Myeloperoxidase as a therapeutic target for oxidative damage in Alzheimer’s disease DOI Creative Commons

Astrid Mayleth Rivera Antonio,

Itzia I. Padilla‐Martínez, Mónica Torres-Ramos

и другие.

Journal of Enzyme Inhibition and Medicinal Chemistry, Год журнала: 2025, Номер 40(1)

Опубликована: Фев. 14, 2025

Alzheimer's disease (AD) is a major neurodegenerative disorder more common in older adults. One of the leading AD hypotheses involves amyloid beta (A) production, it associated to oxidative stress, neuroinflammation, and neurovascular damage. The interaction A with blood vessel wall contributes disruption blood-brain barrier (BBB), allowing neutrophil infiltration containing myeloperoxidase enzyme (MPO), which produces hypochlorous acid (HOCl) potent oxidant. Also, MPO could be released from microglia cells interact plaques. This review aims study role progression AD, particular its contribution stress neuroinflammation. Furthermore, explore MPO-potential as AD-biomarker evaluate therapeutic potential inhibitors mitigate neurotoxicity. Finally, revise that act dual acting on acetylcholinesterase or another target involved AD.

Язык: Английский

Myeloperoxidase as a therapeutic target for oxidative damage in Alzheimer’s disease DOI Creative Commons

Astrid Mayleth Rivera Antonio,

Itzia I. Padilla‐Martínez, Mónica Torres-Ramos

и другие.

Journal of Enzyme Inhibition and Medicinal Chemistry, Год журнала: 2025, Номер 40(1)

Опубликована: Фев. 14, 2025

Alzheimer's disease (AD) is a major neurodegenerative disorder more common in older adults. One of the leading AD hypotheses involves amyloid beta (A) production, it associated to oxidative stress, neuroinflammation, and neurovascular damage. The interaction A with blood vessel wall contributes disruption blood-brain barrier (BBB), allowing neutrophil infiltration containing myeloperoxidase enzyme (MPO), which produces hypochlorous acid (HOCl) potent oxidant. Also, MPO could be released from microglia cells interact plaques. This review aims study role progression AD, particular its contribution stress neuroinflammation. Furthermore, explore MPO-potential as AD-biomarker evaluate therapeutic potential inhibitors mitigate neurotoxicity. Finally, revise that act dual acting on acetylcholinesterase or another target involved AD.

Язык: Английский

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