Expert Review of Molecular Diagnostics, Год журнала: 2024, Номер unknown, С. 1 - 14
Опубликована: Окт. 10, 2024
Introduction Nonalcoholic fatty liver disease (NAFLD) is a common metabolism-related worldwide. Although studies have shown that some medications may be effective for treating NAFLD, they do not satisfy the medical requirements, and lifestyle changes are most basic strategy. Thus, early detection of NAFLD timely interventions highly important.
Язык: Английский
Pharmaceuticals, Год журнала: 2024, Номер 17(10), С. 1354 - 1354
Опубликована: Окт. 10, 2024
Metabolic-Associated Fatty Liver Disease (MAFLD) is a clinical-pathological scenario that occurs due to the accumulation of triglycerides in hepatocytes which considered significant cause liver conditions and contributes an increased risk death worldwide. Even though possible causes MAFLD can involve interaction genetics, hormones, nutrition, lifestyle (diet sedentary lifestyle) most influential factor developing this condition. Polyphenols comprise many natural chemical compounds be helpful managing metabolic diseases. Therefore, aim review was investigate impact oxidative stress, inflammation, mitochondrial dysfunction, role polyphenols MAFLD. Some reverse part damage related or among them are anthocyanin, baicalin, catechin, curcumin, chlorogenic acid, didymin, epigallocatechin-3-gallate, luteolin, mangiferin, puerarin, punicalagin, resveratrol, silymarin. These have actions reducing plasma enzymes, body mass index, waist circumference, adipose visceral indices, lipids, glycated hemoglobin, insulin resistance, HOMA index. They also reduce nuclear factor-KB (NF-KB), interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), blood pressure, fat content, steatosis fibrosis. On other hand, they improve HDL-c, adiponectin levels, fibrogenesis markers. results show promising prevention treatment
Язык: Английский
Процитировано
8
Annals of Hepatology, Год журнала: 2025, Номер unknown, С. 101900 - 101900
Опубликована: Март 1, 2025
Aminotransferases, particularly alanine aminotransferase (ALT), are commonly used in the detection, diagnosis, and management of chronic liver diseases. ALT, a sensitive cost-effective marker injury, remains pivotal predicting clinical outcomes guiding interventions several diseases including metabolic dysfunction-associated steatotic disease, viral hepatitis. This study aims to explore evolving role ALT as biomarker. A comprehensive review evidence was conducted, focusing on studies evaluating thresholds, diagnostic accuracy, integration with non-invasive assessment tools. Special emphasis given novel approaches, artificial intelligence-driven algorithms. Expert opinions from hepatology care perspectives were considered assess practical implications refining ALT-based strategies. levels influenced by diverse factors such age, gender, risks, challenging use specific thresholds biomarker disease prognosis. Emerging suggests redefining ranges enhance sensitivity accuracy detecting abnormalities. The advanced tools, intelligence, patient assessments can optimize early detection thus reducing underdiagnosis, asymptomatic or vulnerable populations. work highlights urgency tailor approaches primary specialized care, ensuring timely targeted intervention effectively address global burden
Язык: Английский
Процитировано
0
Diabetes/Metabolism Research and Reviews, Год журнала: 2024, Номер 40(8)
Опубликована: Ноя. 1, 2024
ABSTRACT Aims This study investigated the association of postprandial plasma glucose (PPG) with cancer mortality using a general cohort US adults. Materials and Methods included 14,860 adults who attended third National Health Nutrition Examination Survey from 1988 to 1994, being followed up until December 31, 2019. The explanatory variable was level glucose, including PPG fasting time 0–3.9 h (PPG 0–3.9h ) 4–7.9 4–7.9h ), ≥8 (PG at 2 after oral tolerance test 2hOGTT ). Plasma glucose‐associated risk assessed Cox proportional hazard models. Results A 1‐natural‐log‐unit increase in associated higher multivariate‐adjusted for [hazard ratio (HR), 3.24; 95% confidence interval (CI), 1.50–7.00]. However, , PG haemoglobin 1c insulin were not significantly mortality. positive remained those without prior diagnosis cancer. Conclusions High is Lowering may reduce
Язык: Английский
Процитировано
1
World Journal of Gastroenterology, Год журнала: 2024, Номер 30(34), С. 3875 - 3882
Опубликована: Сен. 8, 2024
As the Editor-in-Chief of
Язык: Английский
Процитировано
0
Expert Review of Molecular Diagnostics, Год журнала: 2024, Номер unknown, С. 1 - 14
Опубликована: Окт. 10, 2024
Introduction Nonalcoholic fatty liver disease (NAFLD) is a common metabolism-related worldwide. Although studies have shown that some medications may be effective for treating NAFLD, they do not satisfy the medical requirements, and lifestyle changes are most basic strategy. Thus, early detection of NAFLD timely interventions highly important.
Язык: Английский
Процитировано
0