Cyclophilin A Regulates Tripartite Motif 5 Alpha Restriction of HIV-1

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 495 - 495

Опубликована: Янв. 9, 2025

The peptidyl-prolyl isomerase A (PPIA), also known as cyclophilin (CYPA), is involved in multiple steps of the HIV-1 replication cycle. CYPA regulates restriction many host factors by interacting with CYPA-binding loop on capsid (CA) surface. TRIM5 (tripartite motif protein 5) primates a key species-specific factor defining pandemic. incomplete adaptation to humans due different utilization pandemic and non-pandemic HIV-1. enzymatic activity viral core likely an important reason for regulating activity. Thus, its interaction may serve new targets future anti-AIDS therapeutic agents. This article will describe species-specificity TRIM5, understand role retroviral infection, discuss research issues.

Язык: Английский

TRIM proteins: A ‘swiss army knife’ of antiviral immunity

PLoS Pathogens, Год журнала: 2025, Номер 21(5), С. e1013147 - e1013147

Опубликована: Май 12, 2025

With their modular structure and E3 ubiquitin ligase activity, Tripartite motif (TRIM) proteins interact with a wide range of cellular viral substrates. This review summarizes how they have emerged as key players in the antiviral response. Shortly, TRIM were shown (i) to enhance pro-inflammatory cytokines production by interacting pattern recognition receptors downstream components immune signaling pathways, (ii) interfere trafficking cytoskeleton, (iii) exhibit direct effects targeting for proteasomal degradation or inducing autophagy. combination actions underscores TRIMs potent innate defense system, but also makes them vulnerable evasion strategies.

Язык: Английский

Altered mitochondrial mass and low mitochondrial membrane potential of immune cells in patients with HBV infection and correlation with liver inflammation

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Ноя. 22, 2024

Mitochondrial membrane potential (MMP) and mitochondrial mass (MM) affect function lymphocyte activation, but few studies on HBV infection exist. This study aimed to investigate the regulatory mechanism of dysfunction during its clinical significance by analyzing alterations MM MMP

Язык: Английский