Clinical characteristics of COVID-19 associated vasculopathic diseases

Thrombosis Journal, Год журнала: 2023, Номер 21(1)

Опубликована: Май 25, 2023

Abstract Coronavirus disease 19 (COVID-19) has shown to be an infectious affecting not only of the respiratory system, but also cardiovascular system leading different COVID-19-associated vasculopathies. Venous and arterial thromboembolic events have been frequently described among hospitalized patients with COVID-19 inflammatory vasculopathic changes observed. Several reported associated vasculopathies exhibit differences on epidemiology, clinical characteristics outcome compared non-COVID-19 types. This review focuses clinical, diagnostic therapeutic as well data vasculopathies, elaborating similarities cohorts.

Язык: Английский

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Multifaceted Impact of the Coronavirus Disease 2019 (COVID-19) Pandemic on ST-Elevation Myocardial Infarction (STEMI): A Literature Review of Incidence, Treatment Modalities, and Outcomes

Cureus, Год журнала: 2024, Номер unknown

Опубликована: Март 30, 2024

The global repercussions of coronavirus disease 2019 (COVID-19) include substantial worldwide mortality and have brought to light existing gaps in healthcare systems. Particularly, diseases requiring time-sensitive treatment, such as ST-elevation myocardial infarction (STEMI), faced significant challenges due the impact revelations COVID-19 pandemic on infrastructure. This review addresses STEMI, exploring incidence, treatment modalities, clinical outcomes. Through a critical examination literature, intricate relationship between cardiovascular health, specifically is elucidated. has had management with changes hospitalization rates, strategies, presentation posing challenges. contradictory results post-vaccine infarction, well gender differences reported cases, highlight need for further research clarify these relationships.

Язык: Английский

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Heme catabolism and heme oxygenase-1-expressing myeloid cells in pathophysiology

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Окт. 24, 2024

Although the pathological significance of myeloid cell heterogeneity is still poorly understood, new evidence indicates that distinct macrophage subsets are characterized by specific metabolic programs influence disease onset and progression. Within this scenario, macrophages, endowed with high rates heme catabolism stress-responsive enzyme oxygenase-1 (HO-1), play critical roles in physiologic conditions. Of relevance, substrates HO-1 activity groups derive from cellular converted into carbon monoxide (CO), biliverdin Fe2+, which together elicit anti-apoptotic, anti-inflammatory activities control oxidative damage. While levels expression specialized populations (erythrophagocytes) guarantee physiological disposal senescent red blood cells (i.e. erythrocateresis), action takes on various diseases, abnormal CO metabolism has been observed cancer, hematological hypertension, heart failure, inflammation, sepsis, neurodegeneration. Modulation production therefore a feasible therapeutic opportunity diseases. In review we discuss role different contexts infections, cardiovascular, immune-mediated neurodegenerative diseases) highlight perspectives modulation enzymatic HO-1.

Язык: Английский

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Comparison of Angiographic and Clinical Outcomes After Primary Percutaneous Coronary Intervention for ST-elevation Myocardial Infarction Between Patients With and Without Concomitant COVID-19 Infection

Critical Pathways in Cardiology A Journal of Evidence-Based Medicine, Год журнала: 2022, Номер 21(3), С. 141 - 146

Опубликована: Июль 7, 2022

COVID-19 infection can involve the cardiovascular system and worsen prognosis of patients. This study aimed to investigate adverse effects on angiographic clinical outcomes primary percutaneous coronary intervention (PCI) in patients with acute ST-elevation MI compare results those without disease.The was a retrospective observational cohort, which presented from February 2020 April 2021, treated PCI were divided into 2 groups based infection. Then, procedural indices also compared between groups.A total 1150 enrolled study. Those established had worse baseline thrombolysis myocardial infarction flow grade at higher risk for such as lower frame count, blush grade, slow-flow disease, after PCI. Additionally, presence time related significantly duration hospitalization in-hospital mortality. Given potential impact other factors outcomes, analysis all endpoints done again adjustment these same before, suggesting independent effect infection.The concomitant undergoing is associated angiographic, outcomes. Surprisingly, this finding regardless patients' demographical characteristics.

