Review of the Applications of Micro/Nanorobots in Biomedicine
ACS Applied Nano Materials,
Год журнала:
2024,
Номер
7(15), С. 17151 - 17192
Опубликована: Июль 24, 2024
The
advancement
of
precision
medicine
in
modern
biomedicine
has
been
significantly
propelled
by
the
emergence
micro/nanorobots.
combination
micro/nanorobots
and
offers
unique
advantages
holds
attractive
potential
for
applications.
It
effectively
addresses
challenges
encountered
traditional
robots
areas
such
as
driving,
sensing,
intelligence
other
aspects,
especially
application
cancer
cardiovascular
diseases,
which
is
a
hot
field
interdisciplinary
research
recent
years.
This
review
succinctly
delineates
analyzes
advancements
First,
achievements
years
are
systematically
classified
introduced
from
four
perspectives:
manufacturing
design,
drive
control,
biomedical
degradation.
In
particular,
in-depth
discussions
were
conducted
regarding
solutions
each
stage.
Second,
based
on
latest
results
applications,
development
direction
industrial
applications
key
technical
aspects
that
need
to
be
paid
attention
emphasized.
Finally,
we
discuss
opportunities
future,
it
expected
will
become
more
sophisticated
capable
performing
multiple
medical
functions
tasks.
They
implemented
vivo
assist
doctors
diagnosing
treating
diseases.
shows
significant
medicine.
Язык: Английский
A Vascularized Multilayer Chip Reveals Shear Stress Induced Angiogenesis in Diverse Fluid Conditions
Cyborg and Bionic Systems,
Год журнала:
2025,
Номер
6
Опубликована: Янв. 1, 2025
Tissues
larger
than
400
μm
in
size
lacking
microvascular
networks
cannot
survive
for
long
periods
of
time
vitro.
The
development
microfluidic
technology
provides
an
efficient
research
tool
constructing
models
However,
traditional
single-layer
chips
faced
the
limitation
spatial
layout
and
could
not
provide
diverse
fluidic
environments
within
a
single
chip.
In
this
paper,
we
present
novel
chip
design
with
3-layer
configuration
that
utilizes
polycarbonate
(PC)
porous
membrane
to
separate
culture
fluid
channels
from
tissue
chambers,
featuring
flexibly
designable
multitissue
chambers.
PC
membranes
act
as
capillary
vertical
direction,
enabling
precise
hydrogel
patterning
successfully
environment
suitable
growth.
demonstrates
ability
build
different
shapes
such
triangle,
rectangle,
inverted
triangle
on
more
10
days.
cultured
12
days
were
perfused
70-kDa
fluorescein
isothiocyanate,
which
indicated
generated
had
good
barrier
properties.
A
correlation
between
chamber
shape
shear
stress
was
demonstrated
using
COMSOL,
preliminary
validation
flow
direction
interstitial
important
effect
growth
by
vascularization
experiments.
This
flexible
scalable
is
ideal
culturing
multiple
vascularized
organ
tissues
chip,
well
studying
effects
factors
Язык: Английский
Recent Advances and Future Perspectives in Vascular Organoids and Vessel-on-Chip
Gowtham Reddy Cheruku,
Chloe Veronica Wilson,
Suriya Raviendran
и другие.
Organoids,
Год журнала:
2024,
Номер
3(3), С. 203 - 246
Опубликована: Сен. 4, 2024
Recent
advancements
in
vascular
organoid
(VO)
and
vessel-on-chip
(VoC)
technologies
have
revolutionized
our
approach
to
studying
human
diseases,
offering
unprecedented
insights
through
more
physiologically
relevant
models.
VOs
generated
from
pluripotent
stem
cells
exhibit
remarkable
self-organization
capabilities,
forming
complex
three-dimensional
structures
that
closely
mimic
blood
vessel
architecture
function,
while
VoCs
are
engineered
with
microfluidic
systems
meticulously
recreate
the
physical
functional
attributes
of
vessels.
