Regulation of osteoclast-mediated bone resorption by lipids

Bone, Год журнала: 2025, Номер 193, С. 117423 - 117423

Опубликована: Фев. 9, 2025

Язык: Английский

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Injectable mineralized hydrogel microspheres for accelerated osteocyte network reconstruction and intelligent bone regeneration

Journal of Controlled Release, Год журнала: 2025, Номер 380, С. 240 - 255

Опубликована: Фев. 6, 2025

Язык: Английский

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The impact of remnant lipids on keloid formation: a causal analysis using mendelian randomization

Archives of Dermatological Research, Год журнала: 2025, Номер 317(1)

Опубликована: Март 4, 2025

Язык: Английский

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Microbial Influences on Calcium‐Phosphorus Homeostasis and Metabolic Bone Diseases: A Bidirectional Mendelian Randomisation Study on the Gut–Bone Axis

Journal of Cellular and Molecular Medicine, Год журнала: 2025, Номер 29(7)

Опубликована: Апрель 1, 2025

ABSTRACT Observational studies have shown that the gut microbiota (GM) is associated with bone diseases, particularly calcium‐phosphorus metabolic demonstrating existence of a gut–bone axis. However, whether these associations are causal effects remains to be determined. This study employed bidirectional two‐sample Mendelian randomisation (MR) using summary data from Genome‐Wide Association Studies (GWAS) 211 microbial taxa and six diseases (osteoporosis, Osteopenia, osteonecrosis, osteomyelitis, hypoparathyroidism hyperparathyroidism) explore relationships their directionality. Comprehensive sensitivity analyses were conducted ensure robustness results, false discovery rate‐corrected p FDR < 0.05 was used as threshold support strong associations. Additionally, co‐localisation analysis consolidate findings. We identified 35 between GM 17 exhibiting positive 18 negative correlations. Furthermore, reverse MR indicated osteomyelitis elevated abundance two GMs ( 0.05, PP.H4 75%). No evidence horizontal pleiotropy or heterogeneity observed, further strengthened for relationships. The underscores critical role in influencing health through axis, paving way future therapeutic interventions targeting axis offering new directions research metabolism diseases.

Язык: Английский

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Apolipoprotein E as a Potential Regulator of Osteoclast-Osteoblast Coupling in Material-Induced Bone Formation

Acta Biomaterialia, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

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Triglycerides-Total Cholesterol-Body Weight Index, bone metabolism indicators and bone mineral density in Chinese children: a mediation analysis

European Journal of Nutrition, Год журнала: 2025, Номер 64(5)

Опубликована: Май 30, 2025

Язык: Английский

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