Diagnostic Significance of Influenza Symptoms and Signs, and Their Variation by Type/Subtype, in Outpatients Aged ≥ 15 Years: Novi Sad, Serbia
Viruses,
Год журнала:
2025,
Номер
17(2), С. 272 - 272
Опубликована: Фев. 16, 2025
This
study
assessed
the
diagnostic
performance
of
influenza-related
symptoms
and
signs
their
combinations,
as
well
differences
in
patient
characteristics
based
on
type/subtype
influenza,
outpatients
at
a
primary
healthcare
surveillance
system.
Our
prospective
analysis
included
cases
aged
≥
15
years
from
two
influenza
seasons
(2022/23
2023/24)
Novi
Sad,
Serbia.
Influenza
were
confirmed
using
polymerase
chain
reaction
(PCR)
testing.
The
mean
age
participants
with
laboratory-confirmed
was
significantly
lower
than
that
those
without
(p
<
0.0001):
37.90
vs.
54.92
2022/23,
40.21
54.17
2023/24.
Among
examined
signs,
highest
sensitivity
2022/23
season
demonstrated
for
fever
(87.95%,
CI:
78.96-94.07),
while
2023/24
it
cough
(100.00%,
88.06-100.00).
In
season,
positive
predictive
values
(PPVs)
(34.93%),
chills
(31.95%),
myalgia
(30.30%),
malaise
(28.57%),
but
they
dropped
all
observed
(ranging
1.91%
to
9.17%).
Compared
World
Health
Organization's
case
definition
influenza-like
illness
(ILI),
provided
by
European
Centre
Disease
Prevention
Control
higher
specificity
across
both
seasons.
Participants
who
tested
between
December
February
more
likely
have
A(H1N1)pdm09
or
A(H3N2),
whereas
April
B.
underscores
importance
seasonal
timing,
symptom
evaluation,
definitions
improving
diagnosis
care.
Язык: Английский
Etiological Spectrum of Acute Respiratory Infections in Bulgaria During the 2023–2024 Season and Genetic Diversity of Circulating Influenza Viruses
Viruses,
Год журнала:
2025,
Номер
17(2), С. 270 - 270
Опубликована: Фев. 16, 2025
Influenza
poses
a
serious
threat
to
both
individual
and
public
health.
This
study
aimed
investigate
the
virological
epidemiological
characteristics
of
influenza
infections
explore
genetic
diversity
circulating
viruses.
In
total,
1886
nasopharyngeal
specimens
from
patients
with
acute
respiratory
illnesses
were
tested
against
13
viruses
using
multiplex
real-time
PCR.
Whole-genome
sequencing,
phylogenetic,
amino
acid
analyses
representative
strains
performed.
At
least
one
virus
was
detected
in
869
(46.1%)
patients;
87
(4.6%)
co-infected
two
or
three
A(H1N1)pdm09
most
prevalent
(16.1%),
followed
by
rhinoviruses
(8.1%)
RSV
(6.7%).
Hemagglutinin
(HA)
genes
74
categorized
subclades
C.1.8,
C.1.9,
C.1
within
clade
5a.2a
D1,
D.2,
D.3
5a.2a.1.
The
A(H3N2)
analyzed
belonged
2a.3a.1,
J.2
J.1.
sequenced
B/Victoria
lineage
fell
into
V1A.3a.2,
C.5.6
C.5.7.
Amino
substitutions
viral
proteins
identified
compared
vaccine
strains,
including
HA
antigenic
sites.
demonstrated
dominant
distribution
among
studied
Язык: Английский