Handbook of Religion and Health

Oxford University Press eBooks, Год журнала: 2023, Номер unknown

Опубликована: Ноя. 23, 2023

Abstract The 2001 (first) edition of this Handbook was a comprehensive review history, research, and discussions on religion health through the year 2000. Appendix listed 1,200 separate quantitative studies each rated in quality 0–10 scale, followed by about 2,000 references an extensive index for rapid topic identification. 2012 (second) systematically updated research from 2000 to 2010, with number then reaching thousands. This 2023 (third) is most scientifically rigorous date, covering best published 2021 emphasis prospective randomized controlled trials. Beginning Foreword Dr. Howard K. Koh, former US Assistant Secretary Health Department Human Services, nearly 600,000-word volume examines almost every aspect health, reviewing past more recent relationship between outcomes. Furthermore, all its 34 chapters conclude clinical community applications, making text relevant both healthcare professionals (physicians, nurses, social workers, rehabilitation therapists, counselors, psychologists, sociologists, etc.) clergy (community clergy, chaplains, pastoral etc.). book’s focuses studies, describing study single line, allowing researchers quickly locate existing research. It should not be surprising that two decades has been cited health.

Язык: Английский

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Theranostic Fluorescent Probes

Chemical Reviews, Год журнала: 2024, Номер 124(5), С. 2699 - 2804

Опубликована: Фев. 29, 2024

The ability to gain spatiotemporal information, and in some cases achieve control, the context of drug delivery makes theranostic fluorescent probes an attractive intensely investigated research topic. This interest is reflected steep rise publications on topic that have appeared over past decade. Theranostic probes, their various incarnations, generally comprise a fluorophore linked masked drug, which released as result certain stimuli, with both intrinsic extrinsic stimuli being reported. release then signaled by emergence signal. Importantly, use appropriate fluorophores has enabled not only this emerging fluorescence marker for but also provided modalities useful photodynamic, photothermal, sonodynamic therapeutic applications. In review we highlight recent work particular focus are activated tumor microenvironments. We summarize efforts develop other applications, such neurodegenerative diseases antibacterials. celebrates diversity designs reported date, from discrete small-molecule systems nanomaterials. Our aim provide insights into potential clinical impact still-emerging direction.

Язык: Английский

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Targeting Human Glucocorticoid Receptors in Fear Learning: A Multiscale Integrated Approach to Study Functional Connectivity

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(2), С. 864 - 864

Опубликована: Янв. 10, 2024

Fear extinction is a phenomenon that involves gradual reduction in conditioned fear responses through repeated exposure to fear-inducing cues. Functional brain connectivity assessments, such as functional magnetic resonance imaging (fMRI), provide valuable insights into how regions communicate during these processes. Stress, ubiquitous aspect of life, influences learning and by changing the activity amygdala, prefrontal cortex, hippocampus, leading enhanced and/or impaired extinction. Glucocorticoid receptors (GRs) are key stress response show dual function regulation: while they enhance consolidation memories, also facilitate Accordingly, GR dysregulation associated with anxiety mood disorders. Recent advancements cognitive neuroscience underscore need for comprehensive understanding integrates perspectives from molecular, cellular, systems levels. In particular, neuropharmacology provides neurotransmitter receptor systems, aiding investigation mechanisms underlying regulation potential therapeutic targets. A notable player this context cortisol, hormone, which significantly both memory reconsolidation Gaining thorough intricate interactions has implications terms addressing psychiatric disorders related stress. This review sheds light on complex between processes, emotions, their neural bases. endeavor, our aim reshape comprehension fear, stress, emotional well-being, ultimately development interventions.

Язык: Английский

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Neurobiology and systems biology of stress resilience

Physiological Reviews, Год журнала: 2024, Номер 104(3), С. 1205 - 1263

Опубликована: Март 14, 2024

Stress resilience is the phenomenon that some people maintain their mental health despite exposure to adversity or show only temporary impairments followed by quick recovery. Resilience research attempts unravel factors and mechanisms make possible harness its insights for development of preventative interventions in individuals at risk acquiring stress-related dysfunctions. Biological has been lagging behind psychological social sciences but seen a massive surge recent years. At same time, progress this field hampered methodological challenges related finding suitable operationalizations study designs, replicating findings, modeling animals. We embed review behavioral, neuroimaging, neurobiological, systems biological findings adults critical methods discussion. find preliminary evidence hippocampus-based pattern separation prefrontal-based cognitive control functions protect against pathological fears aftermath singular, event-type stressors [as found fear-related disorders, including simpler forms posttraumatic stress disorder (PTSD)] facilitating perception safety. Reward system-based pursuit savoring positive reinforcers appear more generalized dysfunctions anxious-depressive spectrum resulting from severe longer-lasting (as depression, comorbid anxiety, PTSD). Links between preserved functioning these neural under neuroplasticity, immunoregulation, gut microbiome composition, integrity barrier blood-brain are beginning emerge. On basis, avenues pointed out.

