The Role of Flow Chemistry on the Synthesis of Pyrazoles, Pyrazolines and Pyrazole-Fused Scaffolds DOI Creative Commons
Catarina M. Correia, Artur M. S. Silva, Vera L. M. Silva

и другие.

Molecules, Год журнала: 2025, Номер 30(7), С. 1582 - 1582

Опубликована: Апрель 2, 2025

Nitrogen-containing heterocycles are fundamental scaffolds in organic chemistry, particularly due to their prevalence pharmaceuticals, agrochemicals and materials science. Among them, five-membered rings, containing two nitrogen atoms adjacent positions—such as pyrazoles, pyrazolines indazoles—are especially significant versatile biological activities structural properties, which led the search for greener, faster more efficient methods synthesis. Conventional batch synthesis methods, while effective, often face challenges related reaction efficiency, scalability safety. Flow chemistry has emerged a powerful alternative, offering enhanced control over parameters, improved safety profiles opportunities scaling up processes efficiently. This review explores impact of flow on these pivotal heterocycles, highlighting its advantages conventional methods. Although indazoles have ring fused with benzene ring, they will also be considered this relevance.

Язык: Английский

The Role of Flow Chemistry on the Synthesis of Pyrazoles, Pyrazolines and Pyrazole-Fused Scaffolds DOI Creative Commons
Catarina M. Correia, Artur M. S. Silva, Vera L. M. Silva

и другие.

Molecules, Год журнала: 2025, Номер 30(7), С. 1582 - 1582

Опубликована: Апрель 2, 2025

Nitrogen-containing heterocycles are fundamental scaffolds in organic chemistry, particularly due to their prevalence pharmaceuticals, agrochemicals and materials science. Among them, five-membered rings, containing two nitrogen atoms adjacent positions—such as pyrazoles, pyrazolines indazoles—are especially significant versatile biological activities structural properties, which led the search for greener, faster more efficient methods synthesis. Conventional batch synthesis methods, while effective, often face challenges related reaction efficiency, scalability safety. Flow chemistry has emerged a powerful alternative, offering enhanced control over parameters, improved safety profiles opportunities scaling up processes efficiently. This review explores impact of flow on these pivotal heterocycles, highlighting its advantages conventional methods. Although indazoles have ring fused with benzene ring, they will also be considered this relevance.

Язык: Английский

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