Smart Multi-Responsive Biomaterials and Their Applications for 4D Bioprinting
Jinku Kim,
D.A. Gouripriya,
Poonam Debnath
и другие.
Biomimetics,
Год журнала:
2024,
Номер
9(8), С. 484 - 484
Опубликована: Авг. 11, 2024
The
emergence
of
4D
printing
has
become
a
pivotal
tool
to
produce
complex
structures
in
biomedical
applications
such
as
tissue
engineering
and
regenerative
medicine.
This
chapter
provides
concise
overview
the
current
state
field
its
immense
potential
better
understand
involved
technologies
build
sophisticated
4D-printed
structures.
These
have
capability
sense
respond
diverse
range
stimuli,
which
include
changes
temperature,
humidity,
or
electricity/magnetics.
First,
we
describe
technologies,
extrusion-based
inkjet
printing,
light-based
droplet-based
methods
including
selective
laser
sintering
(SLS).
Several
types
biomaterials
for
can
undergo
structural
various
external
stimuli
over
time
were
also
presented.
hold
promise
revolutionizing
fields
that
require
adaptable
intelligent
materials.
Moreover,
smart
highlighted,
spanning
wide
spectrum
intended
from
drug
delivery
Finally,
address
number
challenges
associated
with
touching
upon
ethical
regulatory
aspects
along
need
standardized
protocols
both
vitro
well
vivo
testing
structures,
are
crucial
steps
toward
eventual
clinical
realization.
Язык: Английский
Revolutionizing healthcare: Emerging frontiers in 3D bioprinting of tissues and organs
Ochieng Ben Omondi,
Yasinta Nida Arroyan,
Benson Onyango
и другие.
European Polymer Journal,
Год журнала:
2024,
Номер
217, С. 113210 - 113210
Опубликована: Июль 18, 2024
Язык: Английский
Smart biomaterials in healthcare: Breakthroughs in tissue engineering, immunomodulation, patient-specific therapies, and biosensor applications
Applied Physics Reviews,
Год журнала:
2025,
Номер
12(1)
Опубликована: Март 1, 2025
Smart
biomaterials
have
significantly
impacted
human
healthcare
by
advancing
the
development
of
medical
devices
designed
to
function
within
tissue,
mimicking
behavior
natural
tissues.
While
intelligence
has
evolved
from
inert
active
over
past
few
decades,
smart
take
this
a
step
further
making
their
surfaces
or
bulk
respond
based
on
interactions
with
surrounding
tissues,
imparting
outcomes
similar
tissue
functions.
This
interaction
helps
in
creating
stimuli-responsive
biomaterials,
which
can
be
useful
engineering,
regenerative
medicine,
autonomous
drug
delivery,
orthopedics,
and
much
more.
Traditionally,
material
engineering
focused
refining
static
properties
accommodate
them
body
without
evoking
an
immune
response,
was
major
obstacle
unrestricted
operation.
review
highlights
explains
various
approaches
currently
under
research
for
developing
that
tune
responses
bodily
factors
like
temperature,
pH,
ion
concentration
external
magnetism,
light,
conductivity.
Applications
soft
hard
4D
printing,
scaffold
design
are
also
discussed.
The
advanced
application
microfluidics,
organ-on-a-chip
models,
extensively
benefits
intrinsic
discussed
below.
elaborates
how
biomaterial
could
revolutionize
biosensor
applications,
thereby
improving
patient
care
quality.
We
delineate
limitations
key
challenges
associated
providing
insights
into
path
forward
outlining
future
directions
next-generation
will
facilitate
clinical
translation.
Язык: Английский
4D Bioprinting for Personalized Medicine, Innovations in Implant Fabrication and Regenerative Therapies
Polymer-Plastics Technology and Materials,
Год журнала:
2025,
Номер
unknown, С. 1 - 26
Опубликована: Март 30, 2025
Язык: Английский
Advances in 4D Bioprinting: The Next Frontier in Regenerative Medicine and Tissue Engineering Applications
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
14(4)
Опубликована: Дек. 29, 2024
4D
bioprinting
is
a
critical
advancement
in
tissue
engineering
and
regenerative
medicine
(TERM),
enabling
the
creation
of
structures
that
dynamically
respond
to
environmental
stimuli
over
time.
