Nanovaccines: A game changing approach in the fight against infectious diseases

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 167, С. 115597 - 115597

Опубликована: Сен. 30, 2023

The field of nanotechnology has revolutionised global attempts to prevent, treat, and eradicate infectious diseases in the foreseen future. Nanovaccines have proven be a valuable pawn this novel technology. are made up nanoparticles that associated with or prepared components can stimulate host's immune system. In addition their delivery capabilities, nanocarriers been demonstrated possess intrinsic adjuvant properties, working as cell stimulators. Thus, nanovaccines potential promote rapid well long-lasting humoral cellular immunity. several possible benefits, including site-specific antigen delivery, increased bioavailability, diminished adverse effect profile. To avail these nanoparticle-based vaccines being developed, virus-like particles, liposomes, polymeric nanoparticles, nanogels, lipid emulsion vaccines, exomes, inorganic nanoparticles. Inspired by distinctive researchers on development for variety applications, such cancer immunotherapy diseases. Although few challenges still need overcome, modulation nanoparticle pharmacokinetics avoid elimination from bloodstream reticuloendothelial system, future prospects technology also assuring, multiple options personalised needle-free formulations, combination promising candidates.

Язык: Английский

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Stability indicating ion-pair reversed-phase liquid chromatography method for modified mRNA

Journal of Pharmaceutical and Biomedical Analysis, Год журнала: 2024, Номер 245, С. 116144 - 116144

Опубликована: Апрель 10, 2024

Язык: Английский

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From private incentives to public health need: rethinking research and development for pandemic preparedness

The Lancet Global Health, Год журнала: 2023, Номер 11(10), С. e1658 - e1666

Опубликована: Авг. 28, 2023

Pandemic preparedness and response have relied primarily on market dynamics to drive development availability of new health products. Building calls for transformation, we propose a value proposition that instead prioritises equity from the research (R&D) stage strengthens capacity control outbreaks when where they occur. Key elements include regional R&D hubs free adapt well established technology platforms, independent clinical trials networks working with researchers, regulators, authorities better study questions comparative benefit real-world efficacy. Realising these changes requires shift in emphasis: pandemic outbreak control, one-size-fits-all economies scale manufacture local need, de novo product last-mile innovation through adaptation existing technologies, proprietary, competitive open science financing common good supports collective management sharing know-how.

Язык: Английский

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Artificial intelligence applications for fault detection and diagnosis in pharmaceutical bioprocesses: a review

Current Opinion in Chemical Engineering, Год журнала: 2024, Номер 44, С. 101025 - 101025

Опубликована: Май 11, 2024

Because of increasing demand and strict regulations, pharmaceutical manufacturers encounter significant hurdles in achieving high productivity while ensuring normal process states. Variability raw materials operational disturbances can lead to deviations from operating conditions that result decreased productivity. The implementation smart fault detection diagnosis (FDD) techniques is crucial for attaining acceptable safety. In this review, we identify the major challenges FDD processes, discuss future opportunities new perspectives.

Язык: Английский

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The Role of Therapeutic Vaccines in Cancer Immunotherapy

Onco, Год журнала: 2025, Номер 5(1), С. 11 - 11

Опубликована: Март 5, 2025

Cancer vaccines offer an exciting option for active immunotherapy, providing a potentially safe and effective treatment that also prevents or minimizes toxic side effects in vaccinated patients. Clinical results from previous phase III clinical trials have suggested the efficacy of cancer largely depends on their potential to trigger robust immunological responses. A preexisting immune response cancer-specific peptides is crucial achieving meaningful outcome during vaccinations. However, various factors may hinder effectiveness therapeutic vaccines. By overcoming these challenges, become cornerstone immunotherapy. This review aims share our insights major challenges are encountered when optimizing vaccines, particularly focusing important aspects regulating efficacy, such as vaccine composition, adjuvant be used HLA-restricting element tumor targeted by particular vaccine. Additionally, we discuss several obstacles which hindered successful development standard care, design, choice antigen(s) included formulation. The identification patients most likely respond vaccinations developing responses desirable crucial, and, therefore, predictive biomarkers strictly required. Finally, present views future prospects lead enhancement anticancer ensuring pivotal role

Язык: Английский

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Limit of Detection of Raman Spectroscopy Using Polystyrene Particles from 25 to 1000 nm in Aqueous Suspensions

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 14, 2025

Raman spectroscopy is an analytical method capable of detecting various microorganisms and small particles. Here, we used 25-1000 nm polystyrene particles in aqueous suspensions, which are comparable size to viral aggregates, determine the limit detection (LOD) a confocal microscope. We collected spectra using 785 wavelength laser with power 300 mW 10 s exposure time 5× objective lens. detected most prominent peak at 1001 cm-1, corresponding ring breathing mode. established minimum maximum LOD (LODmin LODmax) Kernel partial least-squares model. The smallest 50 was identified as 1.80 × 1012-8.31 1012 particle/mL, for largest 1000 nm, 5.11 108-2.53 109 particle/mL. demonstrated that nondestructive under these conditions by comparing particle before after collecting dynamic light scattering. Due their similarity this systematic characterization provides detailed information on spectral signatures suspensions. These findings establish foundation suspensions highlight its potential tool real-time monitoring vaccine manufacturing.

