The Role of Monocyte Distribution Width (MDW) in the Prediction of Death in Adult Patients with Sepsis
Microorganisms,
Год журнала:
2025,
Номер
13(2), С. 427 - 427
Опубликована: Фев. 15, 2025
Sepsis
is
a
life-threatening
condition;
it
major
cause
of
hospital
mortality
worldwide
and
constitutes
global
health
problem.
This
research
investigates
the
use
MDW
as
predictor
for
septic
patients.
was
double-center
prospective
cohort
study
adult
Septic
patients
were
identified
categorized
into
two
categories:
those
who
improved
died.
Blood
drawn
from
three
times,
on
first,
third,
fifth
day
their
admission
to
hospital.
evaluated
biomarker
predict
patient
outcome.
In
addition,
existing
inflammatory
markers
recorded
in
all
The
able
patient's
average
found
be
significantly
higher
died
records.
For
example,
an
value
28.4
first
shown
best
cut-off
determining
fatal
outcomes;
receiver
operating
characteristic
(ROC)
analysis
revealed
area
under
curve
0.71
(95%
Confidence
Interval-CI:
0.57-0.84)
with
sensitivity
64.7%
specificity
88.2%.
conclusion,
MDW,
addition
being
marker
that
can
quickly
detect
sepsis
more
effectively
than
other
biomarkers,
which
proven
by
numerous
studies,
could
also
used
indicator
work
attempt
direction.
Язык: Английский
Monocyte distribution width as an early predictor of short-term outcome in adult patients with sepsis
Clinical Chemistry and Laboratory Medicine (CCLM),
Год журнала:
2023,
Номер
62(3), С. 562 - 571
Опубликована: Окт. 10, 2023
Monocyte
distribution
width
(MDW)
is
a
quantitative
measurement
of
monocyte
anisocytosis
and
has
been
proposed
as
an
efficient
marker
for
early
sepsis
detection.
This
study
aimed
to
assess
the
prognostic
potential
MDW
in
septic
patients.
Язык: Английский
The Need for Standardized Guidelines for the Use of Monocyte Distribution Width (MDW) in the Early Diagnosis of Sepsis
Journal of Personalized Medicine,
Год журнала:
2024,
Номер
15(1), С. 5 - 5
Опубликована: Дек. 27, 2024
Sepsis
is
a
complex
and
potentially
life-threatening
syndrome
characterized
by
an
abnormal
immune
response
to
infection,
which
can
lead
organ
dysfunction,
septic
shock,
death.
Early
diagnosis
crucial
improving
prognosis
reducing
hospital
management
costs.
This
narrative
review
aims
summarize
evaluate
the
current
literature
on
role
of
monocyte
distribution
width
(MDW)
as
diagnostic
biomarker
for
sepsis,
highlighting
its
advantages,
limitations,
potential
clinical
applications.
MDW
measures
volumetric
monocytes,
reflecting
monocytic
anisocytosis,
detected
using
advanced
hematological
analyzers.
In
2019,
it
was
approved
FDA
sepsis
due
ability
identify
systemic
inflammatory
at
early
stage.
Thirty-one
studies
analyzed
us
have
shown
that
increased
value
associated
with
higher
risk
combination
parameters
(such
qSOFA)
other
biomarkers
(CRP,
PCT)
enhance
sensitivity
stratification
capacity.
Despite
high
sensitivity,
has
lower
specificity
compared
more
established
such
procalcitonin,
thus
requiring
multimodal
integration
accurate
diagnosis.
The
use
in
emergency
intensive
care
settings
represents
opportunity
improve
critical
patient
management,
particularly
when
combined
markers
tools.
However,
further
are
needed
define
universal
cut-off
confirm
validity
different
contexts
pathological
scenarios.
Язык: Английский