Altered microbiome and metabolome profiling in fearful companion dogs: An exploratory study

PLoS ONE, Год журнала: 2025, Номер 20(1), С. e0315374 - e0315374

Опубликована: Янв. 15, 2025

Behavioral dysfunctions in dogs represent one of the main social concerns, since they can endanger animals and human-dog relationship. Together with trigger stimulus (human, animal, place, scent, auditory stimuli, objects), experience stressful conditions, either multiple settings or unique situations, more often turning into generalized fear. Such a dysfunctional behavior be associated genetic susceptibility, environmental factors, traumatic experiences, medical conditions. The available therapy, based on approaches, management, neurochemical manipulation, through nutrition, supplements, medicines, pheromones, mainstays treatments currently accessible. Growing evidence humans highlight importance gut-brain axis modulation brain physiology as well. Here, taking advantage next generation sequencing approach, we sought to investigate potential connection between gut microbiota microbiome suffering from fear (n = 8), when compared healthy subjects who all lived different families. Faecal evaluation showed differential abundance taxa related Proteobacteria Firmicutes Phyla, case control dogs. Moreover, serum metabolomics documented significant alterations molecules GABA glutamate neurotransmission patients, well bile acids metabolism. Overall, our preliminary integrated investigations highlighted an intriguing role for microbiome-metabolome network, allowing further unveil pathophysiology relational issues companion paving way effective therapeutical approaches.

Язык: Английский

The use of anxiolytic drugs for the correction of behavioral disorders in mammals

Regulatory Mechanisms in Biosystems, Год журнала: 2024, Номер 15(1), С. 42 - 48

Опубликована: Янв. 11, 2024

The issue of stress and behavioral disorders are growing significantly in the contemporary word humans animals alike. Various drugs used to modify affected behavior, including psychotropic, anticonvulsant, antihistamines, hormones, analgesics, neuroleptics. Psychotropic prescribed for with disorders, signs anxiety or hypersensitivity. Improving methods diagnosing treating can enhance animal welfare optimize husbandry technology. Future research should be aimed at improving optimizing use psychotropic various species. main indication anxiolytic is associated wild domestic animals. When mammals their pharmacological properties, dependence action on route administration, age species animal, ability selectively affect central nervous system taken into account. most commonly treatment fluoxetine, amitriptyline, escitalopram, haloperidol, zuclopentixol azaperone. Fluoxetine an effective drug dogs psychological changes. An important component escitalopram's effect psychomotor influence, when animal's behavior changes due improved motor activity. Zuclopentixol has a wide range anxiolytic, sedative analgesic effects cloven-hoofed Amitriptyline along antidepressant local impact. Azaperone pronounced It widely as anti-stress agent overcome caused by weaning, regrouping veterinary manipulations. often control aggressive group housing, especially pig industry. surveyed this paper, direct action, able manifest additional physiological effects, which account developing protocols problems. Further targeted studies required assess

Язык: Английский

Single-dose 1cp-LSD administration for canine anxiety: a pilot study

Veterinary Research Communications, Год журнала: 2024, Номер unknown

Опубликована: Сен. 17, 2024

Язык: Английский