This
review
investigates
various
fabrication
techniques
responsive
materials
are
central
these
fields.
It
underscores
integration
multi-material
biocomposite
approaches
bioprinting,
which
crucial
for
fabricating
complex
functional
constructs
with
heterogeneous
properties.
Using
enhances
mimicry
natural
characteristics,
offering
tailored
responses
improved
biological
systems.
Furthermore,
this
study
highlights
synergy
between
demonstrates
technology's
potential
developing
tissues
organs.
In
medicine,
bioprinting's
applications
extend
creating
smart
implants
advanced
drug
delivery
systems
adapt
body's
changes,
promoting
healing
regeneration.
Finally,
challenges
future
directions
also
explored
emphasize
its
transformative
impact
on
biomedical
healthcare.
Язык: Английский
Pilot Evaluation of Silicone Surrogates for Oral Mucosa Simulation in Craniofacial Surgical Training
Опубликована: Июнь 24, 2024
Surgical
simulators
are
crucial
in
early
craniofacial
and
plastic
surgical
training,
necessitating
synthetic
materials
that
accurately
replicate
tissue
properties.
Recent
critiques
of
our
lab’s
currently
deployed
silicone
surrogate
have
highlighted
numerous
areas
for
improvement.
To
further
refine
models,
group's
objective
is
to
find
a
composition
closest
fidelity
native
oral
mucosa
during
rehearsal
by
expert
surgeons.
Fifteen
platinum
silicone-based
samples
were
constructed
with
variable
hardness
slacker
percentages.
These
underwent
evaluation
tactile
sensation,
hardness,
needle
puncture,
cut
resistance,
suture
retention,
defect
repair,
tensile
elasticity.
Expert
surgeon
evaluators
provided
focused
qualitative
feedback
on
selected
top-performing
assessment
statistical
comparisons.
Evaluation
revealed
characteristics
satisfactory
good
performance.
Sample
977
exhibited
the
highest
performance,
comparison
original
(sample
810)
demonstrated
significant
improvements
critical
areas,
emphasizing
efficacy
refined
composition.
The
study
identified
directly
addresses
received
team’s
surrogate.
underscores
delicate
balance
between
biofidelity
practicality
simulation.
need
ongoing
refinement
evident
optimize
training
experiences
learners.
Язык: Английский
Pilot Evaluation of Silicone Surrogates for Oral Mucosa Simulation in Craniofacial Surgical Training
Опубликована: Июль 16, 2024
Surgical
simulators
are
crucial
in
early
craniofacial
and
plastic
surgical
training,
necessitating
synthetic
materials
that
accurately
replicate
tissue
properties.
Recent
critiques
of
our
lab’s
currently
deployed
silicone
surrogate
have
highlighted
numerous
areas
for
improvement.
To
further
refine
models,
group's
objective
is
to
find
a
composition
closest
fidelity
native
oral
mucosa
during
rehearsal
by
expert
surgeons.
Fifteen
platinum
silicone-based
samples
were
constructed
with
variable
hardness
slacker
percentages.
These
underwent
evaluation
tactile
sensation,
hardness,
needle
puncture,
cut
resistance,
suture
retention,
defect
repair,
tensile
elasticity.
Expert
surgeon
evaluators
provided
focused
qualitative
feedback
on
selected
top-performing
assessment
statistical
comparisons.
Evaluation
revealed
characteristics
satisfactory
good
performance.
Sample
977
exhibited
the
highest
performance,
comparison
original
(sample
810)
demonstrated
significant
improvements
critical
areas,
emphasizing
efficacy
refined
composition.
The
study
identified
directly
addresses
received
team’s
surrogate.
underscores
delicate
balance
between
biofidelity
practicality
simulation.
need
ongoing
refinement
evident
optimize
training
experiences
learners.
Язык: Английский
Pilot Evaluation of Silicone Surrogates for Oral Mucosa Simulation in Craniofacial Surgical Training
Biomimetics,
Год журнала:
2024,
Номер
9(8), С. 464 - 464
Опубликована: Авг. 1, 2024
Surgical
simulators
are
crucial
in
early
craniofacial
and
plastic
surgical
training,
necessitating
synthetic
materials
that
accurately
replicate
tissue
properties.
Recent
critiques
of
our
lab’s
currently
deployed
silicone
surrogate
have
highlighted
numerous
areas
for
improvement.