Язык: Английский

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COVID-19 Infection and St-Elevation Myocardial Infarction: Lessons in Disease Management During a Pandemic

Cureus, Год журнала: 2024, Номер unknown

Опубликована: Июнь 9, 2024

The emergence of the SARS-CoV-2 virus, causing COVID-19 pandemic, has profoundly impacted global health, resulting in significant morbidity and mortality worldwide. This paper presents a case study highlighting heightened risk severe cardiovascular complications following infection. A 61-year-old male with hyperlipidemia was discharged after pneumonia treatment experienced ST-elevated myocardial infarction (STEMI) within day discharge. retrospective chart review, supplemented by literature revealed pattern increased severity STEMI cases associated COVID-19, particularly patients pre-existing comorbidities. induces prothrombotic state, which causes endothelial dysfunction systemic inflammation, potentially precipitating thrombotic events. Managing concurrent poses unique challenges, emphasizing critical role timely intervention, such as percutaneous coronary intervention (PCI), improving patient outcomes. Despite advancements, uncertainty persists regarding optimal thromboembolism prophylaxis post necessitating ongoing research meticulous clinical management. While infection rates have declined since this report hopes to emphasize need for continued awareness recognizing potential risks underscore further investigation into new viral strains develop future.

Язык: Английский

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In-hospital outcomes of ST elevation myocardial infarction in post-COVID-19 patients

Russian Journal of Cardiology, Год журнала: 2023, Номер 28(2), С. 5278 - 5278

Опубликована: Март 20, 2023

Aim. To study clinical and anamnestic data, as well inhospital outcomes in patients with ST elevation myocardial infarction (STEMI) prior coronavirus disease 2019 (COVID-19) compared previously uninfected STEMI patients. Material methods. This prospective included 181 treated for STEMI. The were divided into 2 groups, depending on the anti-SARS-CoV-2 IgG titer follows: main group 62 seropositive patients, while control — 119 seronegative without COVID-19. Anamnesis, paraclinical examination, including electrocardiography, echocardiography, coronary angiography, performed. Mortality incidence of complications at hospital stage analyzed. Results. mean age was 62,6±12,3 years. vast majority men (69,1% (n=125)). median time from onset COVID-19 manifestations to 60,00 [45,00; 83,00] days. According to, both groups comparable severity circulatory failure (p>0,05). Coronary angiography found that group, Thrombolysis In Myocardial Infarction (TIMI) score 0-1 infarct-related artery recorded much less frequently (62,9% (n=39) vs, 77,3% (n=92), p=0,0397). Patients demonstrated a lower concentration leukocytes (9,30*109/l [7,80; 11,40] vs 10,70*109/l [8,40; 14,00], p=0,0065), higher levels C-reactive protein (21,5 mg/L [9,1; 55,8] 10,2 [5,1; 20,5], p=0,0002) troponin I (9,6 ng/mL [2,2; 26,0] 7,6 11,5], p=0,0486). Lethal outcome 6,5% (n=4) cases 8,4% (n=10) (p=0,6409). Both terms (recurrent infarction, ventricular fibrillation, complete atrioventricular block, stroke, gastrointestinal bleeding) during hospitalization Conclusion. after COVID-19, despite more burdened history I, did not differ significantly status, morbidity, mortality.

Язык: Английский

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COVID-19 as an independent predictor of aspiration thrombectomy in STEMI. National data from the ORPKI register in the years 2020–2022

Advances in Interventional Cardiology, Год журнала: 2023, Номер 19(2), С. 119 - 126

