Clinicopathological Studies on the Impact of Grape Seed Extract and L-Carnitine as Cardioprotective Agents Against Doxorubicin-Induced Toxicity in Rats DOI Creative Commons
Tahany Saleh Aldayel, Omnia Kilany, Heba Nageh Gad El-Hak

и другие.

Life, Год журнала: 2024, Номер 14(12), С. 1656 - 1656

Опубликована: Дек. 13, 2024

Doxorubicin (DOX) cancer therapy induces serious cardiotoxicity as a side effect. This study aimed to investigate the cardioprotective effects of grape seed extract (GSE) and L-Carnitine (L-CA) against DOX-induced cardiac toxicity in male rats. Six groups albino rats were used: G1 (control); G2 (GSE), given (100 mg/kg b.wt.) orally for 35 days; G3 (150 b.wt.); Group 4 (DOX-induced cardiotoxicity), DOX (10 b.wt., i.p.) on 28th day experiment; G5 (GSE + DOX), GSE previously mentioned; G6 (L-CA L-CA mentioned. Electrocardiographic evaluation, lipid profile, peroxidation antioxidants, serum markers, inflammatory markers estimated. Histopathological evaluation tissue was also examined. Key findings showed that induced ECG abnormalities peroxidation, reduced elevated markers. significantly ameliorated abnormalities, improved antioxidant enzymes inflammation. These suggest exhibit substantial via their anti-inflammatory potentials.

Язык: Английский

Clinicopathological Studies on the Impact of Grape Seed Extract and L-Carnitine as Cardioprotective Agents Against Doxorubicin-Induced Toxicity in Rats DOI Creative Commons
Tahany Saleh Aldayel, Omnia Kilany, Heba Nageh Gad El-Hak

и другие.

Life, Год журнала: 2024, Номер 14(12), С. 1656 - 1656

Опубликована: Дек. 13, 2024

Doxorubicin (DOX) cancer therapy induces serious cardiotoxicity as a side effect. This study aimed to investigate the cardioprotective effects of grape seed extract (GSE) and L-Carnitine (L-CA) against DOX-induced cardiac toxicity in male rats. Six groups albino rats were used: G1 (control); G2 (GSE), given (100 mg/kg b.wt.) orally for 35 days; G3 (150 b.wt.); Group 4 (DOX-induced cardiotoxicity), DOX (10 b.wt., i.p.) on 28th day experiment; G5 (GSE + DOX), GSE previously mentioned; G6 (L-CA L-CA mentioned. Electrocardiographic evaluation, lipid profile, peroxidation antioxidants, serum markers, inflammatory markers estimated. Histopathological evaluation tissue was also examined. Key findings showed that induced ECG abnormalities peroxidation, reduced elevated markers. significantly ameliorated abnormalities, improved antioxidant enzymes inflammation. These suggest exhibit substantial via their anti-inflammatory potentials.

Язык: Английский

Процитировано

0