Fusobacterium nucleatum confirmed in gastric biopsies of patients without Helicobacter pylori
BMC Research Notes,
Год журнала:
2025,
Номер
18(1)
Опубликована: Март 11, 2025
Putative
associations
between
certain
bacteria
and
gastric
cancer
have
been
described
previously;
however,
the
mechanisms
underlying
such
are
not
thoroughly
understood.
We
aimed
to
confirm
presence
of
Fusobacterium
nucleatum
in
biopsy
samples
patients
with
gastroduodenal
diseases,
including
cancer,
concomitant
or
without
Helicobacter
pylori
infection.
Three
hundred
disorders,
gastritis,
duodenal
ulcer,
were
included.
One
eighty
(60%)
negative
120
(40%)
positive
for
H.
pylori.
Associations
age,
gender,
other
demographics
statistically
insignificant
(p
>
0.05).
The
prevalence
F.
infection
was
determined
two
patient
categories:
215
(72%)
nucleatum;
these
cases,
95
showed
evidence
of,
lacked,
Gastric
biopsies
obtained
from
but
revealed
a
significant
Язык: Английский
Streptococcus anginosus: the potential role in the progression of gastric cancer
Journal of Cancer Research and Clinical Oncology,
Год журнала:
2025,
Номер
151(4)
Опубликована: Апрель 19, 2025
Gastric
cancer
(GC)
is
among
the
most
common
and
aggressive
malignancies
worldwide,
characterized
by
a
poor
prognosis.
Research
on
its
pathogenesis
progression
continues
to
evolve.
Streptococcus
anginosus
(S.
anginosus,
SA)
Gram-positive
coccus
commonly
found
in
oral
cavity
upper
respiratory
tract,
serving
as
commensal
bacterium
oral,
gastrointestinal,
genitourinary
tracts.
It
frequently
associated
with
abscess
formation
various
organs
tissues,
well
other
purulent
infections.
In
recent
years,
S.
has
gained
increasing
attention
for
role
GC
progression,
potentially
leading
chronic
gastric
inflammation
precancerous
lesions,
ultimately
promoting
development
of
GC.
Emerging
evidence
indicates
strong
association
between
malignant
unfavorable
prognosis
This
review
summarizes
underlying
mechanisms
proposes
that
plays
pivotal
initiation
underscoring
potential
therapeutic
significance.
Язык: Английский