Criterion validity of the genetic addiction risk severity (GARS) as a marker of reward deficiency in polydrug addiction: a multi-center study

Journal of Translational Genetics and Genomics, Год журнала: 2025, Номер 9(2), С. 76 - 100

Опубликована: Март 24, 2025

Aim : This study evaluated the Genetic Addiction Risk Severity (GARS) panel, which assesses genetic predisposition to addictive disorders by examining eleven polymorphisms in ten genes associated with dopaminergic reward system functioning. Methods The GARS registered mark instead panel includes six single-nucleotide [DRD1, DRD2, DRD3, DRD4, OPRM1, and catechol-O-methyltransferase (COMT )], four simple sequence repeats (5HTT, DAT1, MAOA ), one dinucleotide repeat (GABRA3 ). Criterion validity was tested 393 polydrug abusers correlating scores Index-Multimedia Version (ASI-MV) alcohol drug severity scores. Results We identified a significant correlation between ASI-MV score. While individuals elevated also exhibited increased GARS, relationship did not follow strictly linear pattern. Variations multiple involved signaling contributed risk an additive manner, age serving as covariate. A greater number (≥ 7) of gene moderate reductions dopamine demonstrated association higher In contrast, possessing or more significantly Conclusion: Our findings align previous research implicating pathways progression alcoholism substance abuse. Additionally, they build upon prior work identifying potential pre-existing polygenic factor, defined that may be influenced age-related physiological changes environmental factors. Further is warranted explore endophenotypes, particular emphasis on role Reward Deficiency Syndrome linked dysfunction within system.

Язык: Английский

Genes and Genetic Testing in Addiction Medicine

Elsevier eBooks, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Язык: Английский