Bioengineering,
Год журнала:
2024,
Номер
11(5), С. 464 - 464
Опубликована: Май 7, 2024
Given
its
detrimental
effect
on
the
brain,
alcoholism
is
a
severe
disorder
that
can
produce
variety
of
cognitive,
emotional,
and
behavioral
issues.
Alcoholism
typically
diagnosed
using
CAGE
assessment
approach,
which
has
drawbacks
such
as
being
lengthy,
prone
to
mistakes,
biased.
To
overcome
these
issues,
this
paper
introduces
novel
paradigm
for
identifying
by
employing
electroencephalogram
(EEG)
signals.
The
proposed
framework
divided
into
various
steps.
begin,
interference
artifacts
in
EEG
data
are
removed
multiscale
principal
component
analysis
procedure.
This
cleaning
procedure
contributes
information
quality
improvement.
Second,
an
innovative
graphical
technique
based
fast
fractional
Fourier
transform
coefficients
devised
visualize
chaotic
character
complexities
elucidates
properties
regular
alcoholic
Third,
thirty-four
features
extracted
interpret
signals'
haphazard
behavior
differentiate
between
trends.
Fourth,
we
propose
ensembled
feature
selection
method
obtaining
effective
reliable
group.
Following
that,
study
many
neural
network
classifiers
choose
optimal
classifier
building
efficient
framework.
experimental
findings
show
suggested
obtains
best
classification
performance
recurrent
(RNN),
with
97.5%
accuracy,
96.7%
sensitivity,
98.3%
specificity
sixteen
selected
features.
aid
physicians,
businesses,
product
designers
develop
real-time
system.
CNS Neuroscience & Therapeutics,
Год журнала:
2024,
Номер
30(5)
Опубликована: Май 1, 2024
Parkinson's
disease
(PD)
is
a
degenerative
neurological
condition
marked
by
the
gradual
loss
of
dopaminergic
neurons
in
substantia
nigra
pars
compacta.
The
precise
etiology
PD
remains
unclear,
but
emerging
evidence
suggests
significant
role
for
disrupted
autophagy-a
crucial
cellular
process
maintaining
protein
and
organelle
integrity.
A
single
rotary-valve
assisted
paper-based
immunoassay
device
(RAPID)
for
early
screening
of
Alzheimer's
disease
(AD),
enables
fully
automated
and
efficient
detection
the
AD
biomarker.
Life,
Год журнала:
2024,
Номер
14(3), С. 391 - 391
Опубликована: Март 15, 2024
Phase-amplitude
coupling
(PAC)
describes
the
interaction
of
two
separate
frequencies
in
which
lower
frequency
phase
acts
as
a
carrier
higher
amplitude.
It
is
means
carrying
integrated
streams
information
between
micro-
and
macroscale
systems
brain,
allowing
for
coordinated
activity
brain
regions.
A
beta-gamma
PAC
increase
over
sensorimotor
cortex
has
been
observed
consistently
people
with
Parkinson's
disease
(PD).
Its
cause
attributed
to
neural
entrainment
basal
ganglia,
caused
by
pathological
degeneration
characteristic
PD.
Disruptions
this
phenomenon
PD
patients
have
resting
state
well
during
movement
recordings
reliably
distinguished
from
healthy
participants.
The
changes
can
be
detected
non-invasively
electroencephalogram
(EEG).
They
correspond
severity
motor
symptoms
medication
status
Furthermore,
medication-induced
decrease
correlates
alleviation
measured
assessment
scales.
has,
therefore,
explored
possible
quantifying
pathology
application
parameter
closed-loop
deep
stimulation
could
serve
self-adaptation
measure
such
treatment,
responding
fluctuations
symptom
phase-dependent
provides
new
precise
method
modulating
increases
cortex.
This
review
offers
comprehensive
synthesis
current
EEG-based
evidence
on
PD,
explores
potential
practical
utility
biomarker,
recommendations
future
research.
