Rosaceae Honey: Antimicrobial Activity and Prebiotic Properties

Antibiotics, Год журнала: 2025, Номер 14(3), С. 298 - 298

Опубликована: Март 13, 2025

Background: Flowering members of the globally diffused Rosaceae family include popular plants, such as apple, almond, and cherry, which play a fundamental role honeybee nectariferous polleniferous agents. Through production honey, these plants can also an indirect in prevention treatment many diseases, including infections, fighting occurrence resistant microorganisms, concurrently stimulating growth beneficial bacteria. Objectives: This study focused on effect some plants’ hawthorn, raspberry, against pathogens Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Listeria monocytogenes, Pseudomonas aeruginosa, Staphylococcus aureus. Results: Results demonstrated honey’s ability to impair swimming motility. A crystal violet test indicated that honey could inhibit formation stabilization biofilms, with inhibition rates up 59.43% for immature biofilms (showed by apple A. baumannii) 39.95% sessile bacterial cells mature (when we used cherry S. aureus). In 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, were most effective inhibiting cell metabolism both (56.47% vs. K. pneumoniae) (54.36% baumannii). Honey stimulated Lactobacillus bulgaricus, Lacticaseibacillus casei Shirota, gasseri, plantarum, rhamnosus; almond significantly increased vitro adhesion capacity L. bulgaricus Shirota. Tests probiotic supernatants biofilm pathogens. Conclusions: Our results encourage further studies assess potential application food preservation health field, it fight antimicrobial resistance clinical pathogens, potentially enhance host’s gut wellness. The use nanotechnological biotechnological approaches be suggested too.

Язык: Английский

Synergy, Additive Effects, and Antagonism of Drugs with Plant Bioactive Compounds

Drugs and Drug Candidates, Год журнала: 2025, Номер 4(1), С. 4 - 4

Опубликована: Фев. 5, 2025

Background/Objectives: The interaction of bioactive compounds derived from plants with drugs has become a significant area investigation due to its potential improve, reduce, or have no effect on therapeutic outcomes. Due the dual these interactions, elucidating underlying mechanisms is essential for establishing strategy. This study emphasizes findings, mechanisms, and clinical implications drug–plant interactions. It calls more studies seek safe effective incorporation into practice. Methods: To identify relevant studies, we performed systematic literature search based various scientific databases 11 August 2024 30 December 2024. will be keywords such as synergy, antagonism, plant compounds, drug interactions supplemented secondary terms phytochemicals, herb-drug pharmacokinetics, pharmacodynamics. Results: Plant bioactives, including polyphenols, flavonoids, alkaloids, terpenoids, display valuable biological activities that can interact medications in three principal ways: additive effects, antagonism. Synergy occurs when combined effects chemicals pharmaceuticals outweigh sum their separate increasing effectiveness allowing dosage decrease reduce adverse effects. Additive occur impact equals total individual resulting better outcomes without risk. Antagonism ingredient reduces counteracts medicine, thereby jeopardizing treatment. In addition, specific may discernible effect. chemical makeup chemicals, medication patient characteristics genetics metabolism all intricacy Conclusions: Pharmacokinetics pharmacodynamics considerably modulated through components, which cause efficacy increase toxicity agents. More are needed clarify action, prove relevance, create guidelines co-administration. integrative approach mitigate those risks allow optimization by introducing pharmacogenomics personalized medicine approaches.

Язык: Английский