Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106864 - 106864
Опубликована: Март 1, 2025
Язык: Английский
Nanoscale, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Gene and RNA-based therapeutics represent a promising frontier in oncology, enabling targeted modulation of tumor-associated genes proteins. This review explores the latest advances payload vectorization delivery systems developed for vivo cancer treatments. We discuss viral non-viral organic particles, including lipid based nanoparticles polymeric structures, effective transport plasmids, siRNA, self-amplifying RNA therapeutics. Their physicochemical properties, strategies to overcome intracellular barriers, innovations cell-based carriers engineered extracellular vesicles are highlighted. Moreover, we consider oncolytic viruses, novel capsid modifications, approaches that refine tumor targeting immunomodulation. Ongoing clinical trials regulatory frameworks guide future directions emphasize need safe, scalable production. The potential convergence these with combination therapies paves way toward personalized medicine.
Язык: Английский
Процитировано
1
Viruses, Год журнала: 2025, Номер 17(1), С. 86 - 86
Опубликована: Янв. 11, 2025
Recent decades have seen growing attention on viruses in the environment and their potential impacts as a result of global epidemics. Due to diversity viral species along with complexity environmental host factors, virus extraction detection methods become key for study ecology. This review systematically summarises extracting detecting pathogens from different samples (e.g., soil, water, faeces, air) biological plants, animals) existing studies, comparing similarities differences, applicability, well advantages disadvantages each method. Additionally, this discusses future directions research field. The aim is provide theoretical foundation technical reference ecology research, facilitating further exploration applications
Язык: Английский
Процитировано
0
Veterinary Microbiology, Год журнала: 2025, Номер 302, С. 110407 - 110407
Опубликована: Янв. 25, 2025
Язык: Английский
Процитировано
0
Molecules, Год журнала: 2025, Номер 30(4), С. 962 - 962
Опубликована: Фев. 19, 2025
Cardiovascular diseases (CVDs) represent a leading global health crisis, significantly impairing patients' quality of life and posing substantial risks to their survival. Conventional therapies for CVDs often grapple with challenges such as inadequate targeting precision, suboptimal therapeutic efficacy, potential adverse side effects. To address these shortcomings, researchers are intensively developing advanced drug delivery systems characterized by high specificity selectivity, excellent biodegradability, superior biocompatibility, minimal toxicity. These innovative enable the precise pharmaceuticals drug-loading capacities, leakage, expansive specific surface areas, thereby enhancing outcomes. In this review, we summarize classify various materials application values. We also evaluate feasibility efficacy viral non-viral vectors treatment CVDs, existing limitations prospects discussed. hope that review will provide new perspectives future development ultimately contributing improved patient care
Язык: Английский
Процитировано
0
Molecular Pharmaceutics, Год журнала: 2025, Номер unknown
Опубликована: Март 26, 2025
To understand requirements for immunization via the oral mucosa, an in vitro model that recapitulates physical barrier of mouth, allows quantification antigen uptake and permeability mounts inflammatory response to adjuvant is needed. The structure 4 models human mucosa was determined by histochemical staining transepithelial electrical resistance (TEER) measurements. A TR146 based air-liquid interface (ALI) most closely mimicked vivo conditions. This confirmed validation studies using dextran caffeine as diffusant molecules. Apparent coefficients (Papp) adenovirus (Ad) adeno-associated virus (AAV) this were 4.3 × 10-13 2.2 10-10 respectively, while 100% total dose H1N1 influenza remained epithelial layer. Sodium glycocholate a hyperosmotic formulation improved amount Ad (p = 0.02) AAV 0.003) entered epithelium, respectively. Significant amounts IL-6 (45.1 pg/mL), GM-CSF (94.7 pg/mL) IFN-γ (4.3 produced infection. Treatment with AS03-like induced production (34.9 TNF-∝ (43 (121.2 (14.1 pg/mL). highlights contribution differentiated cells immune vaccines adjuvants.
Язык: Английский
Процитировано
0
Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106864 - 106864
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0