Review of intra‐articular 2.5% polyacrylamide hydrogel, a new concept in the management of osteoarthritis DOI
Aziz Tnibar

Equine Veterinary Education, Год журнала: 2024, Номер unknown

Опубликована: Дек. 26, 2024

Summary Recent observational and experimental trials have demonstrated that intra‐articular 2.5% injectable polyacrylamide hydrogel (2.5 iPAAG) is highly effective, lasting safe for the treatment of equine osteoarthritis (OA). Over last decade, 2.5 iPAAG has shown to be a potent promising drug in medication OA horses, as no other single medical such prolonged efficacy. Preliminary observations on mechanisms action support mechanical effect through integration into synovial membrane, an increase joint elasticity possibly reducing overall capsule stiffness, provision viscosupplementation which contributes protecting articular surfaces. Because inert biocompatible hydrogel, effects arthrocentesis cytology parameters been observed. Studies also suggest positive occur absence neurotoxicity or fibrosis, with low‐level macrophage‐driven foreign body response. The membrane long‐acting represent new concepts management OA.

Язык: Английский

Review of intra‐articular 2.5% polyacrylamide hydrogel, a new concept in the management of osteoarthritis DOI
Aziz Tnibar

Equine Veterinary Education, Год журнала: 2024, Номер unknown

Опубликована: Дек. 26, 2024

Summary Recent observational and experimental trials have demonstrated that intra‐articular 2.5% injectable polyacrylamide hydrogel (2.5 iPAAG) is highly effective, lasting safe for the treatment of equine osteoarthritis (OA). Over last decade, 2.5 iPAAG has shown to be a potent promising drug in medication OA horses, as no other single medical such prolonged efficacy. Preliminary observations on mechanisms action support mechanical effect through integration into synovial membrane, an increase joint elasticity possibly reducing overall capsule stiffness, provision viscosupplementation which contributes protecting articular surfaces. Because inert biocompatible hydrogel, effects arthrocentesis cytology parameters been observed. Studies also suggest positive occur absence neurotoxicity or fibrosis, with low‐level macrophage‐driven foreign body response. The membrane long‐acting represent new concepts management OA.

Язык: Английский

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