These
innovative
constructs
serve
as
powerful
tools
for
investigating
development,
disease
progression,
therapeutic
efficacy.
By
enabling
creation
patient-specific
VoCs,
they
pave
way
personalized
medicine
approaches,
allowing
researchers
delve
into
genetic
variations,
intricate
cellular
interactions,
dynamic
processes
exceptional
resolution.
The
synergy
between
newly
developed
cutting-edge
has
further
amplified
their
potential,
unveiling
novel
mechanisms
underlying
pathologies
identifying
promising
targets.
Herein,
we
summarize
different
types
present
an
extensive
overview
on
generation
applications
VoCs.
We
will
also
highlight
clinical
translational
challenges
future
perspectives
around
Язык: Английский
Advancing tissue engineering through vascularized cell spheroids: building blocks of the future
Biomaterials Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
This
review
provides
a
comprehensive
overview
of
vascularized
cell
spheroids,
highlighting
recent
advancements
in
biofabrication,
key
strategies
for
engineering
vascular
networks,
and
their
applications
tissue
models
regenerative
medicine.
Язык: Английский
Developments and Applications of Liver-on-a-Chip Technology—Current Status and Future Prospects
Biomedicines,
Год журнала:
2025,
Номер
13(6), С. 1272 - 1272
Опубликована: Май 22, 2025
Background/Objectives:
Liver-on-a-chip
(LiOC)
technology
is
increasingly
recognized
as
a
transformative
platform
for
modeling
liver
biology,
disease
mechanisms,
drug
metabolism,
and
toxicity
screening.
Traditional
two-dimensional
(2D)
in
vitro
models
lack
the
complexity
needed
to
replicate
liver’s
unique
microenvironment.
This
review
aims
summarize
recent
advancements
LiOC
systems,
emphasizing
their
potential
biomedical
research
translational
applications.
Methods:
narrative
synthesizes
findings
from
key
studies
on
development
application
of
platforms.
We
explored
innovations
material
science
bioengineering,
including
microfluidic
design,
3D
printing,
stem
cell–
tissue-derived
organoid
integration,
co-culture
strategies.
Commercially
available
systems
regulatory
relevance
were
also
evaluated.
Results:
have
evolved
simple
PDMS-based
chips
complex,
multicellular
constructs
incorporating
hepatocytes,
endothelial
cells,
Kupffer
hepatic
stellate
cells.
Recent
demonstrate
superior
ability
liver-specific
architecture
functions.
Applications
span
cancer
research,
assessment
(e.g.,
drug-induced
injury
prediction
with
>85%
sensitivity),
modeling,
regenerative
medicine.
Several
platforms
gained
FDA
recognition
are
active
use
preclinical
testing.
Conclusions:
offers
more
physiologically
relevant
alternative
traditional
holds
promise
reducing
reliance
animal
studies.
While
challenges
remain,
such
vascularization
long-term
function,
ongoing
paving
way
toward
clinical
pharmaceutical
integration.
The
poised
play
role
personalized
medicine
next-generation
therapeutic
development.
Язык: Английский
Engineering Cardiobundles with Dynamic Microenvironmental Control as Advanced Cardiac Modeling for Heart‐on‐a‐Chip
Small,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 26, 2025
Abstract
Advancing
cardioprotective
therapies
requires
physiologically
relevant
preclinical
models,
yet
conventional
approaches—including
2D
cell
cultures,
3D
spheroids,
and
animal
models—fail
to
fully
recapitulate
the
structural
complexity
dynamic
microenvironment
of
native
cardiac
tissue,
often
facing
species‐specific
discrepancies
ethical
concerns.
Organ‐on‐a‐chip
(OoC)
technology,
a
microfluidic‐based
biomimetic
system,
offers
real‐time
organ‐level
physiology
disease
progression
monitoring.