Язык: Английский

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Emerging and re-emerging pediatric viral diseases: a continuing global challenge

Pediatric Research, Год журнала: 2023, Номер 95(2), С. 480 - 487

Опубликована: Ноя. 8, 2023

Abstract The twenty-first century has been marked by a surge in viral epidemics and pandemics, highlighting the global health challenge posed emerging re-emerging pediatric diseases. This review article explores complex dynamics contributing to this challenge, including climate change, globalization, socio-economic interconnectedness, geopolitical tensions, vaccine hesitancy, misinformation, disparities access healthcare resources. Understanding interactions between environment, socioeconomics, is crucial for effectively addressing current future outbreaks. scoping focuses on infectious diseases, with an emphasis vulnerability. It highlights urgent need prevention, preparedness, response efforts, particularly resource-limited communities disproportionately affected change spillover events. Adopting One Health/Planetary Health approach, which integrates human, animal, ecosystem health, can enhance equity resilience communities. Impact We provide of threats populations provides update context COVID-19 pandemic aims sensitize clinicians, epidemiologists, public practitioners, policy stakeholders/decision-makers role these diseases have persistent morbidity mortality

Язык: Английский

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Unlocking cancer vaccine potential: What are the key factors?

Human Vaccines & Immunotherapeutics, Год журнала: 2024, Номер 20(1)

Опубликована: Апрель 2, 2024

Cancer is a global health challenge, with changing demographics and lifestyle factors producing an increasing burden worldwide. Screening advancements are enabling earlier diagnoses, but current cancer immunotherapies only induce remission in small proportion of patients come at high cost. vaccines may offer solution to these challenges, they have been mired by poor results past decades. Greater understanding tumor biology, coupled the success vaccine technologies during COVID-19 pandemic, has reinvigorated development. With first signs efficacy being reported, be beginning fulfill their potential. Solid tumors, however, present different hurdles than infectious diseases. Combining insights from previous clinical development contemporary knowledge immunology, we ask: who 'right' patients, what targets, which modalities maximize chances success?

Язык: Английский

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An mRNA technology transfer programme and economic sustainability in health care

Bulletin of the World Health Organization, Год журнала: 2024, Номер 102(5), С. 344 - 351

Опубликована: Май 1, 2024

The World Health Organization (WHO) set up the messenger ribonucleic acid (mRNA) technology transfer programme in June 2021 with a development hub South Africa and 15 partner vaccine producers middle-income countries.The goal was to support sustainable of access life-saving vaccines for people these countries as means enhance epidemic preparedness global public health.This initiative aims build resilience strengthen local research, manufacturing capacity different regions world, especially those areas that could not coronavirus disease 2019 (COVID-19) timely way.This paper outlines current market summarizes findings case study on mRNA conducted from November 2022 May 2023.The guided by vision WHO Council Economics All an economy health using its four work streams value, finance, innovation capacity.Based study, we offer mission-oriented policy framework pilot transformative change towards ecosystem common good.Parts this have already been incorporated into governance programme, while other aspects, good approach, still need be applied achieve goals programme.

Язык: Английский

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Genes, inflammatory response, tolerance, and resistance to virus infections in migratory birds, bats, and rodents

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Авг. 29, 2023

Normally, the host immunological response to viral infection is coordinated restore homeostasis and protect individual from possible tissue damage. The two major approaches are adopted by deal with pathogen: resistance or tolerance. nature of responses often differs between species individuals same species. Resistance includes innate adaptive immune control virus replication. Disease tolerance relies on allowing coexistence infections in minimal no clinical signs, while maintaining sufficient replication for transmission. Here, we compared virome bats, rodents migratory birds molecular mechanisms underlying symptomatic asymptomatic disease progression. We also explore influence physiology environmental influences RNA expression how it impacts whole brain transcriptome seemingly healthy semipalmated sandpiper ( Calidris pusilla ) spotted Actitis macularius ). Three time points throughout year were selected understand importance longitudinal surveys characterization virome. finally revisited evidence that upstream downstream regulation inflammatory is, respectively, associated infections.

Язык: Английский

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