Magnetoencephalography Reveals Neuroprotective Effects of COVID-19 Vaccination in Non-Human Primates

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

COVID-19, caused by the SARS-CoV-2 virus, can lead to widespread neurological complications, including cognitive deficits and neurodegenerative symptoms, even in absence of significant structural brain abnormalities. The potential neuroprotective effects vaccination remain underexplored. Here, we demonstrate a psoralen-inactivated vaccine non-human primate model using resting-state magnetoencephalography (MEG), non-invasive neurophysiological recording technique with sub-millisecond temporal submillimeter spatial resolution. MEG scans demonstrated substantial preservation neural activity across multiple regions vaccinated subjects compared unvaccinated controls following viral challenge. This approach not only underscores role mitigating severe outcomes but also highlights capability detect subtle yet changes function that may be overlooked other imaging modalities. These findings advance our understanding vaccine-induced neuroprotection establish as powerful tool for monitoring context infections.

Язык: Английский

Enhanced sulfate pseudo-affinity chromatography using monolith-like particle architecture for purifying SARS-CoV-2

Vaccine, Год журнала: 2025, Номер 53, С. 126951 - 126951

Опубликована: Март 3, 2025

Язык: Английский