The Immunogenicity of CpG, MF59-Like, and Alum Adjuvant Delta Strain Inactivated SARS-CoV-2 Vaccines in Mice DOI Creative Commons
Kangwei Xu, Jing Li,

Lu Xu

и другие.

Vaccines, Год журнала: 2024, Номер 12(1), С. 60 - 60

Опубликована: Янв. 7, 2024

The continuous evolution and mutation of SARS-CoV-2 have highlighted the need for more effective vaccines. In this study, CpG, MF59-like, Alum adjuvant Delta strain inactivated vaccines were prepared, immunogenicity these in mice was evaluated. + MF59-like vaccine group produced highest levels S- RBD-binding antibodies live virus neutralization after one shot immunization, while had two doses, groups high cross-neutralization against prototype, Beta, Gamma viruses. There no significant decrease neutralizing antibody any during observation period. excited different subtypes compared with unadjuvanted vaccines; CpG a higher proportion IgG2b antibodies, indicating bias towards Th1 immunity. proportions IgG1 similar to those vaccine. However, Th2 Antigen-specific cytokine secretion CD4/8+ T cells analyzed. conclusion, results study show differences immune efficacy mice, which implications selection strategy adjuvants.

Язык: Английский

The Immunogenicity of CpG, MF59-Like, and Alum Adjuvant Delta Strain Inactivated SARS-CoV-2 Vaccines in Mice DOI Creative Commons
Kangwei Xu, Jing Li,

Lu Xu

и другие.

Vaccines, Год журнала: 2024, Номер 12(1), С. 60 - 60

Опубликована: Янв. 7, 2024

The continuous evolution and mutation of SARS-CoV-2 have highlighted the need for more effective vaccines. In this study, CpG, MF59-like, Alum adjuvant Delta strain inactivated vaccines were prepared, immunogenicity these in mice was evaluated. + MF59-like vaccine group produced highest levels S- RBD-binding antibodies live virus neutralization after one shot immunization, while had two doses, groups high cross-neutralization against prototype, Beta, Gamma viruses. There no significant decrease neutralizing antibody any during observation period. excited different subtypes compared with unadjuvanted vaccines; CpG a higher proportion IgG2b antibodies, indicating bias towards Th1 immunity. proportions IgG1 similar to those vaccine. However, Th2 Antigen-specific cytokine secretion CD4/8+ T cells analyzed. conclusion, results study show differences immune efficacy mice, which implications selection strategy adjuvants.

Язык: Английский

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