Brain Short-Chain Fatty Acids Induce ACSS2 to Ameliorate Depressive-Like Behavior via PPARγ–TPH2 Axis DOI Creative Commons
Nuo Chen, Xinyi Xu, Yaxin Guo

и другие.

Research, Год журнала: 2024, Номер 7

Опубликована: Янв. 1, 2024

Short-chain fatty acids (SCFAs) have been increasingly evidenced to be important bioactive metabolites of the gut microbiota and transducers in controlling diverse psychiatric or neurological disorders via microbiota–gut–brain axis. However, precise mechanism by which brain SCFAs extert multiple beneficial effects is not completely understood. Our previous research has demonstrated that acetyl-coenzyme A synthetase short-chain family member 2 (ACSS2) a novel target rapid long-lasting antidepressant responses. Here, we show micromolar significantly augment both total cellular nuclear ACSS2 trigger tryptophan hydroxylase (TPH2) promoter histone acetylation its transcription SH-SY5Y cells. In chronic-restraint-stress-induced depression mice, neuronal knockdown stereotaxic injection adeno-associated virus hippocampus abolished SCFA-mediated improvements depressive-like behaviors supporting required for Mechanistically, peroxisome-proliferator-activated receptor gamma (PPARγ) identified as partner activate TPH2 transcription. Importantly, PPARγ also responsible antidepressant-like ACSS2–TPH2 To further support therapeutic effects, d -mannose, naturally present hexose, can reverse dysbiosis chronic-restraint-stress-exposure mice protect against ACSS2–PPARγ–TPH2 summary, axis play antidepressive-like -mannose suggested an inducer resisting depression.

Язык: Английский

4,4-Dimethylsterols Reduces Fat Accumulation via Inhibiting Fatty Acid Amide Hydrolase In Vitro and In Vivo DOI Creative Commons
Tao Zhang, Liangliang Xie, Yiwen Guo

и другие.

Research, Год журнала: 2024, Номер 7

Опубликована: Янв. 1, 2024

4,4-Dimethylsterols constitute a unique class of phytosterols responsible for regulating endogenous cannabinoid system (ECS) functions. However, precise mechanism through which 4,4-dimethylsterols affect fat metabolism and the linkage to ECS remain unresolved. In this study, we identified that 4,4-dimethylsterols, distinct from 4-demethseterols, act as inhibitors fatty acid amide hydrolases (FAAHs) both in vivo vitro. Genetic ablation FAAHs ( faah-1 ) abolishes effects on accumulation locomotion behavior Caenorhabditis elegans model. We confirmed dietary intervention with high-fat diet (HFD) mouse model leads significant reduction body weight (>11.28%) improved lipid profiles liver adipose tissues increased fecal triacylglycerol excretion. Untargeted targeted metabolomics further verified influence unsaturated biosynthesis elevate oleoyl ethanolamine levels intestine. propose potential molecular engage binding interactions catalytic pocket (Ser241) FAAH-1 protein due shielded polarity, arising presence 2 additional methyl groups (CH 3 ). Consequently, represent an unexplored beneficial coordinate activity reduce accumulation, offers new insight into strategies treating diet-induced obesity.

Язык: Английский

Процитировано

7
Erratum to “Sleep Promotion by 3-Hydroxy-4-iminobutyric Acid in Walnut Diaphragma Juglandis Fructus ” DOI Creative Commons
Jian Ji, Yongli Ye,

Lina Sheng

и другие.

Research, Год журнала: 2025, Номер 8

Опубликована: Янв. 1, 2025

[This corrects the article DOI: 10.34133/research.0216.].

Язык: Английский

Процитировано

0
Foods for Sleep Improvement: A Review of the Potential and Mechanisms Involved DOI Creative Commons
Rui Fan, Yingmin Jia, Zhou Chen

и другие.

Foods, Год журнала: 2025, Номер 14(7), С. 1080 - 1080

Опубликована: Март 21, 2025

Insomnia affects one-third of the world’s population; negative effects insomnia are significant, and traditional medications have numerous side cause considerable suffering. This has aroused interest in obtaining sleep-improving substances from foods. study conducted a comprehensive literature review using Web Science PubMed with keywords like “sleep”, “insomnia”, “food”. A subsequent summary revealed that certain foods, including milk, Ziziphus jujuba, Lactuca sativa, ginseng, Schisandra chinensis, Juglans regia, etc., purported to enhance sleep quality by prolonging duration, reducing latency, alleviating anxiety. The mechanisms these foods’ mainly occur via central nervous system, particularly gamma-aminobutyric acid (GABA)ergic 5-hydroxytryptamine (5-HT)ergic systems. Although this supports fact they potential, further research is needed. There also issues such as more limited fewer mechanisms, pharmacokinetic studies, models being involved. These need be addressed future adequately address problem insomnia. It hoped will contribute into foods properties and, future, provide an effective natural alternative for those seeking medication.

Язык: Английский

Процитировано

0
Brain Short-Chain Fatty Acids Induce ACSS2 to Ameliorate Depressive-Like Behavior via PPARγ–TPH2 Axis DOI Creative Commons
Nuo Chen, Xinyi Xu, Yaxin Guo

и другие.

Research, Год журнала: 2024, Номер 7

Опубликована: Янв. 1, 2024

Short-chain fatty acids (SCFAs) have been increasingly evidenced to be important bioactive metabolites of the gut microbiota and transducers in controlling diverse psychiatric or neurological disorders via microbiota–gut–brain axis. However, precise mechanism by which brain SCFAs extert multiple beneficial effects is not completely understood. Our previous research has demonstrated that acetyl-coenzyme A synthetase short-chain family member 2 (ACSS2) a novel target rapid long-lasting antidepressant responses. Here, we show micromolar significantly augment both total cellular nuclear ACSS2 trigger tryptophan hydroxylase (TPH2) promoter histone acetylation its transcription SH-SY5Y cells. In chronic-restraint-stress-induced depression mice, neuronal knockdown stereotaxic injection adeno-associated virus hippocampus abolished SCFA-mediated improvements depressive-like behaviors supporting required for Mechanistically, peroxisome-proliferator-activated receptor gamma (PPARγ) identified as partner activate TPH2 transcription. Importantly, PPARγ also responsible antidepressant-like ACSS2–TPH2 To further support therapeutic effects, d -mannose, naturally present hexose, can reverse dysbiosis chronic-restraint-stress-exposure mice protect against ACSS2–PPARγ–TPH2 summary, axis play antidepressive-like -mannose suggested an inducer resisting depression.

Язык: Английский

Процитировано

2