SARS-CoV-2 Vaccine Improved Hemostasis of a Patient with Protein S Deficiency: A Case Report
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(19), С. 10717 - 10717
Опубликована: Окт. 5, 2024
A
16-year-old
patient,
while
an
infant,
incurred
right-sided
hemiparesis
and
had
difficulty
breast
feeding.
She
was
later
diagnosed
with
a
neonatal
stroke
her
genetic
testing
showed
missense
mutation
in
PROS1
(Protein
S)
gene.
Both
grandfather
father,
but
not
mother,
hereditary
Protein
S
(PS)
deficiency.
The
patient
prescribed
any
mediation
due
to
young
age
frequently
checked
by
physician.
patient’s
plasma
first
collected
at
the
of
13,
isolated
from
father
were
analyzed
aPTT,
thrombin
generation,
enzyme-linked
immunosorbent
assays.
These
analyses
low
PS
activity
clotting
time
associated
During
COVID-19
pandemic,
received
Pfizer
vaccination
dose
2021,
followed
booster
2022.
samples
8
weeks
post-immunization,
after
which
parameters
improved
for
up
6
months
following
vaccination.
significant
reduction
generation
aPTT
time.
Mass
spectrometry
analysis
revealed
that
antithrombin-III
level
significantly
higher
post-vaccination,
both
FXII
levels
lowered
compared
father.
To
our
knowledge,
this
is
report
document
can
lower
risk
thrombosis
inherited
thrombophilia.
Although
effect
observed
on
single
mutation,
it
would
be
interesting
investigate
vaccinations
other
Язык: Английский
Serum microRNA 143 and 223 Gene Expression Profiles as Potential Biomarkers in Individuals with Hepatitis and COVID-19
Viruses,
Год журнала:
2024,
Номер
16(11), С. 1734 - 1734
Опубликована: Ноя. 4, 2024
MicroRNAs
(miRNAs)
can
act
as
biomarkers
and
descriptors
of
the
association
between
infections
other
diseases,
such
hepatitis
COVID-19.
This
study
aims
to
investigate
role
miRNA
serum
expression
according
laboratory
data
concerning
Seventy
individuals
recruited
in
Southern
Southeastern
Brazil
donated
samples
were
divided
into
four
groups:
(i)
20
negative
subjects,
(ii)
presenting
hepatitis,
(iii)
19
with
COVID-19
(iv)
11
Three
miRNAs
(miR-122,
miR-143
miR-223)
evaluated
using
real-time
PCR.
Hematological
biochemical
markers
also
analyzed.
MiR-143
miR-223
downregulated
among
hepatitis/COVID-19
group
(p
<
0.05).
A
positive
correlation
was
observed
lymphocytes.
There
a
alanine
transaminase
(ALT)
aspartate
(AST)
for
gamma-glutamyl
transferase
(GGT),
alkaline
phosphatase
(AP)
neutrophil/lymphocyte
ratio
(NLR)
only
For
hepatic
fibrosis
(FIB-4),
miR-122
had
greater
more
associated
history
vaccination
against
143
223
could
be
useful
coinfection
Язык: Английский