In
this
study,
heart‐on‐a‐chip
(HoC)
platform
is
developed
by
integrating
cardiobundles—engineered
tissues—with
microfluidic
technology.
Using
fibrinogen‐Matrigel
hydrogel
aligned
cardiobundles
are
fabricated
that
mimic
myocardial
architecture
function.
The
HoC
system
demonstrates
enhanced
cardiomyocyte
differentiation,
intercellular
connectivity,
calcium
handling,
contractility.
Furthermore,
effects
oxygen
nutrient
circulation,
as
well
microenvironmental
conditions,
systematically
assessed
on
cardiobundle
performance,
highlighting
platform's
physiological
relevance.
This
represents
promising
tool
for
drug
screening,
modeling,
personalised
medicine,
offering
alternative
traditional
models
in
research.
Язык: Английский
Light-Based 3D Bioprinting Techniques for Illuminating the Advances of Vascular Tissue Engineering
Materials Today Bio,
Год журнала:
2024,
Номер
29, С. 101286 - 101286
Опубликована: Окт. 2, 2024
Vascular
tissue
engineering
faces
significant
challenges
in
creating
Язык: Английский
Recent Advances and Future Perspectives in Vascular Organoids and Vessel-on-Chip
Gowtham Reddy Cheruku,
Chloe Veronica Wilson,
Suriya Raviendran
и другие.
Опубликована: Июль 14, 2024
Recent
advancements
in
vascular
organoid
(VO)
and
vessel-on-chip
(VoC)
technologies
have
revolutionized
our
approach
to
studying
cardiovascular
diseases
(CVDs),
offering
unprecedented
insights
through
more
physiologically
relevant
models.
VOs
generated
from
human
pluripotent
stem
cells
exhibit
remarkable
self-organization
capabilities,
forming
complex
three-dimensional
structures
that
closely
mimic
blood
vessel
architecture
function,
while
VoCs
engineered
with
groundbreaking
microfluidic
systems
meticulously
recreate
the
physical
functional
attributes
of
vessels.
These
innovative
constructs
serve
as
powerful
tools
for
investigating
development,
disease
progression,
therapeutic
efficacy.
By
enabling
creation
patient-specific
VoCs,
they
pave
way
personalized
medicine
approaches,
allowing
researchers
delve
into
genetic
variations,
intricate
cellular
interactions,
dynamic
processes
exceptional
resolution.
The
synergy
between
cutting-edge
such
single-cell
sequencing
high-resolution
imaging
has
further
amplified
their
potential,
unveiling
novel
mechanisms
underlying
CVDs
identifying
promising
targets.
Herein,
we
summarize
different
types
present
an
extensive
overview
on
generation
applications
CVDs.
We
will
also
highlight
clinical
translational
challenges
future
perspectives
around
VoCs.
Язык: Английский
Arched Microfluidic Channel for the Promotion of Axonal Growth Performance
iScience,
Год журнала:
2024,
Номер
27(10), С. 110885 - 110885
Опубликована: Сен. 4, 2024
Uniformly
distributed
fluid
shear
stress
can
promote
axonal
growth,
aiding
in
the
efficient
construction
of
functional
neural
interfaces.
However,
challenges
remain
micro-scale
environment
with
a
uniform
fluidic
distribution.
In
this
study,
we
designed
and
fabricated
microfluidic
chip
arched-section
channels
(AMCs)
to
increase
primary
cortical
neuron
growth
rate
terminal
number
by
constructing
uniform-stress-distributed
environment.
Inspired
three-dimensional
(3D)
microenvironment
where
cerebrospinal-fluid-contacting
neurons
are
located,
surface
curvature
traditional
rectangular-section
channel
(RMC)
was
adjusted
construct
structures
3D
curved
surfaces.
Compared
those
on
RMC
chips,
average
axons
AMC
chips
increased
8.9%
within
19
days,
terminals
14.9%.
This
platform
provides
structure
that
effectively
has
potential
more
complex
Язык: Английский