Journal of Controlled Release, Год журнала: 2025, Номер 381, С. 113595 - 113595
Опубликована: Март 6, 2025
In receptor-mediated transcytosis (RMT) of large therapeutics across the blood-brain barrier (BBB), construct - a macromolecule or larger carrier with therapeutic payload binds protein on brain capillary endothelial cells (BCEC), internalization and release into parenchyma. The construct's into, trafficking from, but also possible entrapment within BCEC are affected by its engineered properties whose optimization has helped derive insights transport mechanisms at BCEC. Furthermore, advances in multi-omics, as well large-scale screening directed evolution campaigns have identify new targets for RMT this perspective, I raise reflect some fundamental questions one can arrive comparing BBB-targeted constructs different target proteins. These concern underlying, transcytosis-promoting factors that constructs' appears to converge on, precise role proteins RMT, through which these may mediate trafficking, tentative criteria selection Based considerations propose several scenarios strategies interfere more efficient internalization, endosomal network toward abluminal membrane, from BCEC, both smaller macromolecules carriers.
Язык: Английский