Hydrogen sulfide-responsive and depleting NIR-II nanoplatform synergistic photodynamic therapy for colorectal cancer
Yun Chai,
M. Xu,
Ye Sun
и другие.
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 161711 - 161711
Опубликована: Март 1, 2025
Язык: Английский
Constructing J-aggregates of Cyanine Dye for NIR-II in vivo Dynamic Vascular Imaging and Long-Term Targeting of Tumors
Materials Today Bio,
Год журнала:
2025,
Номер
unknown, С. 101693 - 101693
Опубликована: Март 1, 2025
Cyanine
molecules
with
the
second
near-infrared
(NIR-II)
emission
hold
great
potential
for
bioimaging
owing
to
their
biocompatibility,
but
scissor-like
structure
of
these
poses
a
major
bottleneck
in
obtaining
efficient
NIR-II
fluorescence
probes.
Constructing
J-aggregates
represents
promising
strategy
biomedical
emissive
materials.
However,
achieving
cyanine
dyes
large
torsion
angles
between
heterocyclic
rings
challenge.
In
this
study,
we
introduced
guanidine
tumor
molecular
targeted
peptide
1
(TMTP1)
increase
steric
hindrance
IR-783
and
reduce
angle
scissors.
The
near-coplanar
IR-783@peptide
TMTP1
composite
facilitates
formation
novel
(IR-783-LP-TMTP1)
super-stable
effect
vivo
dynamic
vascular
imaging
remarkable
targeting
capability.
stable
wavelength
high
spatial
resolution
was
demonstrated
brain
ear
vasculature
under
808
nm
laser
excitation.
Additionally,
exhibits
robust
tumor-targeting
capability
towards
cervical
tumors,
indicating
cancer
diagnosis.
This
work
develops
design
construct
bright
properties
paving
way
improving
performance
similar
molecules.
Язык: Английский
A multi-modal embolic gel system for long-term fluorescence imaging and photothermal therapy
Biomaterials Advances,
Год журнала:
2025,
Номер
unknown, С. 214298 - 214298
Опубликована: Апрель 1, 2025
Язык: Английский
pH-responsive nanovesicles capable of remodeling the tumor microenvironment enable activatable Near-Infrared-II fluorescence image-guided enhanced radiotherapy
Materials Today Bio,
Год журнала:
2025,
Номер
unknown, С. 101725 - 101725
Опубликована: Апрель 1, 2025
Traditional
radiotherapy
(RT)
lacks
the
precision
to
distinguish
between
tumor
and
normal
tissues,
leading
inevitable
X-ray-induced
side
effects
in
patients.
Therefore,
it
is
crucial
develop
integrated
imaging
therapeutic
modalities
that
can
reduce
on
surrounding
healthy
tissues
while
enhancing
susceptibility
tissues.
In
this
study,
we
developed
a
pH-responsive
nanodrug
(AuNRs-Mn3O4-Ag2S
Ve)
by
self-assembling
second
near-infrared
(NIR-II,
950-1700
nm)
fluorescent
probe
Ag2S
quantum
dots
(QDs),
multifunctional
nanozyme
Mn3O4
nanoparticles
(NPs),
radiosensitizer
gold
nanorods
(AuNRs)
into
single
nanoplatform
via
an
emulsion
process.
This
enables
precise
localization
for
accurately
guided
RT
multi-angle
sensitization
of
RT.
Upon
intravenous
administration,
disintegrates
area
due
pH-sensitive
polymer
P4VP,
releasing
QDs
which
are
specifically
activated
acidic
environment,
thereby
"turning
on"
NIR-II
fluorescence
signal.
The
optimal
timing
signal
within
region
after
injection
was
investigated,
providing
reference
vitro
vivo
experiments
confirmed
efficient
enhancement
radiosensitization
AuNRs
NPs.
specific
modality
transitions
from
"off"
"on"
has
been
successfully
implemented,
addressing
limitations
conventional
radiosensitivity.
integration
approaches
study
presents
promising
image-guided
Язык: Английский