Current Situation of Goose Astrovirus in China: A Review

Viruses, Год журнала: 2025, Номер 17(1), С. 84 - 84

Опубликована: Янв. 10, 2025

Gosling gout disease is an infectious caused by goose astrovirus (GAstV), which can result in urate deposition the internal organs and joints of goslings. Since 2015, outbreaks gosling have occurred several goose-producing areas China. Subsequently, spread to vast majority eastern China, becoming a major threat farms causing huge economic losses industry. Meanwhile, GAstV infect species birds other than geese. It worth noting that, as emerging virus, research on still early stages. Therefore, investigation has become urgent issue, improve understanding develop effective measures control its poultry. The purpose this review summarize latest progress recent years, mainly focusing genetic evolution, pathogenesis, diagnostic detection, strategies GAstV, aiming provide reference for scientific prevention infection.

Язык: Английский

INTEGRATIVE TRANSCRIPTOMICS AND PROTEOMICS ANALYSIS PROVIDE A DEEP INSIGHT INTO GOOSE ASTROVIRUS-HOST INTERACTIONS DURING GASTV INFECTION

Poultry Science, Год журнала: 2024, Номер 103(12), С. 104287 - 104287

Опубликована: Сен. 3, 2024

Goose astrovirus (GAstV) is a newly discovered astrovirus. GAstV causes gout and death in 4- to -16-day-old goslings. For the past few years, fatal gout, cardinal clinical symptom of gosling infected with GAstV, has been spreading rapidly some goose Chinese farms, which caused continuous economic losses breeding industry China. Currently, several underlying mechanisms involved viral replication, inflammatory reaction, virions release, pathogenesis remain be elucidated. In this study, we explored GAstV-host interactions, transcriptome proteome profiles GAstV-infected LMH cells were sequenced by RNA-seq data-independent acquisition (DIA) techniques, respectively, followed using an integrative analysis. Compared uninfected cells, total 322 differentially expressed genes (DEG) (195 up-regulated, 127 down-regulated) 36 proteins (DEP) (31 5 detected. Nine DEGs randomly selected for further validation quantitative real-time polymerase chain reaction (qPCR). Through GO KEGG enrichment analysis, DEG DEP significantly enriched important cellular signaling pathways, including MAPK, PI3K-Akt, cAMP, chemokine, calcium, phospholipase D, Ras, TNF, IL-17, Rap1, NF-kappa B indicating that affects cell growth immune signaling. This study provided overview changes therefore, providing crucial basis explore interactions.

Язык: Английский

Digital PCR in Virology: Current Applications and Future Perspectives

Molecular Diagnosis & Therapy, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 2, 2024

Язык: Английский