European Heart Journal - Cardiovascular Pharmacotherapy,
Год журнала:
2023,
Номер
10(2), С. 118 - 127
Опубликована: Ноя. 28, 2023
Omega-3
fatty
acids
and
fenofibrates
have
shown
some
beneficial
cardiovascular
effects;
however,
their
efficacy
has
not
been
compared.
This
study
aimed
to
compare
the
effectiveness
of
currently
available
omega-3
fenofibrate
for
reducing
major
adverse
events
(MACE).
From
a
nationwide
population-based
cohort
in
South
Korea
(2008-2019),
individuals
with
metabolic
syndrome
(≥30
years)
who
received
statin
those
receiving
were
matched
by
propensity
score
(n
=
39
165
both
groups).
The
primary
outcome
was
MACE,
including
ischaemic
heart
disease
(IHD),
stroke
(IS),
death
from
causes.
risk
MACE
lower
[hazard
ratio
(HR),
0.79;
95%
confidence
interval
(CI),
0.74-0.83]
group
than
acid
group.
Fenofibrate
associated
incidence
IHD
(HR,
0.72;
CI,
0.67-0.77)
hospitalization
failure
0.90;
0.82-0.97),
but
IS
0.81-1.00)
nor
causes
1.07;
0.97-1.17).
effect
compared
prominent
patients
preexisting
atherosclerotic
doses
(≤2
g
per
day).
In
real-world
setting,
use
low-dose
when
added
statins
people
syndrome.
Healthcare,
Год журнала:
2023,
Номер
11(3), С. 433 - 433
Опубликована: Фев. 2, 2023
Obesity
is
a
growing
civilization
problem,
associated
with
number
of
negative
health
consequences
affecting
almost
all
tissues
and
organs.
Currently,
obesity
treatment
includes
lifestyle
modifications
(including
diet
exercise),
pharmacologic
therapies,
in
some
clinical
situations,
bariatric
surgery.
These
treatments
seem
to
be
the
most
effective
method
supporting
obesity.
However,
they
are
many
limitations
options,
both
for
practitioners
patients.
Often
comorbidities,
cost,
age
patient,
even
geographic
locations
may
influence
choices.
The
pharmacotherapy
fast-growing
market.
we
have
at
our
disposal
drugs
various
mechanisms
action
(directly
reducing
absorption
calories-orlistat,
acting
centrally-bupropion
naltrexone,
phentermine
topiramate,
or
multidirectional-liraglutide,
dulaglutide,
semaglutide).
whose
weight-reducing
effect
used
course
other
diseases
(e.g.,
glucose-sodium
cotransporter
inhibitors,
exenatide)
also
worth
mentioning.
focusing
on
novel
therapeutic
agents
improved
safety
efficacy
profiles.
trends
include
an
assessment
usefulness
properties
previously
diseases.
presented
paper
overview
studies
related
currently
those
undergoing
trials,
taking
into
account
individual
approach
patient.
Endocrinology and Metabolism,
Год журнала:
2024,
Номер
39(2), С. 353 - 363
Опубликована: Янв. 23, 2024
Background:
Polyunsaturated
fatty
acids
(PUFAs)
reportedly
have
protective
effects
on
pancreatic
β-cells;
however,
the
underlying
mechanisms
are
unknown.Methods:
To
investigate
cellular
mechanism
of
PUFA-induced
cell
protection,
mouse
insulinoma
6
(MIN6)
cells
were
cultured
with
palmitic
acid
(PA)
and/or
docosahexaenoic
(DHA),
and
alterations
in
signaling
apoptosis
examined.Results:
DHA
treatment
remarkably
repressed
caspase-3
cleavage
terminal
deoxynucleotidyl
transferase-mediated
UTP
nick
end
labeling
(TUNEL)-positive
red
dot
signals
PA-treated
MIN6
cells,
upregulation
autophagy,
an
increase
microtubule-
associated
protein
1-light
chain
3
(LC3)-II,
autophagy-related
5
(Atg5),
decreased
p62.
Upstream
factors
involved
autophagy
regulation
(Beclin-1,
unc51
like
activating
kinase
1
[ULK1],
phosphorylated
mammalian
target
rapamycin
[mTOR],
B)
also
altered
by
treatment.
specifically
induced
phosphorylation
S2448
mTOR;
S2481
decreased.
The
role
G
protein-coupled
receptor
120
(GPR120)
effect
was
demonstrated
using
a
GPR120
agonist
antagonist.
Additional
AH7614,
antagonist,
significantly
attenuated
DHA-induced
protection.
