Crystal Structure, Hirshfeld Surface Analysis, and Computational Insights into Phenoxyacetohydrazones: Hydrogen-Bonded Dimers and p-Stacking Interactions.
Journal of Molecular Structure,
Год журнала:
2025,
Номер
1333, С. 141752 - 141752
Опубликована: Фев. 16, 2025
Язык: Английский
Photo- and Electro-chemical Strategies for Indazole Synthesis
Tetrahedron Chem,
Год журнала:
2024,
Номер
unknown, С. 100116 - 100116
Опубликована: Дек. 1, 2024
The
indazole
core
is
prevalently
found
in
the
structures
of
bioactive
molecules,
demonstrating
promising
potential
medicinal
chemistry
and
drug
discovery,
which
therefore
has
attracted
sustained
attention
from
synthetic
community.
Over
recent
decades,
significant
progress
been
achieved
both
organic
photocatalysis
electrosynthesis,
offering
novel
approaches
for
efficient
sustainable
synthesis
various
functionalized
indazoles.
This
mini-review
highlights
emerging
methodological
advancements
photo-/electro-chemical
two
common
forms
indazole,
namely
1H-
2H-indazoles,
are
classified
by
specific
intramolecular
bond
formation
patterns:
(1)
C-C
formation,
(2)
C-N
(3)
N-N
formation.
reaction
conditions,
representative
scopes,
mechanistic
understandings
these
protocols
emphasized,
to
elucidate
advantages
limitations
current
strategies,
with
an
aim
inspire
future
innovations
that
may
address
challenges
modern
synthesis.Graphical
abstractTo
create
your
abstract,
type
over
instructions
template
box
below.
Fonts
or
abstract
dimensions
should
not
be
changed
altered.
Язык: Английский
A Focused Review on Oxidation of Hydrazones Using Hypervalent Iodine Reagents
ChemistrySelect,
Год журнала:
2024,
Номер
10(1)
Опубликована: Дек. 31, 2024
Abstract
Hydrazones
are
described
as
synthetic
equivalents
to
the
carbonyl
group
and
possess
high
synthon
value.
Herein,
we
compile
oxidative
transformation
of
hydrazones
using
ecologically
economically
benign
hypervalent
iodine
reagents
last
decade.
In
this
field,
development
C─H
functionalization
reactions
leading
formation
heterocycles
or
functionalized
is
a
major
advancement
in
recent
years.
The
properties
exploited
form
many
bioactive
(pyrazole,
pyrazoline,
pyridazine,
1,2,4‐triazole,
1,2,3‐tiazole,
1,3,4‐oxadiazole,
tetrazine,
tetrazole,
pyrrole)
through
intramolecular
intermolecular
C─N,
C─O,
N─N
coupling.
Functionalized
also
afforded
via
tandem
cascade
transfer/cyclization
reactions.
transfer
perfluoroalkyl,
sulfoximidoyl,
aryl,
halogen
groups
achieved
donors
oxidants
combination
with
other
group‐donating
agents.
Togni
reagent
preferred
choice
for
trifluoromethyl
donation,
without
metal
catalyst.
Moreover,
rearrangement
such
acyl
migration
diazotization
achieved.
Язык: Английский