Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ), Год журнала: 2025, Номер 8(1), С. 208 - 214
Опубликована: Март 16, 2025
Background: Thyroid disorders are a major clinical concern that negatively impacts the thyroid gland. issues have been connected to FOXP3 gene, which is an important immune system regulator. protein levels can be affected by genetic differences, may impair regulatory T-cell activity and exacerbate immunological abnormalities. Objectives: To investigate influence of gene polymorphisms on circulating their association with dysfunction. Methods: This study included 100 patients 50 healthy controls. function was assessed measuring serum T3, T4, TSH using Cobas analyzer. Serum were quantified ELISA. Genomic DNA extracted analyzed for variations PCR sequencing. Results: No significant differences observed in T3 T4 between However, significantly elevated patient group. lower compared The distribution three genotypes (AA, AC, CC) did not differ Individuals heterozygous (AC) genotype exhibited higher other two genotypes. Conclusions: had reduced FOXP3, indicate disease impaired immunity. emphasizes complicated interaction environmental factors, even if it could identify obvious connection rs3761548 variation.
Язык: Английский