Group B streptococcal infections in pregnancy and early life DOI
Gygeria Manuel, Joy Twentyman, Kristen N. Noble

и другие.

Clinical Microbiology Reviews, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 25, 2024

SUMMARY Bacterial infections with Group B Streptococcus (GBS) are an important cause of adverse outcomes in pregnant individuals, neonates, and infants. GBS is a common commensal the genitourinary gastrointestinal tracts can be detected vagina approximately 20% women globally. infect fetus either during pregnancy or vaginal delivery resulting preterm birth, stillbirth, early-onset neonatal disease (EOD) first week life. The mother also become infected leading to postpartum endometritis, rarely, maternal sepsis. An invasive infection neonate may present after life (late-onset disease, LOD) through transmission from caregivers, breast milk, other sources. Invasive neonates result sepsis, pneumonia, meningitis, neurodevelopmental impairment, death, lifelong disability. A policy routine screening for rectovaginal colonization well-resourced countries trigger administration intrapartum antibiotic prophylaxis (IAP) when prenatal testing positive, which drastically reduces rates EOD. However, many do not routinely screen but administer IAP cases high risk does reduce LOD. global vaccination campaign needed significant burden that remains among infants individuals. In this narrative review, we provide comprehensive overview impact infection, virulence factors pathogenesis, current future prophylactics therapeutics.

Язык: Английский

Are We Making Progress with Perinatal and Neonatal Infections? DOI

Lucky Jain

Clinics in Perinatology, Год журнала: 2025, Номер 52(1), С. xv - xvii

Опубликована: Янв. 30, 2025

Язык: Английский

Процитировано

0
Maternal Vaccination and Neonatal Feeding Strategies Among Polish Women DOI Creative Commons
Jolanta Lis-Kuberka, Magdalena Orczyk‐Pawiłowicz

Vaccines, Год журнала: 2025, Номер 13(4), С. 376 - 376

Опубликована: Март 31, 2025

Background/Objectives: Maternal vaccination and breastfeeding are important aspects of public health that should be recommended by medical staff caring for pregnant postpartum women. We aimed to analyze factors affecting women’s likelihood dual during pregnancy their infant feeding strategies. Methods: A cross-sectional study was conducted with 953 Polish mothers. An online questionnaire used included questions on sociodemographic obstetric variables, attitudes towards COVID-19 influenza vaccination, practices. Results: reported 66.0%, 18.2%, 15.6% Increasing willingness receive vaccines significantly associated older maternal age, lower BMI, living in urban areas >100,000 residents, high levels knowledge regarding vaccination. No significant association between neonatal strategy detected. The group exclusively mothers, comparison formula- mixed-feeding women, characterized having pre-pregnancy BMI previous experience. Conclusions: Rates against seasonal (influenza COVID-19) remain low among promotion antenatal reliable information about short- long-term advantages related crucial perinatal care the mother–infant dyad. Young, primiparous women who overweight or obese targets preventive programs focused

Язык: Английский

Процитировано

0
Factors modulating maternofetal transfer of IgG antibodies following SARS-CoV-2 gestational infection DOI Creative Commons
Aline Almeida Bentes, Vívian Mara Gonçalves de Oliveira Azevedo, Stela Maris Aguiar Lemos

и другие.

Revista do Instituto de Medicina Tropical de São Paulo, Год журнала: 2025, Номер 67

Опубликована: Янв. 1, 2025

ABSTRACT Early infant immunity to SARS-CoV-2 depends on maternofetal transfer of antibodies. We aimed analyze the factors modulating anti-SARS-CoV-2 IgG antibodies following gestational infection during pandemic in Brazil (April–August 2021). conducted a retrospective and prospective cohort study involving 509 mother-child dyads tested simultaneously for anti-nucleocapsid universal neonatal screening. There were 341 seronegative 168 seropositive ones. Seropositive neonates retested two three months later. examined association serological status concentrations with mRNA vaccination, timing maternal infection, conditions, gender. Gestational predicted seropositivity (OR=3.97; 95%CI=2.69–5.88). Maternal first, second, or third trimester was associated progressively greater (34.4%, 51.6%, 58.2%, respectively; p=0.03). Among neonates, concentration higher when mothers reported they had COVID-19 pregnancy (p=0.04) tended be lower girls (p=0.06). More than half remained later (54.1%), which both at birth (p<0.001). Higher persistence anti-N more newborns. This provides an additional understanding dynamics antibody transfer.

Язык: Английский

Процитировано

0
Group B streptococcal infections in pregnancy and early life DOI
Gygeria Manuel, Joy Twentyman, Kristen N. Noble

и другие.

Clinical Microbiology Reviews, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 25, 2024

SUMMARY Bacterial infections with Group B Streptococcus (GBS) are an important cause of adverse outcomes in pregnant individuals, neonates, and infants. GBS is a common commensal the genitourinary gastrointestinal tracts can be detected vagina approximately 20% women globally. infect fetus either during pregnancy or vaginal delivery resulting preterm birth, stillbirth, early-onset neonatal disease (EOD) first week life. The mother also become infected leading to postpartum endometritis, rarely, maternal sepsis. An invasive infection neonate may present after life (late-onset disease, LOD) through transmission from caregivers, breast milk, other sources. Invasive neonates result sepsis, pneumonia, meningitis, neurodevelopmental impairment, death, lifelong disability. A policy routine screening for rectovaginal colonization well-resourced countries trigger administration intrapartum antibiotic prophylaxis (IAP) when prenatal testing positive, which drastically reduces rates EOD. However, many do not routinely screen but administer IAP cases high risk does reduce LOD. global vaccination campaign needed significant burden that remains among infants individuals. In this narrative review, we provide comprehensive overview impact infection, virulence factors pathogenesis, current future prophylactics therapeutics.

Язык: Английский

Процитировано

0