Theranostics, Год журнала: 2023, Номер 13(15), С. 5386 - 5417
Опубликована: Янв. 1, 2023
Stimuli-activatable strategies prevail in the design of nanomedicine for cancer theranostics.Upon exposure to endogenous/exogenous stimuli, stimuli-activatable could be self-assembled, disassembled, or functionally activated improve its biosafety and diagnostic/therapeutic potency.A myriad tumor-specific features, including a low pH, high redox level, overexpressed enzymes, along with exogenous physical stimulation sources (light, ultrasound, magnet, radiation) have been considered nano-medicinal products.Recently, novel stimuli explored elegant designs emerged nanomedicine.In addition, multi-functional theranostic has employed imaging-guided image-assisted antitumor therapy.In this review, we rationalize development clinical pressing needs.Stimuli-activatable self-assembly, disassembly functional activation approaches developing realize better efficacy are elaborated state-of-the-art advances their structural detailed.A reflection, status, future perspectives provided.
Язык: Английский
Процитировано
148Terahertz wave alleviates comorbidity anxiety in pain by reducing the binding capacity of nanostructured glutamate molecules to GluA2
Research, Год журнала: 2024, Номер 7
Опубликована: Янв. 1, 2024
Comorbid anxiety in chronic pain is clinically common, with a comorbidity rate of over 50%. The main treatments are based on pharmacological, interventional, and implantable approaches, which have limited efficacy carry risk side effects. Here, we report terahertz (THz, 10 12 Hz) wave stimulation (THS) technique, exerts nonthermal, long-term modulatory effects neuronal activity by reducing the binding between nano-sized glutamate molecules GluA2, leading to relief comorbid anxiety-like behaviors mice. In mice co-occurring induced complete Freund’s adjuvant (CFA) injection, hyperactivity was observed glutamatergic neurons anterior cingulate cortex (ACC Glu ). Using whole-cell recording ACC slices, demonstrated that THS (34 THz) effectively inhibited excitability . Moreover, molecular dynamics simulations showed reduced number hydrogen bonds bound GluA2. Furthermore, target CFA-treatment suppressed and, as result, alleviated behaviors. Consistently, inhibition chemogenetics mimics THS-induced antinociceptive antianxiety behavior. Together, our study provides evidence for an intervention technique modulating viable clinical treatment strategy anxiety.
Язык: Английский
Процитировано
28A Nanographene‐Porphyrin Hybrid for Near‐Infrared‐Ii Phototheranostics
Advanced Science, Год журнала: 2024, Номер 11(18)
Опубликована: Март 2, 2024
Abstract Photoacoustic imaging (PAI)‐guided photothermal therapy (PTT) in the second near‐infrared (NIR‐II, 1000–1700 nm) window has been attracting attention as a promising cancer theranostic platform. Here, it is reported that π‐extended porphyrins fused with one or two nanographene units (NGP‐1 and NGP‐2) can serve new class of NIR‐responsive organic agents, displaying absorption extending to ≈1000 ≈1400 nm NIR‐I NIR‐II windows, respectively. NGP‐1 NGP‐2 are dispersed water through encapsulation into self‐assembled nanoparticles (NPs), achieving high conversion efficiency 60% 69%, respectively, under 808 1064 laser irradiation. Moreover, NIR‐II‐active NGP‐2‐NPs demonstrated photoacoustic responses, along photostability biocompatibility, enabling PAI efficient PTT vivo.
Язык: Английский
Процитировано
25Recent advances in the design of organic photothermal agents for cancer treatment: A review
Coordination Chemistry Reviews, Год журнала: 2024, Номер 506, С. 215719 - 215719
Опубликована: Фев. 24, 2024
Язык: Английский
Процитировано
23Gene and Photothermal Combination Therapy: Principle, Materials, and Amplified Anticancer Intervention
Small, Год журнала: 2023, Номер 20(6)
Опубликована: Сен. 29, 2023
Gene therapy (GT) and photothermal (PTT) have emerged as promising alternatives to chemotherapy radiotherapy for cancer treatment, offering noninvasiveness reduced side effects. However, their efficacy standalone treatments is limited. GT exhibits slow response rates, while PTT confined local tumor ablation. The convergence of PTT, known GT-PTT, facilitated by gene nanocarriers, has attracted considerable attention across various disciplines. In this integrated approach, reciprocates sensitizing cellular heat, benefits improving translocation, unpacking, expression. Consequently, integration presents a unique opportunity with rapid improved effectiveness. Extensive efforts over the past few years been dedicated development resulting in notable achievements progress from laboratory potential clinical applications. This comprehensive review outlines recent advances including synergistic mechanisms, material systems, imaging-guided therapy, anticancer It also explores challenges future prospects nascent field. By presenting innovative ideas insights into implementation GT-PTT enhanced aims inspire further area research.
