Exploring the integration of nanotechnology in the development and application of biosensors for enhanced detection and monitoring of colorectal cancer

Inorganic Chemistry Communications, Год журнала: 2024, Номер 164, С. 112409 - 112409

Опубликована: Апрель 12, 2024

Язык: Английский

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Molecular mechanisms targeting drug-resistance and metastasis in colorectal cancer: Updates and beyond

World Journal of Gastroenterology, Год журнала: 2023, Номер 29(9), С. 1395 - 1426

Опубликована: Март 7, 2023

Colorectal cancer (CRC) is the third most diagnosed malignancy and a major leading cause of cancer-related deaths worldwide. Despite advances in therapeutic regimens, number patients presenting with metastatic CRC (mCRC) increasing due to resistance therapy, conferred by small population cells, known as stem cells. Targeted therapies have been highly successful prolonging overall survival mCRC. Agents are being developed target key molecules involved drug-resistance metastasis CRC, these include vascular endothelial growth factor, epidermal factor receptor, human receptor-2, mitogen-activated extracellular signal-regulated kinase, addition immune checkpoints. Currently, there several ongoing clinical trials newly targeted agents, which shown considerable efficacy improved prognosis who do not benefit from conventional chemotherapy. In this review, we highlight recent developments use existing novel agents against drug-resistant Furthermore, discuss limitations challenges associated therapy strategies combat intrinsic acquired therapies, importance implementing better preclinical models application personalized based on predictive biomarkers for treatment selection.

Язык: Английский

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Mechanisms of immune modulation in the tumor microenvironment and implications for targeted therapy

Frontiers in Oncology, Год журнала: 2023, Номер 13

Опубликована: Июнь 22, 2023

The efficacy of cancer therapies is limited to a great extent by immunosuppressive mechanisms within the tumor microenvironment (TME). Numerous immune escape have been identified. These include not only processes associated with tumor, or stromal cells, but also humoral, metabolic, genetic and epigenetic factors TME. identification has enabled development small molecules, nanomedicines, checkpoint inhibitors, adoptive cell that can reprogram TME shift host response towards promoting an antitumor effect. approaches translated into series breakthroughs in therapies, some which already implemented clinical practice. In present article authors provide overview most important immunosuppression implications for targeted against different cancers.

Язык: Английский

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NK Cell-Based Immunotherapy in Colorectal Cancer

Vaccines, Год журнала: 2022, Номер 10(7), С. 1033 - 1033

Опубликована: Июнь 28, 2022

Human Natural Killer (NK) cells are all round players in immunity thanks to their powerful and immediate response against transformed the ability modulate subsequent adaptive immune response. The potential of immunotherapies based on NK cell involvement has been initially revealed hematological setting but inspired design different tools also be applied solid tumors, including colorectal cancer (CRC). Indeed, despite prevention screening plans, surgery, chemotherapy strategies, CRC is one most widespread cancers with highest mortality rate. Therefore, further efficient complementary immune-based therapies urgent need. In this review, we gathered recent advances cell-based aimed at fighting CRC, particular, use monoclonal antibodies targeting tumor-associated antigens (TAAs), checkpoint blockade, adoptive therapy, modified chimeric antigen receptor (CAR-NK).

Язык: Английский

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Colorectal Cancer Chemoprevention: A Dream Coming True?

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(8), С. 7597 - 7597

Опубликована: Апрель 20, 2023

Colorectal cancer (CRC) is one of the deadliest forms worldwide. CRC development occurs mainly through adenoma-carcinoma sequence, which can last decades, giving opportunity for primary prevention and early detection. involves different approaches, ranging from fecal occult blood testing colonoscopy screening to chemoprevention. In this review, we discuss main findings gathered in field chemoprevention, focusing on target populations various precancerous lesions that be used as efficacy evaluation endpoints The ideal chemopreventive agent should well tolerated easy administer, with low side effects. Moreover, it readily available at a cost. These properties are crucial because these compounds meant long time risk profiles. Several agents have been investigated so far, some currently clinical practice. However, further investigation needed devise comprehensive effective chemoprevention strategy CRC.