Taken
together,
activation
protection
against
PA-induced
mediated
GPR120/mTOR
axis.Conclusion:
These
findings
indicate
that
has
therapeutic
β-cells,
β-cell
may
be
new
research
potential
pharmacotherapeutic
implications
Lipids in Health and Disease,
Год журнала:
2024,
Номер
23(1)
Опубликована: Май 17, 2024
Lipid
accumulation
product
(LAP)
is
an
accessible
and
relatively
comprehensive
assessment
of
obesity
that
represents
both
anatomical
physiological
lipid
accumulation.
Obesity
psoriasis
are
potentially
related,
according
to
previous
research.
Investigating
the
relationship
between
adult
LAP
index
was
goal
this
study.
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Окт. 3, 2024
This
study
aims
to
investigate
the
relationship
between
lipid
accumulation
product
(LAP)
index
and
total
femur
bone
mineral
density
(BMD),
while
also
examining
mediating
role
of
poverty-income
ratio
(PIR).
Nutrients,
Год журнала:
2022,
Номер
14(19), С. 3911 - 3911
Опубликована: Сен. 21, 2022
Sarcopenic
obesity
is
a
new
category
of
and
specific
condition
sarcopenia.
This
study
aimed
to
find
the
relationship
basal
metabolic
rate
(BMR)
body
water
distribution
with
muscle
health
their
prospective
roles
in
screening
for
sarcopenic
The
role
nutrients
such
as
carbohydrates
was
further
detected.
A
total
402
elderly
subjects
were
recruited.
Body
composition
estimated
by
bioelectrical
impedance
analysis.
Sarcopenia
defined
Asian
Working
Group
2019.
cutoff
values
determined
receiver
operating
characteristic
curve.
Mediation
analyses
performed
using
SPSS
PROCESS.
Higher
BMR
BMR/body
surface
area
(BSA)
protective
factors
against
(OR
=
0.047,
p
0.004;
OR
0.035,
0.002)
sarcopenia
0.085,
0.001;
0.100,
0.003)
people.
Low
extracellular
(ECW)/intracellular
(ICW)
ECW/total
(TBW)
negatively
correlated
skeletal
index
(SMI).
intake
dietary
people
lowest,
but
obesity,
it
highest
(p
0.023).
results
moderated
mediation
model
showed
that
fully
mediated
positive
between
SMI,
which
more
obvious
population
an
abnormal
distribution.
or
BMR/BSA
had
potential
predicting
higher
risk
lower
ECW/ICW
ECW/TBW
may
benefit
health.
overconsumption
(especially
>
AMDR)
might
be
factor
obesity.
Moderate
carbohydrate
promote
SMI
regulating
elderly.
Molecular Medicine Reports,
Год журнала:
2025,
Номер
31(3)
Опубликована: Янв. 24, 2025
Asiasarum
root
and
rhizome
(Asarum)
is
commonly
used
as
a
diaphoretic.
Due
to
its
warm
pungent
characteristics
in
traditional
Chinese
Korean
medicine,
it
considered
having
the
potential
prevent
disease.
The
present
study
investigated
effects
of
Asarum
extract
on
symptoms
obesity
mice,
regulation
energy
metabolism
liver
skeletal
muscle
tissues.
In
addition,
identify
molecular
targets
signaling
pathways
involved
mechanism
action
obesity,
network
pharmacological
docking
analysis
was
performed.
vitro
studies
demonstrated
that
significantly
increased
expression
regulators
[sirtuin
1
(SIRT1),
peroxisome
proliferator‑activated
receptor
γ
coactivator
1‑α
(PGC1α),
nuclear
respiratory
factor
1,
AMP‑activated
protein
kinase
(AMPK)
glucose
transporter
type
4
(GLUT4)]
myogenic
regulatory
factors
(MyoD,
myogenin
myosin
heavy
chain)
C2C12
myotubes.
Furthermore,
vivo
could
reduce
increases
body
weight,
levels
blood
glucose,
insulin,
total
cholesterol,
triglycerides
low‑density
lipoprotein
cholesterol
sera
obese
mice.
also
improved
pathological
changes
pancreatic
tissues
ratio
brown
fat
mass
weight.
reversed
gastrocnemius
activated
SIRT1,
PGC1α
AMPK
These
findings
indicated
may
exert
anti‑obesity
effects,
such
weight
loss,
decreases
lipid
metabolite
levels,
inhibition
damage.
Using
analysis,
mechanisms
underlying
were
explored,
particularly
