International Journal of Pharmaceutics, Год журнала: 2023, Номер 651, С. 123723 - 123723
Опубликована: Дек. 17, 2023
Язык: Английский
Bulletin of the Chemical Society of Japan, Год журнала: 2023, Номер 97(1)
Опубликована: Дек. 1, 2023
Abstract Nanotechnology has revealed the science of nanoscale. The global challenge that will follow is to build functional materials with knowledge nanoscale phenomena. This task carried out by nanoarchitectonics as a postnanotechnology concept. goal material systems architecting atoms, molecules, and nanomaterials building blocks. Fundamentally, all are made atoms molecules. Therefore, nanoarchitectonics, which architects from can be universal way create materials. It may said method for everything in science. From basic units, living cells, complex systems, components nanoarchitectonics. paper presents recent examples research at various size levels, atomic cellular level, specifically, (i) atomistic (ii) molecular (iii) supramolecular (iv) inorganic (v) biomolecular (vi) cell-mimic (vii) cell-based possibility science, an integrative then explored.
Язык: Английский
Процитировано
119
Materials, Год журнала: 2025, Номер 18(3), С. 654 - 654
Опубликована: Фев. 1, 2025
The development of functional materials and the use nanotechnology are ongoing projects. These fields closely linked, but there is a need to combine them more actively. Nanoarchitectonics, concept that comes after nanotechnology, ready do this. Among related research efforts, into creating through formation thin layers on surfaces, molecular membranes, multilayer structures these have lot implications. Layered especially important as key part nanoarchitectonics. diversity components used in layer-by-layer (LbL) assemblies notable feature. Examples LbL introduced this review article include quantum dots, nanoparticles, nanocrystals, nanowires, nanotubes, g-C3N4, graphene oxide, MXene, nanosheets, zeolites, nanoporous materials, sol–gel layered double hydroxides, metal–organic frameworks, covalent organic conducting polymers, dyes, DNAs, polysaccharides, nanocelluloses, peptides, proteins, lipid bilayers, photosystems, viruses, living cells, tissues. examples assembly show how useful versatile it is. Finally, will consider future challenges
Язык: Английский
Процитировано
7
Advances in Colloid and Interface Science, Год журнала: 2025, Номер 339, С. 103420 - 103420
Опубликована: Фев. 3, 2025
Язык: Английский
Процитировано
5
ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(34), С. 40228 - 40240
Опубликована: Авг. 16, 2023
Psoriasis is a chronic inflammatory skin disease that difficult to treat. Quercetin (QT) dietary flavonoid known for its anti-inflammatory effects and safe use in humans. However, the topical application of quercetin psoriasis treatment presents significant challenge due poor water solubility low stability semisolid preparations, where it tends recrystallize. This work novel liposome-in-gel formulation quercetin-based psoriasis. The quercetin-loading liposomes are stabilized by hydroxypropyl-β-cyclodextrin (HPCD), which interacts with phospholipids via hydrogen bonding form layer an HPCD coating on liposome interface, thus resulting improved stability. Various analytical techniques, such as FTIR spectroscopy, Raman TEM, were used characterize molecular coordination patterns between cyclodextrin liposomes. results demonstrated assisted interfacing matrix lipids keratins stratum corneum, thereby enhancing permeability promoting drug penetration retention skin. vivo showed QT HPCD-liposome-in-gel efficacy psoriatic plaque compared free QT. It alleviated symptoms thickening downregulated proinflammatory cytokines, including TNF-α, IL-17A, IL-1β. suggested HPCD-coordinated system could be stable carrier therapy good potential treatment.
Язык: Английский
Процитировано
25
Nanoscale, Год журнала: 2024, Номер 16(28), С. 13230 - 13246
Опубликована: Янв. 1, 2024
Nanoarchitectonics may be highly compatible with applications in biological systems. Construction strategies and functions of bio-gel nanoarchitectonics medical tissue engineering are discussed.
