Therapeutic Implications of Probiotics in the Gut Microbe-Modulated Neuroinflammation and Progression of Alzheimer’s Disease
Life,
Год журнала:
2023,
Номер
13(7), С. 1466 - 1466
Опубликована: Июнь 28, 2023
Alzheimer’s
disease
(AD)
is
characterized
by
the
accumulation
of
specific
proteins
in
brain.
A
recent
study
revealed
that
manipulating
gut
microbiota
(GM)
significantly
reduced
tau
pathology
and
neurodegeneration
an
apolipoprotein
E
isoform-dependent
manner.
The
resilience
a
healthy
protects
it
from
variety
dysbiosis-related
pathologies.
Convincing
evidence
has
demonstrated
roles
GM
pathogenesis
AD,
which
are
partly
mediated
modified
microglial
activity
Therefore,
modulation
may
be
promising
therapeutic
option
for
AD
prevention.
In
addition
to
providing
cells
with
energy
affecting
maturation,
these
microbial
metabolites
appear
influence
neuronal
function.
One
potential
approaches
targeting
involve
using
probiotics.
Additionally,
human
its
have
also
become
targets
developing
interventions
prevention
disorders.
Synbiotics
postbiotics
can
used
treat
modulating
GM.
addition,
physical
activity,
exercise,
fitness
being
considered
as
nonpharmacological
therapies
reduce
signaling
pathways
related
neuroinflammation.
might
strategies
health
promotion.
Язык: Английский
Potential Molecular Mechanisms of Alcohol Use Disorder with Non-Coding RNAs and Gut Microbiota for the Development of Superior Therapeutic Application
Genes,
Год журнала:
2024,
Номер
15(4), С. 431 - 431
Опубликована: Март 29, 2024
Many
investigations
have
evaluated
the
expression
of
noncoding
RNAs
(ncRNAs)
as
well
their
related
molecular
functions
and
biological
machineries
in
individuals
with
alcohol
dependence.
Alcohol
dependence
may
be
one
most
prevailing
psychological
disorders
globally,
its
pathogenesis
is
intricate
inadequately
comprehended.
There
substantial
evidence
indicating
significant
links
between
multiple
genetic
factors
development
In
particular,
critical
roles
ncRNAs
been
emphasized
pathology
mental
illnesses,
probably
including
comprehension
action
modification,
furthermore,
they
emerged
therapeutic
targets
for
a
variety
psychiatric
It
worth
mentioning
that
dysregulated
has
regularly
detected
An
in-depth
knowledge
m6A
modification
valuable
novel
treatment
against
general,
more
profound
understanding
practical
might
make
important
contributions
to
precise
diagnosis
and/or
actual
management
Here,
this
review,
we
mostly
focused
on
up-to-date
regarding
alterations
modifications
Then,
present
prospects
future
research
applications
concept
engram
system.
Язык: Английский
Potential tactics with certain gut microbiota for the treatment of unresectable hepatocellular carcinoma
Exploration of Targeted Anti-tumor Therapy,
Год журнала:
2023,
Номер
unknown, С. 556 - 568
Опубликована: Авг. 24, 2023
Hepatocellular
carcinoma
(HCC)
constitutes
an
extremely
malignant
form
of
primary
liver
cancer.
Intricate
connections
linking
to
the
immune
system
might
be
associated
with
pathogenesis
HCC.
Meanwhile,
immunotherapy
checkpoint
inhibitors
has
been
established
a
favorable
therapeutic
possibility
for
advanced
Although
curative
opportunities
HCC
are
restricted,
developed
as
main
choice
treating
However,
patients
metabolic-associated
fatty
disease
(MAFLD)-linked
less
likely
benefit
from
alone.
The
limitation
effect
owing
impaired
T
cell
activation
in
MAFLD
patients,
which
could
well
explained
by
dysfunctional
gut-liver
axis.
Gut
microbiota
and
their
metabolites
including
several
bile
acids
contribute
modulating
responses
immunotherapy.
Roles
gut
development
cancers
have
expected
great
interest
latest
studies.
Here,
interplay
between
presented,
suggest
affect
efficacy
against
Язык: Английский