Research advances in the study of traditional Chinese medicine formula granules on signaling pathway-mediated disease mechanisms DOI Creative Commons

Zhuoxu Gu,

Zhonghao Wang, Xianquan Zhang

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Июнь 3, 2025

As a modern dosage form of traditional Chinese medicine, Traditional Medicine Formula Granules (TCMFG) maximally retains active metabolites through standardized production processes, including dynamic countercurrent extraction and low-temperature concentration. This serves as critical material basis for elucidating its multi-target regulatory mechanisms. Recent studies have highlighted the significant potential TCMFG in treating complex diseases, such inflammation, tumors, metabolic disorders, fibrosis, orthopedic conditions like osteoarthritis osteoporosis, by modulating signaling pathways TLR4/NF-κB, MAPK, NLRP3 inflammasome, PI3K/Akt/mTOR, Wnt/β-catenin, TGF-β/Smads. For example, berberine alleviates acute lung injury inhibiting TLR4/NF-κB pathway, while tetramethylpyrazine derived from Ligusticum chuanxiong Hort granules mitigate joint destruction rheumatoid arthritis suppressing MAPK signaling. Curcumin analogs inhibit tumor reprogramming via PI3K/Akt pathway. Despite these advances, current research encounters challenges, single-component analysis, unclear synergistic mechanisms compound mixtures, insufficient clinical evidence translational applications. In future, integrating multi-omics technologies (e.g., metabolomics, spatial transcriptomics) will be crucial exploring supramolecular effects mixtures. Furthermore, large-scale trials are necessary to validate precision medicine. article systematically reviews progress pathway-mediated disease outlines future directions enhance application

Язык: Английский

Research advances in the study of traditional Chinese medicine formula granules on signaling pathway-mediated disease mechanisms DOI Creative Commons

Zhuoxu Gu,

Zhonghao Wang, Xianquan Zhang

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Июнь 3, 2025

As a modern dosage form of traditional Chinese medicine, Traditional Medicine Formula Granules (TCMFG) maximally retains active metabolites through standardized production processes, including dynamic countercurrent extraction and low-temperature concentration. This serves as critical material basis for elucidating its multi-target regulatory mechanisms. Recent studies have highlighted the significant potential TCMFG in treating complex diseases, such inflammation, tumors, metabolic disorders, fibrosis, orthopedic conditions like osteoarthritis osteoporosis, by modulating signaling pathways TLR4/NF-κB, MAPK, NLRP3 inflammasome, PI3K/Akt/mTOR, Wnt/β-catenin, TGF-β/Smads. For example, berberine alleviates acute lung injury inhibiting TLR4/NF-κB pathway, while tetramethylpyrazine derived from Ligusticum chuanxiong Hort granules mitigate joint destruction rheumatoid arthritis suppressing MAPK signaling. Curcumin analogs inhibit tumor reprogramming via PI3K/Akt pathway. Despite these advances, current research encounters challenges, single-component analysis, unclear synergistic mechanisms compound mixtures, insufficient clinical evidence translational applications. In future, integrating multi-omics technologies (e.g., metabolomics, spatial transcriptomics) will be crucial exploring supramolecular effects mixtures. Furthermore, large-scale trials are necessary to validate precision medicine. article systematically reviews progress pathway-mediated disease outlines future directions enhance application

Язык: Английский

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