Genetic and Pathological Insights into the rs7216389 Polymorphism in Gasdermin B and Its Association with Childhood Asthma DOI Open Access

Qudsia Umaira Khan,

Banu Anlar,

Ismail Mazhar

и другие.

Discoveries, Год журнала: 2024, Номер 12(4), С. e196 - e196

Опубликована: Дек. 31, 2024

This review provides an overview of genetic and pathological mechanisms associated with childhood asthma, focusing on the Gasdermin B (GSDMB) gene variant rs7216389. Accordingly, asthma is outlined as most common chronic disease in children, increased incidence worldwide community, critically important complications, mortality related to severe manifestations, primarily exacerbations. The a clinical definition exacerbation, briefly goes into cost aspects, explains features pediatric compared adult-onset asthma. It recognizes influence factors such single nucleotide polymorphisms at 17q21 locus concerning its attacks while stressing need understand those that could be potential targets for treatment. also stresses difficulties implementing discovery clinic, additional research dedicated unveiling relationship between risk factors, environmental exposures, immune reactions process To this end, current work should viewed attempt provide broad pathogenesis contribute development novel hypotheses therapeutic approaches future studies.

Язык: Английский

Advances in Non-Type 2 Asthma in the Severe Cases: from molecular insights to novel treatment strategies DOI Creative Commons
Tao Liu, Prescott G. Woodruff, Xiaobo Zhou

и другие.

European Respiratory Journal, Год журнала: 2024, Номер 64(2), С. 2300826 - 2300826

Опубликована: Май 2, 2024

Asthma is a prevalent pulmonary disease that affects more than 300 million people worldwide and imposes substantial economic burden. While medication can effectively control symptoms in some patients, severe asthma attacks, driven by airway inflammation induced environmental infectious exposures, continue to be major cause of asthma-related mortality. Heterogeneous phenotypes include type 2 (T2) non-T2 asthma. Non-T2 often observed patients with and/or steroid-resistant This review covers the molecular mechanisms, clinical phenotypes, causes promising treatments Specifically, we discuss signalling pathways for including activation inflammasomes, interferon responses interleukin-17 pathways, their contributions subtypes, progression severity Understanding mechanisms genetic determinants underlying could form basis precision medicine treatment.

Язык: Английский

Процитировано

16
Association of rs7216389 Polymorphism in Gasdermin B (GSDMB) With Childhood Asthma: A Case-Control Study DOI Open Access

Qudsia Umaira Khan,

A. Bano,

Ismail Mazhar

и другие.

Cureus, Год журнала: 2025, Номер unknown

Опубликована: Янв. 5, 2025

Objective This study examines the association between gasdermin B (GSDMB) gene variant rs7216389 and childhood asthma, with a focus on gender-based differences, environmental factors, lung function measurements in affected children. It highlights growing prevalence of its unique features compared to adult-onset substantial healthcare burden it imposes, especially during exacerbations. Methods A case-control was conducted over 18 months at CMH Lahore, UHS, Children's Hospital, including 200 participants (100 asthmatics, 100 controls) aged three 18. Blood samples were analyzed for genetic factors. IBM SPSS Statistics Windows, Version 25.0 (Released 2017; Corp., Armonk, NY, USA) used statistical analysis, significance p < 0.05. Ethical approval informed consent obtained. Results The identifies GSDMB as potential marker underscoring severity condition challenges translating findings into clinical practice while emphasizing therapeutic targeting these markers. also sheds light costs distinctive pediatric further contextualizing impact. Conclusions article provides comprehensive overview asthma pathogenesis, markers like gene. advocates research unravel complex interplay genetic, environmental, immune factors intending develop targeted interventions.

Язык: Английский

Процитировано

0
The immune system in cardiovascular diseases: from basic mechanisms to therapeutic implications DOI Creative Commons
Xiaoyan Wang, Liming Chen,

Jianming Wei

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)

Опубликована: Май 22, 2025

Abstract Immune system plays a crucial role in the physiological and pathological regulation of cardiovascular system. The exploration history milestones immune diseases (CVDs) have evolved from initial discovery chronic inflammation atherosclerosis to large-scale clinical studies confirming importance anti-inflammatory therapy treating CVDs. This progress has been facilitated by advancements various technological approaches, including multi-omics analysis (single-cell sequencing, spatial transcriptome et al.) significant improvements immunotherapy techniques such as chimeric antigen receptor (CAR)-T cell therapy. Both innate adaptive immunity holds pivotal CVDs, involving Toll-like (TLR) signaling pathway, nucleotide-binding oligomerization domain-containing proteins 1 2 (NOD1/2) inflammasome RNA DNA sensing well antibody-mediated complement-dependent systems. Meanwhile, responses are simultaneously regulated multi-level regulations epigenetics (DNA, RNA, protein) other key pathways interactions among cells, between cardiac or vascular cells. Remarkably, based on basic research system, also made pre-clinical immunotherapy. review provides an overview providing in-depth insights into highlighting impact Finally, we discuss strategies targeting translational implications

Язык: Английский

Процитировано

0
The role of the cGAS-STING pathway in chronic pulmonary inflammatory diseases DOI Creative Commons

Mengxiang Tian,

Fengyuan Li, Haiping Pei

и другие.

Frontiers in Medicine, Год журнала: 2024, Номер 11

Опубликована: Окт. 30, 2024

The innate immune system plays a vital role in the inflammatory process, serving as crucial mechanism for body to respond infection, cellular stress, and tissue damage. cGAS-STING signaling pathway is pivotal onset progression of various autoimmune diseases chronic inflammation. By recognizing cytoplasmic DNA, this initiates regulates inflammation antiviral responses within system. Consequently, regulation has become prominent area interest treatment many diseases. Chronic lung diseases, such obstructive pulmonary disease (COPD), asthma, fibrosis, are characterized by persistent or recurrent damage, leading diminished respiratory function. This paper explores action these examines development STING inhibitors nanomaterial applications, discusses potential clinical application prospects targeting

Язык: Английский

Процитировано

2
Genetic and Pathological Insights into the rs7216389 Polymorphism in Gasdermin B and Its Association with Childhood Asthma DOI Open Access

Qudsia Umaira Khan,

Banu Anlar,

Ismail Mazhar

и другие.

Discoveries, Год журнала: 2024, Номер 12(4), С. e196 - e196

Опубликована: Дек. 31, 2024

This review provides an overview of genetic and pathological mechanisms associated with childhood asthma, focusing on the Gasdermin B (GSDMB) gene variant rs7216389. Accordingly, asthma is outlined as most common chronic disease in children, increased incidence worldwide community, critically important complications, mortality related to severe manifestations, primarily exacerbations. The a clinical definition exacerbation, briefly goes into cost aspects, explains features pediatric compared adult-onset asthma. It recognizes influence factors such single nucleotide polymorphisms at 17q21 locus concerning its attacks while stressing need understand those that could be potential targets for treatment. also stresses difficulties implementing discovery clinic, additional research dedicated unveiling relationship between risk factors, environmental exposures, immune reactions process To this end, current work should viewed attempt provide broad pathogenesis contribute development novel hypotheses therapeutic approaches future studies.

Язык: Английский

Процитировано

0