Язык: Английский

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Post-traumatic stress disorder (PTSD) as a systemic disorder: Pathways to cardiovascular disease.

Health Psychology, Год журнала: 2021, Номер 41(10), С. 651 - 662

Опубликована: Ноя. 22, 2021

Evidence indicates that post-traumatic stress disorder (PTSD) is a significant risk factor for the development and progression of cardiovascular disease (CVD). Most explanations PTSD-CVD associations conceptualize PTSD as stress-related mental health elicits physiological, behavioral, psychological responses are causal factors in disorders. This article reviews evidence broader physical consequences PTSD, presents conceptual model based on research suggesting systemic disorder. Specifically, findings indicate diagnostic criteria just "tip iceberg" with elements factors. These physiological behavioral therefore should not be regarded accompanying but unrelated diseases or comorbidities, inherent components directly impact CVD. The approach has implications conceptualization factor, needed CVD, clinical efforts to reduce PTSD-associated risk. It suggested treatments aim need address both its associated Further test applicability perspective. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Язык: Английский

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Post-traumatic Stress Disorder: Focus on Neuroinflammation

Molecular Neurobiology, Год журнала: 2023, Номер 60(7), С. 3963 - 3978

Опубликована: Апрель 1, 2023

Язык: Английский

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Inflammation as a Neurobiological Mechanism of Cognitive Impairment in Psychological Stress

Journal of Integrative Neuroscience, Год журнала: 2024, Номер 23(5)

Опубликована: Май 15, 2024

The feeling of emotional tension, restlessness, pressure, and inability to relax is referred as psychological stress. Although it unclear how stress affects neurobiological processes, several factors are thought be involved, including central peripheral neuroinflammation, structural degeneration in the prefrontal cortex hippocampus, alterations fear neurocircuitry, neuroplasticity. Aside from data relating cognitive impairment chronic low-grade inflammatory stress, there growing evidence linking mental oxidative systemic inflammation development disorders. After acute illnesses, insomnia, depression, anxiety, posttraumatic disorder, were reported. Cognitive exacerbated by processes. There uncertainty about potential mechanisms causing these symptoms, although they likely complex, with playing a significant role. Therefore, this review aims investigate role stress-induced impairment. Depicting critical for understanding treating such exposure anxiety

Язык: Английский

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The effects of COVID-19 continuous traumatic stressors on mental health and cognitive functioning: A case example from Turkey

Current Psychology, Год журнала: 2021, Номер 41(10), С. 7371 - 7382

Опубликована: Апрель 21, 2021

There is a need to accurately assess the specific impacts of various traumatic stressors caused by COVID-19 on mental health. The goal was evaluate impact different types (infection fears, lockdown, and economic stressors) health cognitive functioning. We used sample 262 Turkish adults. administered an online questionnaire that included measures stressors, PTSD, depression, anxiety, executive function deficits, cumulative traumas (CST). analyses correlations, hierarchical regression, path analysis, PROCESS mediation analysis. All their load predicted deficits after controlling for previous infection. lockdown's were strongest predictors, compared fears stressors. Path analysis results indicated had direct effects working memory indirect inhibition deficits. Anxiety, mediated its PTSD. have conceptual clinical implications. continuous posttraumatic stress syndrome includes comorbid does not fit within current trauma frameworks. paradigm shift in frameworks account global innovations intervention help victims.

Язык: Английский

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PTSD, Immune System, and Inflammation

Advances in experimental medicine and biology, Год журнала: 2023, Номер unknown, С. 225 - 262

Опубликована: Янв. 1, 2023

Язык: Английский

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The Functional Connectome and Long-Term Symptom Presentation Associated With Mild TBI and Blast Exposure in Combat Veterans

Journal of Neurotrauma, Год журнала: 2024, Номер unknown

Опубликована: Авг. 16, 2024

Mild traumatic brain injury (TBI) sustained in a deployment environment (deployment TBI) can be associated with increased severity of long-term symptom presentation, despite the general expectation full recovery from single mild TBI. The heterogeneity effects TBI on difficult for case-control design to capture. functional connectome is an approach robust that allows global measurement using common set outcomes. present study evaluates how differences relate remote presentation following combat and determines if TBI, blast exposure, or post-traumatic stress disorder (PTSD) are these neurological differences. Participants included 181 Iraq Afghanistan combat-exposed Veterans, approximately 9.4 years since deployment. Structured clinical interviews provided diagnoses characterizations PTSD. Self-report measures characterization symptoms (psychiatric, behavioral health, quality life). Resting-state magnetoencephalography was used characterize individually each participant. Linear regression identified factors contributing including relevant covariates, metrics, exposure PTSD, conditional relationships. Results unique contributions aspects presentation. Furthermore, several relationships were identified, demonstrating related outcomes presence only deployment-related (including blast-related primary exposure). No PTSD; however, main effect PTSD significant all models. These results demonstrate captures function highlighting influences through pathway. findings changes over decade past event, providing clear demonstration brain-based mechanism influence.

Язык: Английский

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