The Groebke–Blackburn–Bienaymé (GBB) Reaction: A Powerful Tool for Generating Diverse Heterocyclic Scaffold Libraries in Anticancer Drug Discovery

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер 291, С. 117629 - 117629

Опубликована: Апрель 12, 2025

Язык: Английский

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Furans derived from lignocellulosic biomass as renewable substrates in multicomponent reactions

Sustainable Chemistry and Pharmacy, Год журнала: 2025, Номер 44, С. 101948 - 101948

Опубликована: Фев. 11, 2025

Язык: Английский

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Identification of a New Promising BAG3 Modulator Featuring the Imidazopyridine Scaffold

Molecules, Год журнала: 2024, Номер 29(21), С. 5051 - 5051

Опубликована: Окт. 25, 2024

The antiapoptotic BAG3 protein plays a crucial role in cellular proteostasis and it is involved several signalling pathways governing cell proliferation survival. Owing to its multimodular structure, possesses an extensive interactome including the molecular chaperone HSP70 other specific partners, which make eminent factor pathologies, particularly cancer. Despite potential as therapeutic target, very few modulators have been disclosed so far. Here we describe identification of promising modulator able bind BAG domain featuring imidazopyridine scaffold obtained through application Groebke-Blackburn-Bienaymé chemical synthesis procedure. compound

Язык: Английский

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Comparative Study of the Catalytic Activity of Hypervalent Halogen(III) and Chalcogen(IV) Salts in the Imine–Isocyanide Coupling

Russian Journal of General Chemistry, Год журнала: 2024, Номер 94(10), С. 2632 - 2637

Опубликована: Окт. 1, 2024

Язык: Английский

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Multicomponent One-Pot Synthesis of Imidazo[1,2-a]pyridine Functionalized with Azides

Опубликована: Ноя. 14, 2024

Язык: Английский

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