Journal of Microbiology and Biotechnology, Год журнала: 2024, Номер 35
Опубликована: Ноя. 25, 2024
Язык: Английский
Food Chemistry Advances, Год журнала: 2025, Номер 6, С. 100919 - 100919
Опубликована: Фев. 11, 2025
Язык: Английский
Процитировано
4
Autoimmunity Reviews, Год журнала: 2025, Номер 24(5), С. 103775 - 103775
Опубликована: Фев. 13, 2025
Rheumatoid Arthritis (RA) is a persistent autoimmune inflammatory disorder that arises from the intricate interaction between genetic predisposition and environmental influences. The progression of RA can be delineated into four distinct phases: initially, influence risk factors; followed by emergence systemic autoimmunity; subsequently, an asymptomatic phase; ultimately, manifestation clinical arthritis. Recently, role mucosal immunity in has gained significant attention research. Evidence published studies suggests not only influences onset but also plays crucial its progression. Scholars have begun to unravel links barriers gastrointestinal tract, respiratory system, oral cavity. Specifically, shifts microbiota, dysfunction barriers, abnormal activation immune tissues are all implicated pathogenesis RA.Despite this growing body knowledge, comprehensive review therapeutic implications yet conducted. This emphasizes driving abnormalities development autoimmunity rheumatoid arthritis (RA). It further explores potential RA, as well issues challenges need addressed current research field, providing new perspective targets for prevention treatment RA.
Язык: Английский
Процитировано
1
Dentistry Journal, Год журнала: 2025, Номер 13(2), С. 79 - 79
Опубликована: Фев. 13, 2025
Background: Recent advances in mRNA vaccine technology, accelerated by the global COVID-19 pandemic, have generated significant interest their applications beyond infectious diseases. Dentistry has emerged as a promising field for exploring potential of mRNA-based therapies preventing and treating oral Objectives: This narrative review aims to evaluate current status development its preclinical health, focusing on periodontal disease, dental caries, regenerative medicine, implantology, cancer. Methods: The synthesizes findings from studies, including research conducted animal models vitro, assess modulate immune responses promote tissue regeneration cavity. Clinical trials were only mentioned context broader areas implementation such oncology immunotherapy. Results: studies highlight capacity vaccines enhance body's response facilitate repair processes. Despite these results, challenges persist delivering effectively within complex environment. These include stability, delivery mechanisms, modulation responses. Conclusions: While offer promise revolutionizing health care, they face notable limitations concerning safety, efficacy, clinical feasibility. Overcoming obstacles through further is essential unlock full translational ensure safe effective integration into practice.
Язык: Английский
Процитировано
1
Journal of Controlled Release, Год журнала: 2024, Номер 371, С. 179 - 192
Опубликована: Май 29, 2024
The delivery of vaccines plays a pivotal role in influencing the strength and longevity immune response controlling reactogenicity. Mucosal immunization, as compared to parenteral vaccination, could offer greater protection against respiratory infections while being less invasive. While oral vaccination has been presumed effective believed target mainly gastrointestinal tract, trans-buccal using mucoadhesive films (MAF) may allow targeted mucosa. Here we present an strategy for mucosal several vaccine platforms incorporated MAF, including DNA plasmids, viral vectors, lipid nanoparticles incorporating mRNA (mRNA/LNP). mRNA/LNP formulation targeting SARS-CoV-2 proof concept remained stable within MAF consisting slowly releasing water-soluble polymers impermeable backing layer, facilitating enhanced penetration into This elicited antibody cellular responses comparable intramuscular injection, but also induced production IgAs, highlighting its efficacy, particularly use booster potential advantage infections. preparation demonstrates significant advantages, such efficient delivery, stability, simple noninvasive administration with alleviate hesitancy.
Язык: Английский
Процитировано
5
Frontiers in Veterinary Science, Год журнала: 2025, Номер 11
Опубликована: Янв. 15, 2025
Trained immunity, characterized by long-term functional reprogramming of innate immune cells, offers promising new directions for veterinary vaccine development. This perspective examines how trained immunity can be integrated into design through metabolic and epigenetic modifications. We analyze key molecular mechanisms, including the shift to aerobic glycolysis sustained changes, that enable enhanced responses. Strategic approaches optimization are proposed, focusing on selecting effective inducers, developing innovative adjuvant systems, achieving synergistic enhancement While implementation challenges exist, individual response variations safety considerations, immunity-based vaccines show potential providing broader protection against emerging pathogens. approach could revolutionize vaccinology offering efficacy cross-protection heterologous infections, particularly valuable zoonotic disease control.
Язык: Английский
Процитировано
0
Analytical Biochemistry, Год журнала: 2025, Номер 700, С. 115787 - 115787
Опубликована: Янв. 31, 2025
Язык: Английский
Процитировано
0
Food Bioscience, Год журнала: 2025, Номер unknown, С. 106178 - 106178
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Cureus, Год журнала: 2025, Номер unknown
Опубликована: Март 15, 2025
Globally, periodontal diseases, mainly driven by polymicrobial biofilms, are a widespread concern of social medicine due to their considerable incidence and tie-up systemic disorders like diabetes, cardiovascular complications during pregnancy. Traditional treatments focus on mechanical debridement antimicrobial therapies, but these approaches have limitations, including recurrence antibiotic resistance. Periodontal vaccines offer promising alternative targeting the immunological mechanisms underlying disease. This review explores current state vaccine development, highlighting key antigens, delivery systems, preclinical clinical advancements. Special emphasis is placed antigen selection, host variability, immune tolerance, future directions overcome barriers. article highlights advancements challenges in research, offering insights into capability immunoprophylaxis as groundbreaking way manage diseases.
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Март 17, 2025
Respiratory syncytial virus (RSV) remains a significant global health concern, particularly for infants and young children in developing countries. Despite ongoing research efforts, an effective RSV vaccine has yet to be approved widespread use. Use of two separate pattern recognition receptor (PRR) agonists as adjuvants formulations shown enhance the immune response against antigen. The limitation with use is that they need not necessarily bind PRRs on same cell. This study evaluates efficacy different dual PRR binding chimeric molecules CL413 (TLR2/TLR7 agonist) CL429 (TLR2/NOD2 virus-like particles (VLPs) delivered via pulmonary route mice induction mucosal systemic immunity. BALB/c were immunized twice RSV-VLPs alone or adjuvanted CL413, CL429, mixture single Pam3CSK4+ L18-MDP imiquimod route. was used control adjuvants. Immune responses evaluated by measuring antibody levels sera respiratory tract; cytokine production, B T cell lungs spleen. Pulmonary immunization CL413-adjuvanted VLPs induced robust nasal IgA F G proteins, which observed other adjuvant combinations. also enhanced serum IgG promoted balanced Th1/Th2 response, evidenced IgG2a/IgG1 ratios. elicited strong pro-inflammatory mice, including elevated IFN-γ, TNF-α, IL-6, IL-17A. Flow cytometry analysis revealed increased numbers tissue-resident class-switched cells CL429. CD4+ CD8+ both spleens receiving various extents. Mice formalin inactivated (FI-RSV), are positive pathology after challenge developed alveolitis, perivascular infiltration. While all VLP showed protection lung challenge. lack pathology, combined responses, suggests delivery may provide without risk vaccine-enhanced disease. demonstrates TLR2/TLR7 agonist promising induce warrant further investigations more advanced preclinical models.
Язык: Английский
Процитировано
0
Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 111213 - 111213
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0