Effects of Herpesviruses on Proinflammatory Cytokines in Chronic Periapical Lesions DOI Creative Commons
Jelena Popović, Tatjana Cvetković, Tanja Džopalić

и другие.

Medical Science Monitor, Год журнала: 2024, Номер 31

Опубликована: Дек. 30, 2024

BACKGROUND Apical periodontitis is caused by infected dental pulp and may be associated with caries or trauma, which can destroy periradicular tissues. This study included periapical tissue of patients chronic apical aimed to evaluate the presence cytomegalovirus (CMV) Epstein-Barr virus (EBV) using polymerase chain reaction (PCR), determine levels inflammatory cytokines enzyme-linked immunoassay (ELISA). MATERIAL AND METHODS A total 79 participated in this study. Periapical lesions were taken from tooth roots indicated for extraction, divided into 2 groups: symptomatic asymptomatic. PCR was used identify HCMV EBV. Interleukin 6 (IL-6), interleukin 8 (IL-8), tumor necrosis factor-alpha (TNF-alpha), transforming growth factor beta-1 (TGFß-1) determined ELISA. RESULTS The occurrence (P<0.05) dual HCMV/EBV infection significantly more frequent compared concentrations IL-6, IL-8, TNF-alpha higher virus-positive virus-negative ones (P<0.05); especially high cytokine found (P<0.05). level TGF-ß1 lesions, but difference significant only CONCLUSIONS prevalence herpesviruses asymptomatic indicates their important role pathogenesis lesions. Expression TNF-alpha, IL-8 importance development clinical features herpesvirus-infected while appears no significance.

Язык: Английский

Analysis of factors influencing delayed treatment seeking for dental caries in preschool children: a cross-sectional study DOI Creative Commons
Ju Huang, Jiaqi Sun,

Ying Ji

и другие.

BMC Public Health, Год журнала: 2025, Номер 25(1)

Опубликована: Май 6, 2025

This study investigated the prevalence of treatment delays among preschoolers with dental caries, identified associated influencing factors, and predicted risk delayed treatment. The findings this provide an evidence base for future interventions designed to reduce in population. A convenience sample 264 preschool children caries their parents who visited paediatric department between October 2023 May 2024 was surveyed. Data were collected using a general information questionnaire, medical status Children's Fear Survey Schedule-Dental Subscale, Modified Version Dental Anxiety Scale, Short-Form Health Literacy Illness Perception Questionnaire Revised Dental. Influencing factors analysed univariate analysis binary logistic regression, whereas occurrence receiver operating characteristic (ROC) curve. 71.21%, average delay 117.5 days. Binary regression several independent significantly (P < 0.05), including primary caregiver, initial symptom recognition, children's fear, parental anxiety, oral health literacy. Predictive analyses indicated that fear (AUC: 0.765, 95%CI: 0.707-0.823) literacy 0.738, 0.673-0.802) demonstrated relatively high predictive values Efforts should prioritise addressing improving Targeted effective strategies these areas may facilitate early prevention, diagnosis, intervention, thereby minimising delays, reducing disease burden, promoting preschoolers.

Язык: Английский

Процитировано

0

Effects of Herpesviruses on Proinflammatory Cytokines in Chronic Periapical Lesions DOI Creative Commons
Jelena Popović, Tatjana Cvetković, Tanja Džopalić

и другие.

Medical Science Monitor, Год журнала: 2024, Номер 31

Опубликована: Дек. 30, 2024

BACKGROUND Apical periodontitis is caused by infected dental pulp and may be associated with caries or trauma, which can destroy periradicular tissues. This study included periapical tissue of patients chronic apical aimed to evaluate the presence cytomegalovirus (CMV) Epstein-Barr virus (EBV) using polymerase chain reaction (PCR), determine levels inflammatory cytokines enzyme-linked immunoassay (ELISA). MATERIAL AND METHODS A total 79 participated in this study. Periapical lesions were taken from tooth roots indicated for extraction, divided into 2 groups: symptomatic asymptomatic. PCR was used identify HCMV EBV. Interleukin 6 (IL-6), interleukin 8 (IL-8), tumor necrosis factor-alpha (TNF-alpha), transforming growth factor beta-1 (TGFß-1) determined ELISA. RESULTS The occurrence (P<0.05) dual HCMV/EBV infection significantly more frequent compared concentrations IL-6, IL-8, TNF-alpha higher virus-positive virus-negative ones (P<0.05); especially high cytokine found (P<0.05). level TGF-ß1 lesions, but difference significant only CONCLUSIONS prevalence herpesviruses asymptomatic indicates their important role pathogenesis lesions. Expression TNF-alpha, IL-8 importance development clinical features herpesvirus-infected while appears no significance.

Язык: Английский

Процитировано

0