinocytes, natural killer cells, and T-lymphocytic (NKT) cells. Cytotoxic T lymphocytes (CTLs) comprise second line defense kill HPV16-infected cells expressing various peptides derived from transforming early viral oncoproteins, mainly E2•E6. Even though manage trick away our systems, all, it important emphasize replication does not host It replicate antigens or cause inflammation. HPV16 E6 E7 genes suppress cell type 1 interferons (IFNs), which detectable infection. patient may have immunological tolerance; hence, there no costimulatory signals inflammatory cytokines like IFNs during antigen recognition. Evidence shows HlA class I generations been inhibited by E5, could protect this tumor CTL attack. responsible for initiating immunotolerance increasing regulatory (Treg) repress regression. Evasion protection plays a critical role in outcome persistent development Vaccination against 18 adolescence effective method preventing women, considering processes involved.

Язык: Английский

An exploration of the natural and acquired immunological mechanisms to high-risk human papillomavirus infection and unmasking immune escape in cervical cancer: A concise synopsis DOI Creative Commons

Mohammed Mohsen Mohammed,

Zaytoon A. Al-Khafaji,

Nadia Mudher Al-Hilli

и другие.

Tzu Chi Medical Journal, Год журнала: 2024, Номер 37(1), С. 28 - 41

Опубликована: Дек. 3, 2024

The most common STD that triggers cervical cancer is the human papillomavirus. More than 20 types of papillomavirus (HPV) can induce uterine cancer. Almost all women acquire genital HPV infection soon after their first intercourse, with them clearing virus within 3 years. An immune response necessary to clear. responders are innate system elements composed macrophages, keratinocytes, natural killer cells, and T-lymphocytic (NKT) cells. Cytotoxic T lymphocytes (CTLs) comprise second line defense kill HPV16-infected cells expressing various peptides derived from transforming early viral oncoproteins, mainly E2•E6. Even though manage trick away our systems, all, it important emphasize replication does not host It replicate antigens or cause inflammation. HPV16 E6 E7 genes suppress cell type 1 interferons (IFNs), which detectable infection. patient may have immunological tolerance; hence, there no costimulatory signals inflammatory cytokines like IFNs during antigen recognition. Evidence shows HlA class I generations been inhibited by E5, could protect this tumor CTL attack. responsible for initiating immunotolerance increasing regulatory (Treg) repress regression. Evasion protection plays a critical role in outcome persistent development Vaccination against 18 adolescence effective method preventing women, considering processes involved.

Язык: Английский

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