ALZHEIMER'S DISEASE: COMPREHENSIVE INSIGHTS INTO RISK FACTORS, BIOMARKERS, AND ADVANCED TREATMENT APPROACHES

International Journal of Current Pharmaceutical Research, Год журнала: 2025, Номер unknown, С. 1 - 10

Опубликована: Янв. 15, 2025

Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder primarily affecting individuals over 60. It multifactorial driven by both modifiable factors, such as lifestyle, diet, and prior health conditions, well non-modifiable like age, genetics, family history. The key pathological features of AD include the buildup amyloid β plaques neurofibrillary tangles resulting from hyperphosphorylated tau proteins in brain. Biomarkers protein levels cerebrospinal fluid (CSF) blood are essential for diagnosing tracking progression. Current research focuses on developing drugs targeting multiple aspects pathology, including inflammation, oxidative stress, synaptic dysfunction, accumulation. These treatments aim to slow cognitive decline neuronal damage. Given complexity AD, multi-targeted therapeutic approaches being explored enhance treatment efficacy. This review provides an overview risk biomarkers used diagnosis, latest advances clinical drug development.

Язык: Английский

Lipid nanoparticle (LNP) mediated mRNA delivery in neurodegenerative diseases

Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113641 - 113641

Опубликована: Март 1, 2025

Язык: Английский

Advances in Functional Organic-based Nanosystems for RNA Delivery, Targeting Different Organs

Materials chemistry horizons., Год журнала: 2024, Номер 3(2), С. 1 - 14

Опубликована: Ноя. 1, 2024

Язык: Английский