Tetrahedral Framework Nucleic Acid-Based Delivery System for miRNA-124 and Stroke-Homing Peptide: Targeted Therapy for Acute Ischemic Stroke DOI
Guannan Du,

Yangxue Yao,

Wen Chen

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Фев. 12, 2025

Acute ischemic stroke (AIS) is associated with a high mortality rate and poor prognosis, lack of effective therapeutic drugs for post-thrombolytic treatment. MicroRNA-based gene therapy promising approach treating AIS, but its clinical application has been limited due to challenges, such as targeting efficiency, unsatisfactory stability, inadequate cellular uptake. In this study, we successfully developed microRNA-targeted delivery system based on the tetrahedral framework nucleic acid (tFNA). This nanodelivery system, guided by stroke-homing peptides, effectively targeted delivered miRNA124 hemisphere. With assistance tFNA, efficiently entered cells exerted effects. Additionally, it promoted transformation microglia from pro-inflammatory M1 phenotype anti-inflammatory M2 phenotype, reducing neuronal apoptosis and, ultimately, decreasing infarct size rate. These findings present strategy treatment AIS.

Язык: Английский

Tetrahedral Framework Nucleic Acid-Based Delivery System for miRNA-124 and Stroke-Homing Peptide: Targeted Therapy for Acute Ischemic Stroke DOI
Guannan Du,

Yangxue Yao,

Wen Chen

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Фев. 12, 2025

Acute ischemic stroke (AIS) is associated with a high mortality rate and poor prognosis, lack of effective therapeutic drugs for post-thrombolytic treatment. MicroRNA-based gene therapy promising approach treating AIS, but its clinical application has been limited due to challenges, such as targeting efficiency, unsatisfactory stability, inadequate cellular uptake. In this study, we successfully developed microRNA-targeted delivery system based on the tetrahedral framework nucleic acid (tFNA). This nanodelivery system, guided by stroke-homing peptides, effectively targeted delivered miRNA124 hemisphere. With assistance tFNA, efficiently entered cells exerted effects. Additionally, it promoted transformation microglia from pro-inflammatory M1 phenotype anti-inflammatory M2 phenotype, reducing neuronal apoptosis and, ultimately, decreasing infarct size rate. These findings present strategy treatment AIS.

Язык: Английский

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