Язык: Английский

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Inhibition of Human Colorectal Cancer by a Natural Product 7-Acetylhorminone and Interactions with BSA/HSA: Multispectral Analysis and In Silico and In Vitro Studies

ACS Applied Bio Materials, Год журнала: 2024, Номер 7(5), С. 3414 - 3430

Опубликована: Апрель 30, 2024

We have semi-synthesized a natural product 7-acetylhorminone from crude extract of Premna obtusifolia (Indian headache tree), which is active against colorectal cancer after probation through computational screening methods as it passed the set parameters pharmacokinetics (most important nonblood–brain barrier permeant) and drug likeliness (e.g., Lipinski's, Ghose's, Veber's rule) most other phytoconstituents failed to pass combined with docking EGFR protein highly upregulated in carcinoma cell. The structure was confirmed by single crystal X-ray diffraction studies 1H NMR, 13C COSY studies. To validate theoretical studies, first, vitro experiments were carried out human cell lines (HCT116) revealed potent cytotoxic efficacy verified preliminary investigation. Second, drugability interaction serum albumin proteins (HSA BSA) evaluated both theoretically experimentally via steady-state fluorescence spectroscopic circular dichroism, isothermal titration calorimetry, molecular docking. In summary, this study reveals applicability candidate or combinatorial cancer.

Язык: Английский

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Integrative multi-omics profiling of colorectal cancer from a Hispanic/Latino cohort of patients

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 4, 2024

ABSTRACT Colorectal cancer contributes to cancer-related deaths and health disparities in the Hispanic Latino community. To probe both biological genetic bases of disparities, we characterized features colorectal terms somatic alterations similarity. Specifically, conducted a comprehensive genome-scale analysis 67 samples. We performed DNA exome sequencing for mutations, copy number alterations, also RNA differential gene expression, cellular pathways, fusions. analyzed all samples 22 important CRC 8 amplifications, 25 Then, compared our data from publicly available, Non-Hispanic White (NHW) cohorts. According analyses, twenty-four percent carcinomas were hypermutated when patients Peruvians-from-Lima-like (1KG-PEL-like) similarity population 1000 genome project. Moreover, most these cases occurred who less than fifty years old age at diagnosis. Excluding tumors, approximately 55% colon cancers 58% rectum exhibited two similar features: 1) patterns genomic alterations; 2) percentage 1KG-PEL-like. -- which had median 1KG-PEL-like proportion One notable example frequently observed mutation was SMAD4. Samples with SMAD4 are known support tumor growth progression, highest (63%). results risk association analyses significant NHW Of drug-targetable PIK3CA PI3K an average over 55%. relevant fusions, targetable genes included ALK, FGFR1, RAF1, PTPRK; PTPRK sample (95%). Using integrative analysis, detected recurrent WNT, TGFB, TP53, IGF2/PI3K, RTK/RAS pathways. Importantly, mostly young high These findings highlight potential tailoring precision medicine therapeutics underrepresented population. Our study advances molecular profiling Hispanics Latinos. In toto, appears be component understanding carcinogenesis has advance research. Significance provides profiles underserved community, probes impact similarity, sheds light on disparities. This comprehensive, (CRCs) taken patients. general, cohort presented (55%) (24% cases) predominantly individuals Most (<50) assessed cross-referenced For example, frequent mutations suppressor called SMAD4; 63% PTPRK. 95% proportion. thus Latinos; suggests can tailored community; demonstrates carcinogenesis.

Язык: Английский

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Immune Checkpoint Inhibitor-Based Combination Therapy for Colorectal Cancer: An Overview

International Journal of General Medicine, Год журнала: 2023, Номер Volume 16, С. 1527 - 1540

Опубликована: Апрель 1, 2023

Colorectal cancer (CRC) is one of the most common diseases in world. Tumor immunotherapy an innovative treatment that acts by activating human body's autoimmune system. Immune checkpoint block has been shown to be effective DNA deficient mismatch repair/microsatellite instability-high CRC. However, therapeutic effect for proficient stability patients still requires further study and optimization. At present, main CRC strategy combine other methods, such as chemotherapy, targeted therapy, radiotherapy. Here, we review current status latest progress immune inhibitors same time, consider opportunities transforming cold hot, well perspectives on possible future therapies, which may great demand drug-resistant patients.

Язык: Английский

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Unveiling the genetic and epigenetic landscape of colorectal cancer: new insights into pathogenic pathways

Medical Oncology, Год журнала: 2023, Номер 40(11)

Опубликована: Окт. 19, 2023

Язык: Английский

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Beyond the Pill: How Nanorobots are Transforming Drug Delivery

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106817 - 106817

Опубликована: Март 1, 2025

Язык: Английский

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