Язык: Английский
Процитировано
12
Materials, Год журнала: 2024, Номер 17(1), С. 271 - 271
Опубликована: Янв. 4, 2024
The next step in nanotechnology is to establish a methodology assemble new functional materials based on the knowledge of nanotechnology. This task undertaken by nanoarchitectonics. In nanoarchitectonics, we architect material systems from nanounits such as atoms, molecules, and nanomaterials. terms hierarchy structure harmonization function, created nanoarchitectonics has similar characteristics organization biosystems. Looking at actual biofunctional systems, dynamic properties interfacial environments are key. other words, interfaces important for production bio-like highly systems. this review paper, will be discussed, looking recent typical examples. particular, basic topics “molecular manipulation, arrangement, assembly” “material production” discussed first two sections. Then, following section, “fullerene assembly: zero-dimensional unit advanced materials”, discuss how various structures can very nanounit, fullerene. above examples demonstrate versatile possibilities architectonics interfaces. last these tendencies summarized, future directions discussed.
Язык: Английский
Процитировано
10
Carbohydrate Polymers, Год журнала: 2023, Номер 323, С. 121348 - 121348
Опубликована: Авг. 31, 2023
Язык: Английский
Процитировано
23
Journal of Inorganic and Organometallic Polymers and Materials, Год журнала: 2024, Номер 34(7), С. 2926 - 2947
Опубликована: Апрель 16, 2024
Abstract The characteristic feature of a biofunctional system is that components with various functions work together. These multi-components are not simply mixed together, but rationally arranged. fundamental technologies to do this in an artificial include the synthetic chemistry substances make component unit, science and techniques for assembling them, technology analyzing their nanoostructures. A new concept, nanoarchitectonics, can play role. Nanoarchitectonics post-nanotechnology concept involves building functional materials reflect nanostructures. In particular, approach combining multiple types create composite area where nanoarchitectonics be powerful tool. This review summarizes such examples related studies. presented areas catalyst & photocatalyst, energy, sensing environment, bio medical, other applications illustrate potential wide range applications. order show stages development, only state-of-the-art, also those successful developments existing research. Finally, summary brief discussion future challenges will given. applicable all aims establish ultimate methodology science.
Язык: Английский
Процитировано
5
Science and Technology of Advanced Materials, Год журнала: 2023, Номер 24(1)
Опубликована: Авг. 24, 2023
This review comprehensively covers synthetic catalysts for the hydrolysis of biorelevant phosphates and pyrophosphates, which bridge between nanoarchitectonics biology to construct their interdisciplinary hybrids. In early 1980s, remarkable catalytic activity Ce4+ ion phosphate was found. More recently, this finding has been extended Ce-based solid (CeO2 metal-organic frameworks (MOFs)), are directly compatible with nanoarchitectonics. Monoesters triesters phosphates, as well were effectively cleaved by these catalysts. With use either CeO2 nanoparticles or elegantly designed MOF, highly stable phosphodiester linkages also hydrolyzed. On surfaces all catalysts, Ce3+ coexist cooperate catalysis. The activates substrates a strong acid, whereas provides metal-bound hydroxide an eminent nucleophile. Applications practical purposes discussed.
Язык: Английский
Процитировано
10
ACS Applied Nano Materials, Год журнала: 2024, Номер 7(10), С. 11432 - 11444
Опубликована: Май 8, 2024
Triple-negative breast cancer (TNBC) is an aggressive subtype with high immunogenicity. In this study, we developed a peptide-modified cyclodextrin-based nanosystem for co-delivery of celastrol and siPD-L1, named H4R6RGD-carboxymethyl-β-cyclodextrin@celastrol/siPD-L1 nanoparticles (H–C@C/siPD-L1 NPs). The cyclodextrin derivative could simultaneously utilize its cavity positively charged chain to deliver siPD-L1 (cela) through hydrophobic electrostatic interactions. H–C@C/siPD-L1 NPs exhibited excellent stability dispersibility. Characterization revealed that the spherical morphology, displaying smooth surfaces average diameter approximately 200 nm. demonstrated enhanced cellular uptake efficient lysosomal escape, thereby improving drug utilization while minimizing side effects on normal tissues. Furthermore, facilitated delivery effectively reducing expression PD-L1. This, in turn, promoted tumor apoptosis augmented antitumor effect endoplasmic reticulum (ER) stress-related apoptotic pathway. Notably, multifunctional nanodrug system, designed combination chemotherapy gene therapy, not only potent but also improved immunosuppressive microenvironment tumor. targeted cela holds significant potential advancing application chemotherapeutic genic nanomedicine treatment TNBC. materials would have good prospects field clinical delivery.
Язык: Английский
Процитировано
4