Язык: Английский
Процитировано
36Two Key Descriptors for Designing Second Near-Infrared Dyes and Experimental Validation
Journal of the American Chemical Society, Год журнала: 2024, Номер 146(14), С. 9888 - 9896
Опубликована: Март 28, 2024
Second near-infrared (NIR-II) optical imaging technology has emerged as a powerful tool for diagnostic and image-guided surgery due to its higher contrast. However, general strategy efficiently designing NIR-II organic molecules is still lacking, because dyes are usually difficult synthesize, which impeded the rapid development of bioprobes. Herein, based on theoretical calculations 62 multiaryl-pyrrole (MAP) systems with spectra ranging from visible region, continuous red shift toward region could be achieved by adjusting type site substituents MAPs. Two descriptors (ΔEgs μgs) were identified exhibiting strong correlations maximum absorption/emission wavelengths, used predict emission spectrum in only if ΔEgs ≤ 2.5 eV μgs 22.55 D. The experimental absorption ten MAPs fully confirmed predictions, biological vivo newly designed MAP23-BBT showed high spatial resolution deep tissue angiography. More importantly, both have shown applicability most reported donor–acceptor–donor-type non-MAP dyes. These results broad implications efficient design
Язык: Английский
Процитировано
17Mitochondrial‐Targeted CS@KET/P780 Nanoplatform for Site‐Specific Delivery and High‐Efficiency Cancer Immunotherapy in Hepatocellular Carcinoma
Advanced Science, Год журнала: 2024, Номер 11(14)
Опубликована: Фев. 2, 2024
Abstract Hepatocellular carcinoma (HCC) is a form of malignancy with limited curative options available. To improve therapeutic outcomes, it imperative to develop novel, potent modalities. Ketoconazole (KET) has shown excellent efficacy against HCC by eliciting apoptosis. However, its water solubility hampers application in clinical treatment. Herein, mitochondria‐targeted chemo‐photodynamic nanoplatform, CS@KET/P780 NPs, designed using nanoprecipitation strategy integrating newly synthesized photosensitizer (P780) and chemotherapeutic agent KET coated chondroitin sulfate (CS) amplify therapy. In this CS confers tumor‐targeted subsequently pH‐responsive drug delivery behavior binding glycoprotein CD44, leading the release P780 KET. Mechanistically, following laser irradiation, targets destroys mitochondrial integrity, thus inducing apoptosis through enhancement reactive oxygen species (ROS) buildup. Meanwhile, KET‐induced synergistically enhances anticancer effect P780. addition, tumor cells undergoing can trigger immunogenic cell death (ICD) longer‐term antitumor response releasing tumor‐associated antigens (TAAs) damage‐associated molecular patterns (DAMPs), which together contribute improved outcomes HCC. Taken together, NPs bioavailability exhibit exerting chemophototherapy immunity.
Язык: Английский
Процитировано
13Apoptosis‐Sensitizing Tumor Nanomedicine by Regulating Pyroptosis‐Associated Inflammatory Cell Death
Advanced Functional Materials, Год журнала: 2024, Номер 34(44)
Опубликована: Май 25, 2024
Abstract The vigorous development of cancer nanomedicine has revolutionized traditional oncology medicine, but it is also limited by the continuous mutation cunning cells, leading to apoptosis insensitivity and therapeutic disappointment. Inflammatory‐regulated cell death (RCD), especially pyroptosis‐related death, demonstrates huge potential for sensitization due its unique biochemical characteristics. aim this research present a thorough synopsis current knowledge on pyroptosis‐associated inflammatory including pyroptosis, cuproptosis, PANoptosis, synergistic function in nano therapy. Paradigm studies death‐mediated apoptosis‐sensitizing tumor nanotherapeutics are introduced detail, coordination mechanisms based nanomaterials discussed. In addition, multi‐angle analysis future prospects pyroptosis‐sensitized various emphasized further expand application scope RCD. It believed that emerging auxiliary treatments RCD will greatly promote progress nanomedicine.
Язык: Английский
Процитировано
10USP18 Antagonizes Pyroptosis by Facilitating Selective Autophagic Degradation of Gasdermin D
Research, Год журнала: 2024, Номер 7
Опубликована: Янв. 1, 2024
As a key executioner of pyroptosis, Gasdermin D (GSDMD) plays crucial role in host defense and emerges as an essential therapeutic target the treatment inflammatory diseases. So far, understanding mechanisms that regulate protein level GSDMD to prevent detrimental effects maintain homeostasis is currently limited. Here, we unveil ubiquitin-specific peptidase 18 (USP18) works negative regulator pyroptosis by targeting for degradation preventing excessive innate immune responses. Mechanically, USP18 recruits E3 ubiquitin ligase mind bomb homolog 2 (MIB2) catalyze ubiquitination on at lysine (K) 168, which acts recognition signal selective autophagic GSDMD. We further confirm alleviating effect LPS-triggered inflammation vivo. Collectively, our study demonstrates regulating GSDMD-mediated reveals previously unknown mechanism rigorously controlled autophagy.
Язык: Английский
Процитировано
8Engineering aggregates of julolidine-substituted aza-BODIPY nanoparticles for NIR-II photothermal therapy
Chinese Chemical Letters, Год журнала: 2024, Номер 35(12), С. 109735 - 109735
Опубликована: Март 8, 2024
Язык: Английский
Процитировано
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