To
further
refine
models,
group’s
objective
is
to
find
a
composition
closest
fidelity
native
oral
mucosa
during
rehearsal
by
expert
surgeons.
Fifteen
platinum
silicone-based
samples
were
constructed
with
variable
hardness
slacker
percentages.
These
underwent
evaluation
tactile
sensation,
hardness,
needle
puncture,
cut
resistance,
suture
retention,
defect
repair,
tensile
elasticity.
Expert
surgeon
evaluators
provided
focused
qualitative
feedback
on
selected
top-performing
assessment
statistical
comparisons.
An
revealed
characteristics
satisfactory
exhibited
good
performance.
Sample
977
the
highest
performance,
comparison
original
(sample
810)
demonstrated
significant
improvements
critical
areas,
emphasizing
efficacy
refined
composition.
The
study
identified
directly
addresses
received
team’s
surrogate.
underscores
delicate
balance
between
biofidelity
practicality
simulation.
need
ongoing
refinement
evident
optimize
training
experiences
learners.
Язык: Английский
The Role of Cartilage Tissue Engineering in Osteoarthritis Treatment: The Bench to Bedside Translation
Journal of Polymer Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 31, 2024
ABSTRACT
Cartilage
tissue
engineering
holds
huge
promise
for
joint
defects
and
osteoarthritis
(OA)
conditions
which
otherwise
have
limited
treatment
options
due
to
cartilage's
inherent
inability
self‐repair.
Chemical
cues
play
a
pivotal
role
in
regulating
chondrocyte
behavior
matrix
synthesis.
Strategies
utilizing
growth
factors,
small
molecules,
biomaterial‐based
delivery
systems
aim
modulate
chondrogenic
differentiation,
proliferation,
deposition,
while
recent
insights
emphasize
the
significance
of
mimicking
native
gradients
optimal
regeneration
outcomes.
Mechanical
stimuli
profoundly
influence
phenotype
function,
necessitating
precise
control
mechanical
microenvironment
strategies.
Advances
biomaterial
design,
scaffold
fabrication,
bioreactor
facilitate
tailored
modulation
cues,
including
substrate
stiffness,
topography,
dynamic
loading
regimes.
This
review
showcases
latest
advancements
both
chemical
enhance
regeneration.
Furthermore,
exploring
synergistic
effects
combining
underscores
importance
multifaceted
approaches
promoting
robust
The
also
addresses
challenges
future
directions
field,
such
as
achieving
spatially
organized
architecture
integrating
patient‐specific
propel
cartilage
engineering.
We
conducted
comprehensive
enlistment
clinical
trials
engineering‐based
marketed
products
OA
therapy.
Язык: Английский
On-demand beamforming and wide dynamic power range for WPT and EH applications
International Journal of Microwave and Wireless Technologies,
Год журнала:
2024,
Номер
16(6), С. 903 - 918
Опубликована: Июль 1, 2024
Abstract
This
work
delves
into
advancements
in
wireless
power
transfer
(WPT)
and
radiofrequency
(RF)
energy
harvesting
(EH),
focusing
on
on-demand
beamforming
wide-dynamic
range
technologies.
These
innovations
promise
significant
improvements
efficiency
adaptability
for
systems.
For
transmitting
RF
power,
enhances
delivery
precision
by
accurately
targeting
specific
devices,
minimizing
waste,
maximizing
received
power.
technology
is
particularly
useful
dynamic
environments
with
constantly
changing
device
positions,
ensuring
stable
levels
effective
real-time
transfer,
such
as
mobile
charging.
receiving
implementation
allows
EH
WPT
systems
to
adjust
output
across
a
broad
spectrum,
optimizing
use
extending
lifespan.
capability
supports
scalability,
accommodating
devices
varied
needs,
also
enabling
new
applications
consumer
electronics,
healthcare,
smart
homes,
cities,
enhancing
management
infrastructures.
Additionally,
this
study
explores
three-dimensional
(3D)-printable
antennas
circuitries
battery-free
applications.
The
versatility
of
3D
printing
the
creation
complex,
efficient,
customizable
components,
fostering
innovative
solutions.
Integrating
technologies
improved
efficiencies,
reduced
losses,
sustainable,
cost-effective
Язык: Английский