Metabolic Syndrome, Thyroid Dysfunction, and Cardiovascular Risk: The Triptych of Evil DOI Open Access
Alessandro Pingitore, Melania Gaggini, Francesca Mastorci

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(19), С. 10628 - 10628

Опубликована: Окт. 2, 2024

The triad formed by thyroid dysfunction, metabolic syndrome (MetS), and cardiovascular (CV) risk forms a network with many connections that aggravates health outcomes. Thyroid hormones (THs) play an important role in glucose lipid metabolism hemodynamic regulation at the molecular level. It is noteworthy bidirectional association between THs MetS their components likely exists as leads to whereas alterations may cause higher incidence of MetS. dysfunction increases insulin resistance, circulating levels lipids, particular LDL-C, VLDL-C, triglycerides, induces endothelial dysfunction. Furthermore, are regulators both white brown adipose tissue. Moreover, pathophysiological relationship TH made even tighter considering these conditions usually associated inflammatory activation increased oxidative stress. Therefore, takes place starting from level, then manifesting itself clinical through CV events general population well patients heart failure or acute myocardial infarction. Thus, frequently which supports need assess function this group, when clinically indicated, correct it maintain euthyroidism. However, there still several critical points be further investigated treat subclinical dysthyroidism patients.

Язык: Английский

Metabolic Syndrome, Thyroid Dysfunction, and Cardiovascular Risk: The Triptych of Evil DOI Open Access
Alessandro Pingitore, Melania Gaggini, Francesca Mastorci

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(19), С. 10628 - 10628

Опубликована: Окт. 2, 2024

The triad formed by thyroid dysfunction, metabolic syndrome (MetS), and cardiovascular (CV) risk forms a network with many connections that aggravates health outcomes. Thyroid hormones (THs) play an important role in glucose lipid metabolism hemodynamic regulation at the molecular level. It is noteworthy bidirectional association between THs MetS their components likely exists as leads to whereas alterations may cause higher incidence of MetS. dysfunction increases insulin resistance, circulating levels lipids, particular LDL-C, VLDL-C, triglycerides, induces endothelial dysfunction. Furthermore, are regulators both white brown adipose tissue. Moreover, pathophysiological relationship TH made even tighter considering these conditions usually associated inflammatory activation increased oxidative stress. Therefore, takes place starting from level, then manifesting itself clinical through CV events general population well patients heart failure or acute myocardial infarction. Thus, frequently which supports need assess function this group, when clinically indicated, correct it maintain euthyroidism. However, there still several critical points be further investigated treat subclinical dysthyroidism patients.

Язык: Английский

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