Опубликована: Янв. 1, 2023

Coronavirus disease 2019 (COVID-19) exacerbates intravascular thrombosis that occurs in the coronary artery ST-elevation myocardial infarction (STEMI).To analyze impact of COVID-19 on application and effect thrombectomy STEMI patients.29915 patients were analyzed, whom 3139 (10.5%) underwent thrombectomy. (+) was reported 311 (10.8%). The clinical characteristics management (-) compared. A multivariable logistic regression analysis performed search factors influencing thrombectomy.COVID-19 had higher Killip class (IV class; n = 33 (12.31%) vs. 138 (5.84%); p < 0.0001) cardiac arrest at baseline more frequent this group (n 25 (8.04%) 137 (4.84%); 0.016). Thrombolysis (TIMI) 3 after percutaneous intervention less 248 (80.52%) 2388 (87.19%); 0.001) group. Periprocedural mortality similar both groups 28 (0.99%) 4 (1.29%); 0.622). In increased risk (OR 1.23; 97.5% CI: 1.05-1.43; 0.001).STEMI undergoing aspiration who likely to be a severe condition (higher class, before procedure) than patients. Despite intensive antiplatelet anticoagulant treatment, PCI procedures result an optimal TIMI effect. is independent strong predictor patient qualification for STEMI.

Язык: Английский

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Pathological Interplay and Clinical Complications between COVID-19 and Cardiovascular Diseases: An Overview in 2023

Cardiology, Год журнала: 2023, Номер 149(1), С. 60 - 70

Опубликована: Авг. 16, 2023

The coronavirus disease 2019 (COVID-19) involves all organs of the body, which interaction with cardiovascular diseases is most important.

Язык: Английский

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Differences in door-to-balloon time and outcomes in SARS-CoV-2-positive ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention: A systematic review and meta-analysis

Medicine, Год журнала: 2023, Номер 102(41), С. e35612 - e35612

Опубликована: Окт. 13, 2023

Background: The coronavirus disease 2019 infection has significantly impacted the world and placed a heavy strain on medical system public, especially those with cardiovascular diseases. Hoverer, differences in door-to-balloon time outcomes ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention after severe acute respiratory syndrome 2 (SARS-CoV-2) are not known too much. Methods: Web of Science, EMBASE, PubMed, Cochrane Library, Wanfang, VIP, China’s National Knowledge Infrastructure were utilized to perform systematic literature search until April 30, 2023. We computed odds ratios (ORs) their corresponding 95% confidence intervals (CIs) determine correlation. A random-effects model was used for meta-analysis if study had significant heterogeneity. Meanwhile, sensitivity analysis Trial sequential also accomplished using Rveman5.4 trial 0.9.5.10 Beta software, respectively. Results: total 5 eligible studies explored our meta-analysis, including 307 cases 1804 controls. By pooled data showed that SARS-CoV-2-positive STEMI longer (OR 6.31, CI 0.99, 11.63, P = .02) than negative subjects. glycoprotein IIb/IIIa inhibitor use SARS-CoV-2 2.71, 1.53, 4.81, .0006) relatively frequent compared controls, postoperative Thrombolysis Myocardial Infarction blood flow 0.48, 0.34, 0.67, < .0001) worse that. in-hospital mortality 5.16, 3.53, 7.53, .00001) higher non-SARS-CoV-2 ones. In addition, we discovered age, gender (male), hypertension, diabetes mellitus, hyperlipidemia, smoking, previous infarction, ischemia time, thrombus aspiration did have association development SARS-CoV-2. Conclusion: positivity is associated intervention.

Язык: Английский

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An Analysis of STEMI Cases in the Postgraduate Hospital in Khost, Afghanistan

Journal for Research in Applied Sciences and Biotechnology, Год журнала: 2024, Номер 3(3), С. 165 - 169

Опубликована: Июль 8, 2024

Myocardial infarction, specifically ST elevation myocardial infarction (STEMI), involves the development of localized ischemic necrosis in heart muscle due to an acute disruption coronary blood flow. It clinically presents as burning, pressing, or squeezing chest pain that radiates left arm, collarbone, scapula, jaw, along with symptoms such shortness breath, a feeling fear, and cold sweat. Immediate hospitalization cardiac intensive care unit is crucial for patients developed delays treatment can be fatal. This study descriptive case series conducted year 1397 Islamic calendar. Out 1602 inpatients admitted Khost Postgraduate Hospital during this period, 50 were diagnosed STEMI. The primary objectives research determine frequency pattern STEMI cases at 1396

Язык: Английский

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