Reviews in Medical Virology,
Год журнала:
2024,
Номер
34(4)
Опубликована: Июнь 11, 2024
The
Varicella-zoster
virus
(VZV),
classified
as
a
neurotropic
member
of
the
Herpesviridae
family,
exhibits
characteristic
pathogenicity,
predominantly
inducing
varicella,
commonly
known
chickenpox,
during
initial
infectious
phase,
and
triggering
reactivation
herpes
zoster,
more
recognized
shingles,
following
its
emergence
from
latent
state.
pathogenesis
VZV-associated
neuroinflammation
involves
complex
interplay
between
viral
replication
within
sensory
ganglia
immune-mediated
responses
that
contribute
to
tissue
damage
dysfunction.
Upon
primary
infection,
VZV
gains
access
ganglia,
establishing
infection
neurons.
During
reactivation,
can
spread
along
nerves,
cascade
inflammatory
mediators,
chemokines,
immune
cell
infiltration
in
affected
neural
tissues.
role
both
adaptive
innate
reactions,
including
contributions
T
B
cells,
macrophages,
dendritic
orchestrating
central
nervous
system
is
elucidated.
Furthermore,
aberrant
activation
natural
defence
mechanism,
characterised
by
dysregulated
production
immunomodulatory
proteins
has
been
implicated
VZV-induced
neurological
disorders,
such
encephalitis,
myelitis,
vasculopathy.
intricate
balance
protective
detrimental
context
emphasises
necessity
for
an
exhaustive
comprehension
immunopathogenic
mechanisms
propelling
neuroinflammatory
processes.
Despite
availability
vaccines
antiviral
therapies,
VZV-related
complications
remain
significant
concern,
particularly
immunocompromised
individuals
elderly.
Elucidating
these
might
facilitate
innovative
strategies
targeted
therapies
aimed
at
mitigating
improving
clinical
outcomes.
This
comprehensive
understanding
enhances
our
grasp
holds
promise
pioneering
therapeutic
designed
mitigate
ramifications
infections.
Abstract
In
this
investigation,
the
fractional
Hirota–Satsuma
coupled
Korteweg–de
Vries
(KdV)
problem
is
solved
using
two
modern
semi-analytic
techniques
known
as
Aboodh
residual
power
series
method
(ARPSM)
and
transform
iteration
(ATIM).
The
suggested
approaches
are
briefly
explained,
along
with
how
to
use
them
solve
KdV
problem.
Some
analytical
approximate
solutions
for
current
derived
proposed
until
second-order
approximation.
To
ensure
high
accuracy
of
approximation,
they
analyzed
numerically
graphically
compared
exact
integer
cases.
offered
demonstrate
more
in
their
outcomes
other
alternatives.
numerical
results
show
that
ARPSM
ATIM
highly
accurate,
practical,
beneficial
solving
nonlinear
equation
systems.
expected
help
many
physics
researchers
modeling
different
physical
problems,
especially
those
interested
plasma
physics.
Brain stimulation,
Год журнала:
2024,
Номер
17(3), С. 501 - 509
Опубликована: Апрель 17, 2024
BackgroundGait
impairment
has
a
major
impact
on
quality
of
life
in
patients
with
Parkinson's
disease
(PD).
It
is
believed
that
basal
ganglia
oscillatory
activity
at
β
frequencies
(15-30
Hz)
may
contribute
to
gait
impairment,
but
the
precise
dynamics
this
during
remain
unclear.
Additionally,
auditory
cues
are
known
lead
improvements
kinematics
PD.
If
neurophysiological
mechanisms
cueing
effect
were
better
understood
they
could
be
leveraged
treat
impairments
using
adaptive
Deep
Brain
Stimulation
(aDBS)
technologies.ObjectiveWe
aimed
characterize
subthalamic
nucleus
(STN)
stepping
movements
PD
and
establish
by
which
modulate
gait.MethodsWe
studied
STN
local
field
potentials
(LFPs)
eight
while
performed
movements.
Hidden
Markov
Models
(HMMs)
used
discover
transient
states
spectral
occurred
without
cues.ResultsThe
occurrence
low
high
bursts
was
suppressed
after
cues.
This
manifested
as
decrease
their
fractional
occupancy
state
lifetimes.
Interestingly,
α
transients
showed
opposite
effect,
lifetimes
increasing
cues.ConclusionsWe
show
frequency
bands
differentially
modulated
gait-promoting
These
findings
suggest
enhancement
rhythms
an
approach
for
ameliorating
