Effects of Ninjin’yoeito and physical exercise on serum corticosterone and hippocampal BDNF/proBDNF and neuroinflammation in post-stroke depression in rats

BMC Complementary Medicine and Therapies, Год журнала: 2025, Номер 25(1)

Опубликована: Май 13, 2025

Abstract Background Ninjin’yoeito (NYT), a traditional Japanese Kampo medicine, improves the depression and anxiety in humans animals, rendering it novel therapeutic option for post-stroke (PSD). Furthermore, physical exercise is an important nonpharmacological therapy major depressive disorder. The components of NYT or exert antidepressant effects through increased expression neurotrophic factors reduced neuroinflammation brain. However, mechanisms underlying PSD remain unclear. Therefore, we examined rat model PSD. Methods Rats were divided into five groups: PSD, with NYT, (Ex), (NYT + Ex), control (sham). was induced by microinjection endothelin-1 left medial prefrontal cortex chronic unpredictable mild stress 3 days per week. A diet containing 3% administered to rats one day after stroke induction. Exercise conducted using motorized treadmill three week, starting stroke. interventions lasted four weeks. Serum corticosterone levels, depression-like behavior, hippocampal pathophysiology, including brain-derived factor (BDNF), precursor BDNF (proBDNF), doublecortin (DCX), NeuN, glial cell activation, tumor necrosis factor-α (TNF-α), examined. Results levels lower treatment group than those group. Notably, serum significantly CA1 region higher Ex that showed BDNF/proBDNF ratio other groups. DCX NeuN Hippocampal activation TNF-α decreased intervention Conclusions ameliorates Additionally, this study suggested together therapy, may improve neurogenesis, ratio, hippocampus Clinical trial number Not applicable.

Язык: Английский

A pH-Responsive PEG Coating Strategy for Enhancing the Enrichment of Small Extracellular Vesicles towards Disease Regions with Acidic Microenvironment

Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101878 - 101878

Опубликована: Май 1, 2025

Язык: Английский